Catalysis Activity and Chemoselectivity Control with the Trans Ligand in Ru-H Pincer Complexes

Dalton Transactions, Journal Year: 2025, Volume and Issue: 54(7), P. 2851 - 2859

Published: Jan. 1, 2025

(PhPNHP)Ru(H)(Cl)(CO) serves as a precatalyst to variety of important catalytic transformations but most improvements have been restricted the replacement CO ligand cis hydride or changing Ph groups pincer for other aryl alkyl groups. The trans is often another and studies that utilize ligands in catalysis are limited. In this work, we synthesized series [(PhPNHP)Ru(H)(CO)(L)][BPh4] complexes bearing isonitrile, PMe3, N-heterocyclic Ru-H. We compared new abilities catalyze transfer hydrogenation ketones. found all improved chemoselectivity stability catalysts; strong π-accepting resulted poor activities whereas σ-donating accelerated catalysis.

Language: Английский

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Dual Relay Rh-/Pd-Catalysis Enables β-C(sp3)-H Arylation of α-Substituted Amines

Chemical Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A dual relay catalytic protocol, built on reversible dehydrogenation of amines by Rh catalysis and C-H functionalisation transient imines Pd catalysis, is reported to enable regioselective arylation at their unactivated β-C(sp3)-H bond. Notably, the new strategy applicable secondary anilines N-PMP-protected primary aliphatic intermediate steric demands, which in contrast existing strategies that involve either free-amine-directed activation for highly sterically hindered or steric-controlled migrative cross-coupling unhindered N-Boc protected amines. Regioselectivity reaction imposed electronic effects imine intermediates rather than between specific starting materials catalysts, thereby opening uncharted scope In a broader sense, this study demonstrates opportunities involving hydrogen borrowing chemistry, previously explored alcohols, execute otherwise challenging transformations amines, commonly present natural products, pharmaceuticals, biologically active molecules, functional materials.

Language: Английский

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Dynamic kinetic resolution and dynamic kinetic asymmetric transformation of atropisomeric biaryls

Chem Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 101329 - 101329

Published: March 1, 2025

Language: Английский

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Borrowing Hydrogen and Acceptorless Dehydrogenative Coupling in the Multicomponent Synthesis of N‐Heterocycles: A Comparison between Base and Noble Metal Catalysis

European Journal of Organic Chemistry, Journal Year: 2021, Volume and Issue: 2021(46), P. 6206 - 6223

Published: Nov. 4, 2021

Abstract Acceptorless dehydrogenative coupling reactions (ADC) and hydrogen transfer strategies (HT) provide a powerful tool in the multicomponent formation of N ‐ heterocycles. A broad variety complex products can be obtained starting from simple, cheap commercially available reagents. The protocols are highly atom‐efficient, as water, dihydrogen, or some cases peroxide, only by‐products. Moreover, neither further reducing oxidizing agents, nor external general required. Especially base metal‐catalyzed become ever more important. Therefore, recent years, various different manganese, iron, cobalt, nickel copper catalysts have been developed. This Minireview highlights progress that has made by using abundant metal complexes to promote cyclizations for heterocycles compares their performance with noble catalyst systems.

Language: Английский

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Reusable Co-nanoparticles for general and selective N-alkylation of amines and ammonia with alcohols

Chemical Science, Journal Year: 2021, Volume and Issue: 13(1), P. 111 - 117

Published: Nov. 29, 2021

A general cobalt-catalyzed

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