Modular, Scalable Total Synthesis of Lapparbin with a Noncanonical Biaryl Linkage DOI Creative Commons
Jie Zhang,

Longhui Yu,

Hiroshige Ogawa

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: 136(42)

Published: July 15, 2024

Abstract We report the development of a novel synthetic approach for highly strained atrop‐Tyr C‐6‐to‐Trp N‐1′ linkage, which can be executed on decagram scale using modular strategy involving palladium‐catalyzed C−H arylation followed by Larock macrocyclization. The first total synthesis lapparbin ( 1 ) was achieved applying this strategy. Furthermore, utilizing and macrocyclization, discovered in ), demonstrated to applicable various arbitrary biaryl linkages, including non‐natural types.

Language: Английский

Modular, Scalable Total Synthesis of Lapparbin with a Noncanonical Biaryl Linkage DOI Creative Commons
Jie Zhang,

Longhui Yu,

Hiroshige Ogawa

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: 136(42)

Published: July 15, 2024

Abstract We report the development of a novel synthetic approach for highly strained atrop‐Tyr C‐6‐to‐Trp N‐1′ linkage, which can be executed on decagram scale using modular strategy involving palladium‐catalyzed C−H arylation followed by Larock macrocyclization. The first total synthesis lapparbin ( 1 ) was achieved applying this strategy. Furthermore, utilizing and macrocyclization, discovered in ), demonstrated to applicable various arbitrary biaryl linkages, including non‐natural types.

Language: Английский

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