Journal of the American Chemical Society,
Journal Year:
2021,
Volume and Issue:
143(33), P. 12985 - 12991
Published: Aug. 10, 2021
Herein,
a
fast,
scalable,
and
transition-metal-free
borylation
of
alkyl
halides
(X
=
I,
Br,
Cl)
enabled
by
electroreduction
is
reported.
This
process
provides
an
efficient
practical
access
to
primary,
secondary,
tertiary
boronic
esters
at
high
current.
More
than
70
examples,
including
the
late-stage
natural
products
drug
derivatives,
are
furnished
room
temperature,
thereby
demonstrating
broad
utility
functional-group
tolerance
this
protocol.
Mechanistic
studies
disclosed
that
B2cat2
serves
as
both
reagent
cathodic
mediator,
enabling
difficult-to-reduce
bromides
or
chlorides
low
potential.
Chemistry - A European Journal,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 22, 2025
Abstract
Chlorinated
polymers
have
made
enormous
contributions
to
materials
science
and
are
commercially
produced
on
a
large
scale.
These
chlorinated
could
be
recycled
as
chlorine
sources
efficiently
produce
valuable
compounds
owing
their
facile
release
of
HCl.
Although
the
thermal
stability
PVDC
is
low
compared
PVC,
this
can
advantageous
in
terms
easy
fast
dehydrochlorination.
Herein,
we
report
an
efficient
electrochemical
chlorination
using
poly(vinylidene
chloride)
(PVDC)
source
that
works
undivided
cell
applies
good
number
examples.
This
method
commodity
such
waste
PVDC‐PVC
pharma
blister
film,
PVDC‐PO
multilayer
food
packaging,
compression
molded
sheets
Ixan
(with
heat
stabilizer)
with
similar
efficiency.
Furthermore,
also
provides
dechlorination
up
98
%,
leading
unsaturated
dechlorinated
material.
Converting
into
more
stable
compounds,
harmful
chlorine‐containing
gases
during
incineration
minimized.
Additionally,
not
only
restricted
batch
processes
but
electroflow
process
for
electrosynthesis
has
been
demonstrated.
Journal of the American Chemical Society,
Journal Year:
2021,
Volume and Issue:
143(33), P. 12985 - 12991
Published: Aug. 10, 2021
Herein,
a
fast,
scalable,
and
transition-metal-free
borylation
of
alkyl
halides
(X
=
I,
Br,
Cl)
enabled
by
electroreduction
is
reported.
This
process
provides
an
efficient
practical
access
to
primary,
secondary,
tertiary
boronic
esters
at
high
current.
More
than
70
examples,
including
the
late-stage
natural
products
drug
derivatives,
are
furnished
room
temperature,
thereby
demonstrating
broad
utility
functional-group
tolerance
this
protocol.
Mechanistic
studies
disclosed
that
B2cat2
serves
as
both
reagent
cathodic
mediator,
enabling
difficult-to-reduce
bromides
or
chlorides
low
potential.
