Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

A photocatalysis-involved α-amino radical provides an appealing approach for rapid construction of complex amine architectures. Reported herein is organophotoredox catalytic to α-C-H alkylation and heteroarylation benzyl anilines, which enables the introduction valuable trifluoromethyl alcohol, chromanone, or pyridine motifs at α position amines. This protocol highlights metal-free, step atom economies broad substrate scopes (>80 examples). Control experiments electron paramagnetic resonance spectroscopy identified derived from C-H bond.

Language: Английский