Stationary DNA Origami Register Drives Fast Sequential DNA Computing DOI Creative Commons
Pu Deng, Jiahao Lin,

Wei Sun

et al.

ACS Central Science, Journal Year: 2024, Volume and Issue: 10(12), P. 2185 - 2187

Published: Dec. 11, 2024

InfoMetricsFiguresRef. ACS Central ScienceASAPArticle This publication is Open Access under the license indicated. Learn More CiteCitationCitation and abstractCitation referencesMore citation options ShareShare onFacebookX (Twitter)WeChatLinkedInRedditEmailJump toExpandCollapse First ReactionsDecember 11, 2024Stationary DNA Origami Register Drives Fast Sequential ComputingClick to copy article linkArticle link copied!Solid-state origami registers, integrating liquid-phase circuits, enable faster, scalable, reliable molecular computations.Pu DengPu DengKey Laboratory for Physics Chemistry of Nanodevices, School Electronics, Peking University, Beijing, China, 100871More by Pu DengJiahao LinJiahao LinKey Jiahao LinWei Sun*Wei SunKey 100871*E-mail: [email protected]More Wei Sunhttps://orcid.org/0000-0003-4145-1994Open PDFACS ScienceCite this: Cent. Sci. 2024, XXXX, XXX, XXX-XXXClick citationCitation copied!https://pubs.acs.org/doi/10.1021/acscentsci.4c02006https://doi.org/10.1021/acscentsci.4c02006Published December 2024 Publication History Published online 11 2024newsPublished American Chemical Society. licensed CC-BY 4.0 . License Summary*You are free share (copy redistribute) this in any medium or format adapt (remix, transform, build upon) material purpose, even commercially within parameters below:Creative Commons (CC): a Creative license.Attribution (BY): Credit must be given creator.View full license*DisclaimerThis summary highlights only some key features terms actual license. It not has no legal value. Carefully review before using these materials. underCC-BY share(copy adapt(remix, below: Attribution *DisclaimerThis creator. View PublicationsPublished SocietySubjectswhat subjectsArticle subjects automatically applied from Subject Taxonomy describe scientific concepts themes article.Amorphous materialsCircuitsComputational chemistryDNA origamiGeneticsUnlike semiconductor electronics, computing leverages unique base-pairing recognition specificity strands perform complex information processing at level. (1−4) Early demonstrations highlighted DNA's potential parallel computation storage chaotic liquid environments, motivating exploration beyond silicon chips. (2) Research soon transitioned functional systems, such as logical gates machines. (3,4) Currently, applications fields like processing, robotics, therapeutics, etc., (5−9) driven biocompatibility efficiency. However, increasing computational complexity scalability remain experimentally challenging, owing its unconfined diffusion-based mechanism. The use registers reaction solution offers spatial confinement addressability store direct circuit interactions, resulting reduced signal decay interference. marks an exciting step forward case complexity. (10) Yet, reliance on solution-based data transfer remains obstacle practical application computing, especially when multiple steps involved.The authors integrate solid-state which affixed glass surface, circuits strand displacement reactions.In issue Science, Fan, Wang, Lv, Jia, co-workers present novel approach address issues creating register. (1) Specifically, reactions (Figure 1). stationary while written, read, rewritten. Through innovative architecture, does register retain computation, but it also integrates rapid interactions liquid–solid interface. As result, design simplifies need physical movement reduces transmission time several hours less than hour.Figure 1Figure 1. Mechanism writing reading with registers. Reproduced permission ref (1). Copyright Society.High Resolution ImageDownload MS PowerPoint SlideFurthermore, introducing mismatches three distinct positions (L, M, R), engineer energy conformation molecules used Converter accelerating downstream processing. amplification rates all Converters have been largely improved compared original design, M Convertor presents best signal-to-noise ratio. adaptor converts amplifies 1 nM trace signals 100-fold, significantly breaking previous limit 10 nM. Finally, work successfully demonstrates two-layer sequential circuit, OR gate feeding into switch, showcasing ability integrated system execute rapidly reliably 2a).Figure 2Figure 2. Solid-state reduce hour. a. Schematic illustration connected b. Dynamics Out1 Out2 intensity changes during operation. improves 35 min. c. Comparison versus PEG- MB-mediated SlideThis hour.This tackles diffusion-limited challenge leveraging improve speed sensitivity. By reducing enhancing amplification, achieves significant boost overall efficiency 2b c). Building foundation, logic was constructed, versatility advanced computations.By efficiency.Despite improvements, limitations remain. highly dependent stable environmental conditions, temperature buffer composition, ensure correct interactions. Deviations conditions may lead loss misinterpretation. Moreover, demonstrated here serves effective proof concept, further research necessary assess more tasks.Ultimately, study milestone evolution DNA-based highlighting remarkable future advancements. stationary, rewritable platform, lays groundwork development compact scalable systems. Additionally, simplifying flow through immobilized eliminating moving elements clear path integration microfluidic paving way increased automation. Furthermore, precise nanometer-scale enables positioning heterogeneous molecules. Coupled real-time, single-molecule fluorescence imaging, allows detailed observation addressable release dynamics, providing solid foundation high-throughput analysis dynamics. These advances particularly inspiring toward creation next-generation miniaturized devices, nanotechnology, biomedical engineering, other domains requiring molecular-level calculations storage.This advancements.Author InformationClick section linkSection copied!Corresponding AuthorWei Sun - Key 100871; https://orcid.org/0000-0003-4145-1994; Email: protected]AuthorsPu Deng 100871Jiahao Lin 100871Author ContributionsP. D. J. L. contributed equally work.AcknowledgmentsClick copied!P. D., L., W. S. acknowledge National R&D Program China (2021YFF1200300, 2023YFA0915200), Beijing Natural Science Foundation (grant no. JQ20007), nos. T2125001, 21875003, 21991134), University financial support.ReferencesClick copied! references publications. 1Zhang, Q.; Li, M.; Tang, Y.; Zhang, J.; Sun, C.; Hao, Cheng, Xie, X.; S.; H.; F.; C. High-Speed Computing Using Solid-State Register. 2024. DOI: 10.1021/acscentsci.4c01557 Google ScholarThere corresponding record reference.2Adleman, Molecular Computation Solutions Combinatorial Problems. 1994, 266 (5187), 1021– 1024, 10.1126/science.7973651 Scholar2Molecular solutions combinatorial problemsAdleman, Leonard M.Science (Washington, C.) (1994), 1021-4CODEN: SCIEAS; ISSN:0036-8075. (American Association Advancement Science) tools mol. biol. were solve instance directed Hamiltonian problem. A small graph encoded mols. DNA, "operations" performed std. protocols enzymes. expt. feasibility carrying out computations >> SciFinder ®https://chemport.cas.org/services/resolver?origin=ACS&resolution=options&coi=1%3ACAS%3A528%3ADyaK2MXitFSjs7k%253D&md5=8b18e73879ada83af010d4dd5b4a59393Qian, L.; Winfree, E. Scaling Up Digital Circuit Strand Displacement Cascades. 2011, 332 (6034), 1196– 1201, 10.1126/science.1200520 Scholar3Scaling CascadesQian, Lulu; ErikScience DC, United States) (2011), 1196-1201CODEN: To construct sophisticated biochem. scratch, one needs understand how simple building blocks can robustly scale up. mechanism based reversible process, exptl. digital culminating 4-bit square-root that comprises 130 strands. multilayer include thresholding catalysis every operation restoration, fast function large roughly const. switching linear propagation delays. naturally incorporates crucial large-scale circuitry, general debugging tools, prepn., abstraction hierarchy supported automated compiler. ®https://chemport.cas.org/services/resolver?origin=ACS&resolution=options&coi=1%3ACAS%3A528%3ADC%252BC3MXmslyisbg%253D&md5=cc630929817854255005d309fc9bf0404Yurke, B.; Turberfield, A.; Mills, Simmel, Neumann, DNA-Fuelled Machine Made DNA. Nature 2000, 406 (6796), 605– 608, 10.1038/35020524 Scholar4A DNA-fuelled machine made DNAYurke, Bernard; Andrew Allen P., Jr.; Friedrich Jennifer L.Nature (London) (2000), 605-608CODEN: NATUAS; ISSN:0028-0836. (Nature Publishing Group) Mol. between complementary construction nanometer length scale. For example, tags organize assembly colloidal particles, templates growth semi-conductor nanocrystals metal wires. structural own right, make ordered static arrays tiles, linked rings polyhedra. active devices possible nanomech. whose changed inducing transition chirality double helix. Melting chem. modified induced optical absorption, conformational caused binding oligonucleotides groups shown change enzymic activity ribozymes. Here we report material, 'fuel'. machine, form pair tweezers. closed opened addn. auxiliary 'fuel' DNA; each cycle produces duplex waste product. ®https://chemport.cas.org/services/resolver?origin=ACS&resolution=options&coi=1%3ACAS%3A528%3ADC%252BD3cXmtFegsLY%253D&md5=20f133b92dc97e5ab9afd719dc0bfe075Douglas, Bachelet, I.; Church, G. M. Logic-Gated Nanorobot Targeted Transport Payloads. 2012, 335 (6070), 831– 834, 10.1126/science.1214081 Scholar5A PayloadsDouglas, Shawn Ido; George (2012), 831-834CODEN: We autonomous nanorobot capable transporting payloads cells, sensing cell surface inputs conditional, triggered activation, reconfiguring structure payload delivery. device loaded variety materials organized fashion controlled aptamer-encoded gate, enabling respond wide array cues. implemented different AND demonstrate their efficacy selective regulation function. principle, nanorobots combinations antibody fragments two types cell-signaling stimulation tissue culture. Our prototype could inspire new designs selectivities cell-targeting tasks. ®https://chemport.cas.org/services/resolver?origin=ACS&resolution=options&coi=1%3ACAS%3A528%3ADC%252BC38XitFGqtb0%253D&md5=bdd00ab6a19b260cf1bcebe1c7a5267e6Zhang, Zhao, Xu, R.; Teng, Du, Miao, Lin, Han, Cancer Diagnosis Computation. Nat. Nanotechnol. 2020, 15 (8), 709– 715, 10.1038/s41565-020-0699-0 Scholar6Cancer diagnosis computationZhang, Chao; Yumeng; Xuemei; Rui; Haowen; Xiaoyan; Yuzhen; Yanyan; Hsiao-chu; DaNature Nanotechnology (2020), 709-715CODEN: NNAABX; ISSN:1748-3387. Research) cancer substantially patient survival. Recent revealed levels microRNAs serum informative biomarkers cancers. Here, designed platform anal. miRNA profiles clin. samples. classifier first trained silico Genome Atlas. followed computationally powerful implementation scheme well situ transformation method enrichment without perturbing quantity information. achieved accurate samples 22 healthy people (8) lung (14) accuracy 86.4%. envision will towards inexpensive, non-invasive disease screening, classification progress monitoring. ®https://chemport.cas.org/services/resolver?origin=ACS&resolution=options&coi=1%3ACAS%3A528%3ADC%252BB3cXhtVSgsrjF&md5=eab8147886af3ae8fd8b91a21bbda2e97Macdonald, Sutovic, Lederman, Pendri, K.; Lu, W.; Andrews, B. Stefanovic, D.; Stojanovic, N. Medium Scale Integration Logic Gates Automaton. Nano Lett. 2006, 6 (11), 2598– 2603, 10.1021/nl0620684 Scholar7Medium AutomatonMacdonald, Joanne; Yang; Marko; Harvey; Kiran; Wanhong; Benjamin Darko; Milan N.Nano Letters (2006), 2598-2603CODEN: NALEFD; ISSN:1530-6984. Society) automata increasingly tasks, game playing, unbiased test computation. now second-generation deoxyribozyme-based automaton, MAYA-II, plays complete tic-tac-toe according perfect strategy. In terminol., MAYA-II represents "medium-scale circuit", 128 gates, 32 input mols., 8 two-channel fluorescent outputs across wells. ®https://chemport.cas.org/services/resolver?origin=ACS&resolution=options&coi=1%3ACAS%3A528%3ADC%252BD28XhtVCmurfN&md5=e940fc2780011658771b1785b71e0d4c8Yin, Chao, Gao, An Intelligent Nanodevice Precision Thrombolysis. Mater. 23 (6), 854– 862, 10.1038/s41563-024-01826-y reference.9Chatterjee, G.; Dalchau, N.; Muscat, R. Phillips, Seelig, Spatially Localized Architecture Modular Computing. 2017, 12 (9), 920– 927, 10.1038/nnano.2017.127 Scholar9A spatially localized architecture modular computingChatterjee, Gourab; Neil; Richard Andrew; GeorgNature (2017), 920-927CODEN: Cells constraints control accelerate enzyme cascades signaling networks. Synthetic silicon-based circuitry similarly relies process organization principle overcoming modularity engineered circuits. create lines arranging reactive hairpins origami. Signal lengths orientations modularly combined establish universality authors' approach. Because preferentially occur neighbors, identical reused Co-localization decreases minutes diffusible components. Detailed models predictive design. anticipate motivate designs. ®https://chemport.cas.org/services/resolver?origin=ACS&resolution=options&coi=1%3ACAS%3A528%3ADC%252BC2sXht1Wlsb7I&md5=1e9dff9526ac5fd44167c30864837d6610Lv, Dong, Zuo, Chen, DNA-Based Programmable Gate Arrays General-Purpose 2023, 622 (7982), 292– 300, 10.1038/s41586-023-06484-9 reference.Cited Click copied!This yet cited publications.Download PDFFiguresReferences Get e-AlertsGet e-AlertsACS copied!https://doi.org/10.1021/acscentsci.4c02006Published 2024Published Article Views-Altmetric-Citations-Learn about metrics closeArticle Views COUNTER-compliant sum text downloads since November 2008 (both PDF HTML) institutions individuals. regularly updated reflect usage leading up last few days.Citations number articles citing article, calculated Crossref daily. Find counts.The Altmetric Attention Score quantitative measure attention received online. Clicking donut icon load page altmetric.com additional details score social media presence article. calculated.Recommended Articles FiguresReferencesAbstractHigh SlideFigure SlideReferences There 2Molecular 3Scaling 4A 5A 6Cancer 7Medium 9A reference.

Language: Английский

A Localized Scalable DNA Logic Circuit System Based on the DNA Origami Surface DOI Open Access
Zhen Tang, Shiyin Li, Chun‐Lin Chen

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2043 - 2043

Published: Feb. 26, 2025

DNA (Deoxyribonucleic Acid) logic circuit systems provide a powerful arithmetic architecture for the development of molecular computations. nanotechnology, particularly origami, provides nanoscale addressable surface systems. Although computations based on origami surfaces have received significant attention in research, there are still obstacles to constructing localized scalable Here, we developed elementary circuits by employing strand displacement reaction (SDR) realize We showed that constructed can be scaled up perform arbitrary digital computing tasks, including square root functions, full adder and subtractor. used 50% reduction number components, compared threshold strategy. further demonstrated three-satisfiability (3-SAT) problem solving disease classification implemented using circuits. expect our approach new design paradigm their applications complex mathematical diagnosis.

Language: Английский

Citations

0
Nonlinear Classifiers Based on DNA Logic Circuits for Cancer Diagnosis DOI
Chun‐Lin Chen, Zhixiang Yin, Shiyin Li

et al.

ACS Synthetic Biology, Journal Year: 2025, Volume and Issue: unknown

Published: May 22, 2025

DNA logical circuits can be applied to accurate classification of cancer status, benefiting from their excellent biocompatibility and parallelism. However, the existing diagnosis models based on logic mainly adopt a linear structure, which makes it difficult fully capture complex nonlinear distribution characteristics in disease data. In addition, cannot directly sense expression levels microRNAs (miRNAs). Here, we constructed classifier with random forest algorithm. The level miRNAs serum samples without isolating specific transmit signals module complete status. We validated performance classifiers by using miRNA diagnose adenocarcinoma, ductal lobular neoplasms, squamous cell carcinoma accuracies 95.4%, 96.6%, 97.2%, respectively. results generated showed strong agreement actual states labeled TCGA, as well algorithm, had high parallelism stability multiclassification three different cancers. This work shows great potential circuit-based diagnosis, provides new approach design efficient, accurate, intelligent integrated schemes.

Language: Английский

Citations

0
Stationary DNA Origami Register Drives Fast Sequential DNA Computing DOI Creative Commons
Pu Deng, Jiahao Lin,

Wei Sun

et al.

ACS Central Science, Journal Year: 2024, Volume and Issue: 10(12), P. 2185 - 2187

Published: Dec. 11, 2024

InfoMetricsFiguresRef. ACS Central ScienceASAPArticle This publication is Open Access under the license indicated. Learn More CiteCitationCitation and abstractCitation referencesMore citation options ShareShare onFacebookX (Twitter)WeChatLinkedInRedditEmailJump toExpandCollapse First ReactionsDecember 11, 2024Stationary DNA Origami Register Drives Fast Sequential ComputingClick to copy article linkArticle link copied!Solid-state origami registers, integrating liquid-phase circuits, enable faster, scalable, reliable molecular computations.Pu DengPu DengKey Laboratory for Physics Chemistry of Nanodevices, School Electronics, Peking University, Beijing, China, 100871More by Pu DengJiahao LinJiahao LinKey Jiahao LinWei Sun*Wei SunKey 100871*E-mail: [email protected]More Wei Sunhttps://orcid.org/0000-0003-4145-1994Open PDFACS ScienceCite this: Cent. Sci. 2024, XXXX, XXX, XXX-XXXClick citationCitation copied!https://pubs.acs.org/doi/10.1021/acscentsci.4c02006https://doi.org/10.1021/acscentsci.4c02006Published December 2024 Publication History Published online 11 2024newsPublished American Chemical Society. licensed CC-BY 4.0 . License Summary*You are free share (copy redistribute) this in any medium or format adapt (remix, transform, build upon) material purpose, even commercially within parameters below:Creative Commons (CC): a Creative license.Attribution (BY): Credit must be given creator.View full license*DisclaimerThis summary highlights only some key features terms actual license. It not has no legal value. Carefully review before using these materials. underCC-BY share(copy adapt(remix, below: Attribution *DisclaimerThis creator. View PublicationsPublished SocietySubjectswhat subjectsArticle subjects automatically applied from Subject Taxonomy describe scientific concepts themes article.Amorphous materialsCircuitsComputational chemistryDNA origamiGeneticsUnlike semiconductor electronics, computing leverages unique base-pairing recognition specificity strands perform complex information processing at level. (1−4) Early demonstrations highlighted DNA's potential parallel computation storage chaotic liquid environments, motivating exploration beyond silicon chips. (2) Research soon transitioned functional systems, such as logical gates machines. (3,4) Currently, applications fields like processing, robotics, therapeutics, etc., (5−9) driven biocompatibility efficiency. However, increasing computational complexity scalability remain experimentally challenging, owing its unconfined diffusion-based mechanism. The use registers reaction solution offers spatial confinement addressability store direct circuit interactions, resulting reduced signal decay interference. marks an exciting step forward case complexity. (10) Yet, reliance on solution-based data transfer remains obstacle practical application computing, especially when multiple steps involved.The authors integrate solid-state which affixed glass surface, circuits strand displacement reactions.In issue Science, Fan, Wang, Lv, Jia, co-workers present novel approach address issues creating register. (1) Specifically, reactions (Figure 1). stationary while written, read, rewritten. Through innovative architecture, does register retain computation, but it also integrates rapid interactions liquid–solid interface. As result, design simplifies need physical movement reduces transmission time several hours less than hour.Figure 1Figure 1. Mechanism writing reading with registers. Reproduced permission ref (1). Copyright Society.High Resolution ImageDownload MS PowerPoint SlideFurthermore, introducing mismatches three distinct positions (L, M, R), engineer energy conformation molecules used Converter accelerating downstream processing. amplification rates all Converters have been largely improved compared original design, M Convertor presents best signal-to-noise ratio. adaptor converts amplifies 1 nM trace signals 100-fold, significantly breaking previous limit 10 nM. Finally, work successfully demonstrates two-layer sequential circuit, OR gate feeding into switch, showcasing ability integrated system execute rapidly reliably 2a).Figure 2Figure 2. Solid-state reduce hour. a. Schematic illustration connected b. Dynamics Out1 Out2 intensity changes during operation. improves 35 min. c. Comparison versus PEG- MB-mediated SlideThis hour.This tackles diffusion-limited challenge leveraging improve speed sensitivity. By reducing enhancing amplification, achieves significant boost overall efficiency 2b c). Building foundation, logic was constructed, versatility advanced computations.By efficiency.Despite improvements, limitations remain. highly dependent stable environmental conditions, temperature buffer composition, ensure correct interactions. Deviations conditions may lead loss misinterpretation. Moreover, demonstrated here serves effective proof concept, further research necessary assess more tasks.Ultimately, study milestone evolution DNA-based highlighting remarkable future advancements. stationary, rewritable platform, lays groundwork development compact scalable systems. Additionally, simplifying flow through immobilized eliminating moving elements clear path integration microfluidic paving way increased automation. Furthermore, precise nanometer-scale enables positioning heterogeneous molecules. Coupled real-time, single-molecule fluorescence imaging, allows detailed observation addressable release dynamics, providing solid foundation high-throughput analysis dynamics. These advances particularly inspiring toward creation next-generation miniaturized devices, nanotechnology, biomedical engineering, other domains requiring molecular-level calculations storage.This advancements.Author InformationClick section linkSection copied!Corresponding AuthorWei Sun - Key 100871; https://orcid.org/0000-0003-4145-1994; Email: protected]AuthorsPu Deng 100871Jiahao Lin 100871Author ContributionsP. D. J. L. contributed equally work.AcknowledgmentsClick copied!P. D., L., W. S. acknowledge National R&D Program China (2021YFF1200300, 2023YFA0915200), Beijing Natural Science Foundation (grant no. JQ20007), nos. T2125001, 21875003, 21991134), University financial support.ReferencesClick copied! references publications. 1Zhang, Q.; Li, M.; Tang, Y.; Zhang, J.; Sun, C.; Hao, Cheng, Xie, X.; S.; H.; F.; C. High-Speed Computing Using Solid-State Register. 2024. DOI: 10.1021/acscentsci.4c01557 Google ScholarThere corresponding record reference.2Adleman, Molecular Computation Solutions Combinatorial Problems. 1994, 266 (5187), 1021– 1024, 10.1126/science.7973651 Scholar2Molecular solutions combinatorial problemsAdleman, Leonard M.Science (Washington, C.) (1994), 1021-4CODEN: SCIEAS; ISSN:0036-8075. (American Association Advancement Science) tools mol. biol. were solve instance directed Hamiltonian problem. A small graph encoded mols. DNA, "operations" performed std. protocols enzymes. expt. feasibility carrying out computations >> SciFinder ®https://chemport.cas.org/services/resolver?origin=ACS&resolution=options&coi=1%3ACAS%3A528%3ADyaK2MXitFSjs7k%253D&md5=8b18e73879ada83af010d4dd5b4a59393Qian, L.; Winfree, E. Scaling Up Digital Circuit Strand Displacement Cascades. 2011, 332 (6034), 1196– 1201, 10.1126/science.1200520 Scholar3Scaling CascadesQian, Lulu; ErikScience DC, United States) (2011), 1196-1201CODEN: To construct sophisticated biochem. scratch, one needs understand how simple building blocks can robustly scale up. mechanism based reversible process, exptl. digital culminating 4-bit square-root that comprises 130 strands. multilayer include thresholding catalysis every operation restoration, fast function large roughly const. switching linear propagation delays. naturally incorporates crucial large-scale circuitry, general debugging tools, prepn., abstraction hierarchy supported automated compiler. ®https://chemport.cas.org/services/resolver?origin=ACS&resolution=options&coi=1%3ACAS%3A528%3ADC%252BC3MXmslyisbg%253D&md5=cc630929817854255005d309fc9bf0404Yurke, B.; Turberfield, A.; Mills, Simmel, Neumann, DNA-Fuelled Machine Made DNA. Nature 2000, 406 (6796), 605– 608, 10.1038/35020524 Scholar4A DNA-fuelled machine made DNAYurke, Bernard; Andrew Allen P., Jr.; Friedrich Jennifer L.Nature (London) (2000), 605-608CODEN: NATUAS; ISSN:0028-0836. (Nature Publishing Group) Mol. between complementary construction nanometer length scale. For example, tags organize assembly colloidal particles, templates growth semi-conductor nanocrystals metal wires. structural own right, make ordered static arrays tiles, linked rings polyhedra. active devices possible nanomech. whose changed inducing transition chirality double helix. Melting chem. modified induced optical absorption, conformational caused binding oligonucleotides groups shown change enzymic activity ribozymes. Here we report material, 'fuel'. machine, form pair tweezers. closed opened addn. auxiliary 'fuel' DNA; each cycle produces duplex waste product. ®https://chemport.cas.org/services/resolver?origin=ACS&resolution=options&coi=1%3ACAS%3A528%3ADC%252BD3cXmtFegsLY%253D&md5=20f133b92dc97e5ab9afd719dc0bfe075Douglas, Bachelet, I.; Church, G. M. Logic-Gated Nanorobot Targeted Transport Payloads. 2012, 335 (6070), 831– 834, 10.1126/science.1214081 Scholar5A PayloadsDouglas, Shawn Ido; George (2012), 831-834CODEN: We autonomous nanorobot capable transporting payloads cells, sensing cell surface inputs conditional, triggered activation, reconfiguring structure payload delivery. device loaded variety materials organized fashion controlled aptamer-encoded gate, enabling respond wide array cues. implemented different AND demonstrate their efficacy selective regulation function. principle, nanorobots combinations antibody fragments two types cell-signaling stimulation tissue culture. Our prototype could inspire new designs selectivities cell-targeting tasks. ®https://chemport.cas.org/services/resolver?origin=ACS&resolution=options&coi=1%3ACAS%3A528%3ADC%252BC38XitFGqtb0%253D&md5=bdd00ab6a19b260cf1bcebe1c7a5267e6Zhang, Zhao, Xu, R.; Teng, Du, Miao, Lin, Han, Cancer Diagnosis Computation. Nat. Nanotechnol. 2020, 15 (8), 709– 715, 10.1038/s41565-020-0699-0 Scholar6Cancer diagnosis computationZhang, Chao; Yumeng; Xuemei; Rui; Haowen; Xiaoyan; Yuzhen; Yanyan; Hsiao-chu; DaNature Nanotechnology (2020), 709-715CODEN: NNAABX; ISSN:1748-3387. Research) cancer substantially patient survival. Recent revealed levels microRNAs serum informative biomarkers cancers. Here, designed platform anal. miRNA profiles clin. samples. classifier first trained silico Genome Atlas. followed computationally powerful implementation scheme well situ transformation method enrichment without perturbing quantity information. achieved accurate samples 22 healthy people (8) lung (14) accuracy 86.4%. envision will towards inexpensive, non-invasive disease screening, classification progress monitoring. ®https://chemport.cas.org/services/resolver?origin=ACS&resolution=options&coi=1%3ACAS%3A528%3ADC%252BB3cXhtVSgsrjF&md5=eab8147886af3ae8fd8b91a21bbda2e97Macdonald, Sutovic, Lederman, Pendri, K.; Lu, W.; Andrews, B. Stefanovic, D.; Stojanovic, N. Medium Scale Integration Logic Gates Automaton. Nano Lett. 2006, 6 (11), 2598– 2603, 10.1021/nl0620684 Scholar7Medium AutomatonMacdonald, Joanne; Yang; Marko; Harvey; Kiran; Wanhong; Benjamin Darko; Milan N.Nano Letters (2006), 2598-2603CODEN: NALEFD; ISSN:1530-6984. Society) automata increasingly tasks, game playing, unbiased test computation. now second-generation deoxyribozyme-based automaton, MAYA-II, plays complete tic-tac-toe according perfect strategy. In terminol., MAYA-II represents "medium-scale circuit", 128 gates, 32 input mols., 8 two-channel fluorescent outputs across wells. ®https://chemport.cas.org/services/resolver?origin=ACS&resolution=options&coi=1%3ACAS%3A528%3ADC%252BD28XhtVCmurfN&md5=e940fc2780011658771b1785b71e0d4c8Yin, Chao, Gao, An Intelligent Nanodevice Precision Thrombolysis. Mater. 23 (6), 854– 862, 10.1038/s41563-024-01826-y reference.9Chatterjee, G.; Dalchau, N.; Muscat, R. Phillips, Seelig, Spatially Localized Architecture Modular Computing. 2017, 12 (9), 920– 927, 10.1038/nnano.2017.127 Scholar9A spatially localized architecture modular computingChatterjee, Gourab; Neil; Richard Andrew; GeorgNature (2017), 920-927CODEN: Cells constraints control accelerate enzyme cascades signaling networks. Synthetic silicon-based circuitry similarly relies process organization principle overcoming modularity engineered circuits. create lines arranging reactive hairpins origami. Signal lengths orientations modularly combined establish universality authors' approach. Because preferentially occur neighbors, identical reused Co-localization decreases minutes diffusible components. Detailed models predictive design. anticipate motivate designs. ®https://chemport.cas.org/services/resolver?origin=ACS&resolution=options&coi=1%3ACAS%3A528%3ADC%252BC2sXht1Wlsb7I&md5=1e9dff9526ac5fd44167c30864837d6610Lv, Dong, Zuo, Chen, DNA-Based Programmable Gate Arrays General-Purpose 2023, 622 (7982), 292– 300, 10.1038/s41586-023-06484-9 reference.Cited Click copied!This yet cited publications.Download PDFFiguresReferences Get e-AlertsGet e-AlertsACS copied!https://doi.org/10.1021/acscentsci.4c02006Published 2024Published Article Views-Altmetric-Citations-Learn about metrics closeArticle Views COUNTER-compliant sum text downloads since November 2008 (both PDF HTML) institutions individuals. regularly updated reflect usage leading up last few days.Citations number articles citing article, calculated Crossref daily. Find counts.The Altmetric Attention Score quantitative measure attention received online. Clicking donut icon load page altmetric.com additional details score social media presence article. calculated.Recommended Articles FiguresReferencesAbstractHigh SlideFigure SlideReferences There 2Molecular 3Scaling 4A 5A 6Cancer 7Medium 9A reference.

Language: Английский

Citations

0