Fabrication of atomically dispersed barium hydride catalysts for the synthesis of deuterated alkylarenes

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 21, 2025

Marvelous natures of alkali and alkaline earth metal hydrides in catalyzing chemical transformations are being discovered. However, the synthesis (sub)nanostructured hydrides, critically important to enhance their catalytic performances, is yet a very challenging task. Herein, we develop highly reactive heterogeneous catalyst comprising atomically dispersed barium on MgO support with an ultrahigh loading up 20 wt% via convenient preparation method involving liquid-ammonia impregnation followed by hydrogenation. The surface hydride species not only exhibits extraordinary reactivity toward H2 activation at room temperature, but also enables efficient hydrogen isotope exchange (HIE) both sp3 C–H sp2 bonds nonactivated alkylarenes using D2 as deuterium source under mild conditions. deuteration rate benzylic site two orders magnitude higher than that bulk BaH2. This study offers alternative synthetic route for manufacture deuterium-labeled compounds heterogenous transition metal-free beyond widely studied molecular complexe catalysts. Hydrogen essential remains demonstrates selective temperature hydride.

Language: Английский

Merging directed sp³ and nondirected sp² C–H functionalization for Pd-catalyzed polydeuteration of (hetero)arenes

Chemical Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A ligand-enabled strategy achieves deuteration with high deuterium enrichment through both directed sp 3 and nondirected 2 C–H deuteration.

Language: Английский