Visible-Light-Mediated Deaminative Alkylation of Primary Amines with Silacarboxylic Acids via Isonitrile Formation

Organic Letters, Journal Year: 2025, Volume and Issue: 27(2), P. 583 - 587

Published: Jan. 7, 2025

The functionalization of the C–N bond amines is a straightforward strategy for construction complex scaffolds or late-stage pharmaceuticals. Herein, we describe photoredox-catalyzed deaminative alkylation primary amine-derived isonitriles that provides unnatural amino acid derivatives under mild conditions. use silacarboxylic acids as silyl radical precursors enables generation carbon-centered radicals allow Csp3–Csp3 bonds via Giese-type addition, avoiding undesired hydrodeamination product.

Language: Английский

Photocatalytic Denitrative Alkenylation of Nitroalkanes

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 25, 2024

Reductive radical generation has become a cornerstone of modern photoredox chemistry. However, the synthesis functionalized precursors remains tedious multistep process. In this study, we focus on potential nitro group as redox-active functional and present denitrative alkenylation nitroalkanes, facilitated by photoreductive alkyl radicals from nitroalkanes. By taking advantage facile α-functionalization successfully generate various radicals, which are subsequently used in reactions.

Language: Английский