“Neuroinflammation”: does it have a role in chronic pain? Evidence from human imaging

Pain, Journal Year: 2024, Volume and Issue: 165(11S), P. S58 - S67

Published: Oct. 14, 2024

Abstract Despite hundreds of studies demonstrating the involvement neuron-glia-immune interactions in establishment and/or maintenance persistent pain behaviors animals, role (or even occurrence) so-called “neuroinflammation” human has been an object contention for decades. Here, I present results multiple positron emission tomography (PET) measuring levels 18 kDa translocator protein (TSPO), a putative neuroimmune marker, individuals with various conditions. Overall, these suggest that brain TSPO PET signal: (1) is elevated, compared to healthy volunteers, chronic low back (with additional elevations spinal cord and neuroforamina), fibromyalgia, migraine other conditions characterized by pain; (2) spatial distribution exhibiting degree disorder specificity; (3) parametrically linked characteristics or comorbid symptoms (eg, nociplastic pain, fatigue, depression), as well measures function (ie, functional connectivity), regionally-specific manner. In this narrative, also discuss important caveats consider interpretation work regarding cellular source signal complexities inherent its acquisition analysis). While biological clinical significance findings awaits further work, emerging preclinical literature supports possible pathophysiological underpinnings pain. Gaining deeper understanding would likely have practical implications, possibly paving way novel interventions.

Language: Английский

[18F]QTFT, a nicotinate-based radiotracer targeting P2Y12 with satisfactory blood‒brain barrier (BBB) permeability

Acta Pharmaceutica Sinica B, Journal Year: 2025, Volume and Issue: 15(2), P. 1202 - 1204

Published: Feb. 1, 2025

Language: Английский