Visible-Light-Induced [2 + 2] Cyclization of Alkynes with Bromodifluoroacetylsilanes: Facile Access to gem-Difluorocyclobutenones DOI
Gang Zhou, Yongpeng Li, Ying Liu

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Herein, we report a simple and efficient method for the synthesis of gem-difluorocyclobutenones from alkynes bromodifluoroacetylsilanes, proceeding via formal cyclization with in situ generated difluoroketene under visible-light-induced conditions. The reaction conditions are mild exhibit broad substrate scope, including both aromatic aliphatic alkynes. Additionally, demonstrates good functional group tolerance, facile scalability, potential diverse downstream transformations. Mechanistic studies suggest that bromodifluoroacetylsilanes act as photochemical precursors to difluoroketene.

Language: Английский

Visible-Light-Induced [2 + 2] Cyclization of Alkynes with Bromodifluoroacetylsilanes: Facile Access to gem-Difluorocyclobutenones DOI
Gang Zhou, Yongpeng Li, Ying Liu

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Herein, we report a simple and efficient method for the synthesis of gem-difluorocyclobutenones from alkynes bromodifluoroacetylsilanes, proceeding via formal cyclization with in situ generated difluoroketene under visible-light-induced conditions. The reaction conditions are mild exhibit broad substrate scope, including both aromatic aliphatic alkynes. Additionally, demonstrates good functional group tolerance, facile scalability, potential diverse downstream transformations. Mechanistic studies suggest that bromodifluoroacetylsilanes act as photochemical precursors to difluoroketene.

Language: Английский

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