During
sleep,
the
brain
can
clear
toxins
related
to
Alzheimer’s
disease.
Compared
with
baseline
without
sleep
disorder,
subjects
disorder
have
a
1.49-fold
increased
risk
of
There
is
two-way
relationship
between
sleep/wakefulness
and
disease
pathology.
Sleep
plays
an
important
role
in
memory
consolidation.
Research
shows
that
may
impact
on
symptoms
course
Therefore,
we
need
better
understand
mechanism
cognitive
behavioral
impairment
delay
progress
by
improving
sleep.
The
individuals
higher
than
disorder;
Improving
improve
level
development
impairment;
DORA
effective
strategy
neurodegeneration
patients
Amino Acids,
Journal Year:
2024,
Volume and Issue:
56(1)
Published: Feb. 5, 2024
Abstract
Alzheimer’s
disease
(AD)
is
a
multifactorial
neurodegenerative
that
lacks
convenient
and
accessible
peripheral
blood
diagnostic
markers
effective
drugs.
Metabolic
dysfunction
one
of
AD
risk
factors,
which
leaded
to
alterations
various
metabolites
in
the
body.
Pathological
changes
brain
can
be
reflected
are
expected
explain
mechanisms
or
candidate
biomarkers.
The
aim
this
study
was
investigate
targeted
within
mouse
model,
with
purpose
exploring
mechanism
potential
Targeted
metabolomics
used
quantify
256
serum
triple
transgenic
(3
×
Tg-AD)
male
mice.
Compared
controls,
49
differential
represented
dysregulation
purine,
pyrimidine,
tryptophan,
cysteine
methionine
glycerophospholipid
metabolism.
Among
them,
adenosine,
serotonin,
N-acetyl-5-hydroxytryptamine,
acetylcholine
play
key
role
regulating
neural
transmitter
network.
alteration
S-adenosine-
l
-homocysteine,
-methionine,
trimethylamine-N-oxide
mice
served
as
indicator
risk.
results
revealed
serum,
suggesting
metabolic
periphery
may
related
disturbances
neuroinhibition,
serotonergic
system,
sleep
function,
cholinergic
gut
microbiota.
This
provides
novel
insights
into
several
pathways
AD,
presenting
avenues
for
future
research
development
Journal of Integrative Neuroscience,
Journal Year:
2024,
Volume and Issue:
23(8)
Published: Aug. 13, 2024
Sleep
disorders
are
prevalent
neurological
conditions
linked
to
neurocognitive
impairments.
Understanding
the
neuroplasticity
changes
in
hippocampus,
which
plays
a
central
role
regulating
function,
is
crucial
context
of
sleep
disorders.
However,
research
on
neurodegenerative
and
influence
hippocampal
remains
largely
unclear.
Therefore,
this
review
aims
highlight
latest
advancements
regarding
functional
during
disorders,
drawing
insights
from
clinical
preclinical
involving
sleep-deprived
animal
models.
These
articles
were
gathered
through
comprehensive
literature
searches
across
databases,
including
Google
Scholar,
PubMed,
Web
Science,
Scopus.
Maternal
deprivation
has
been
observed
cause
impairment
offspring,
along
with
protein
expression
levels
associated
neuroplasticity.
Similarly,
adult
mice
shown
affect
several
cognitive
functions
fear
extinction
without
influencing
acquisition
conditioning.
While
mechanistic
dysfunction
induced
by
maternal
limited,
it
suggests
involvement
signaling
pathways,
neurotrophic
factors,
synaptic
proteins,
inflammatory
molecules,
triggered
deprivation.
Further
studies
needed
clarify
pathways
underlying
alterations
disturbances.
ACS Chemical Neuroscience,
Journal Year:
2022,
Volume and Issue:
14(2), P. 312 - 322
Published: Dec. 28, 2022
Both
cardiovascular
diseases
(CVDs)
and
Alzheimer's
disease
(AD)
share
some
common
risk
factors
(e.g.,
age,
obesity,
oxidative
stress,
inflammation,
hypertension)
that
contribute
to
their
overlapping
pathogenesis,
indicating
a
"head-to-heart"
pathological
connection
between
CVDs
AD.
To
explore
this
potential
at
the
protein
level,
we
study
cross-seeding
(heterotypic
interactions)
CVD-associated
atrial
natriuretic
peptide
(ANP)
AD-associated
β-amyloid
(Aβ).
Collective
aggregation
cell
assays
demonstrate
of
ANP
with
different
Aβ
species
including
monomers,
oligomers,
fibrils
high
binding
affinity
(KD
=
1.234–1.797
μM)
in
dose-dependent
manner.
Such
ANP-induced
also
modifies
pathway,
fibril
morphology,
deposition
pattern
by
inhibiting
fibrillization
from
small
aggregates,
disassembling
preformed
fibrils,
alleviating
Aβ-associated
cytotoxicity.
Finally,
using
transgenic
C.
elegans
worms
express
human
muscle-specific
Aβ1–42,
can
effectively
delay
Aβ-induced
worm
paralysis,
decrease
plaques
brains,
reduce
reactive
oxygen
(ROS)
production,
confirming
its
vivo
inhibition
ability
prevent
neurodevelopmental
toxicity
worms.
This
work
discovers
not
only
new
system
two
disease-related
proteins
but
finding
possesses
biological
function
as
an
inhibitor
nonaggregated
state.
Sleep Epidemiology,
Journal Year:
2023,
Volume and Issue:
3, P. 100068 - 100068
Published: Oct. 4, 2023
We
aimed
to
compare
the
efficacy
and
safety
profiles
of
different
dosages
dual
orexin
receptor
antagonists
(DORAs)
zolpidem
on
insomnia
cognitive
function.
Databases
including
PubMed,
Embase,
Cochrane
Library,
Scopus,
Google
Scholar
were
searched
for
relevant
articles.
The
standard
mean
difference
(SMD)
was
generated
consecutive
variants.
A
dose‒response
meta-regression
model
constructed
in
RStudio
4.2.1
low,
medium
high
doses
DORAs
function
insomnia.
total
22
studies
with
8,223
subjects
included.
Compared
placebo,
low
significantly
decreased
motor
vehicle
accidents/violations
(SMD=
-0.02,
95%
CI:
-0.21
0.17
SMD=
-0.36,
-0.52
-0.20,
respectively),
whereas
increased
this
index
(SMD=0.77,
0.39
1.16
SMD=1.17,
0.62
1.72,
respectively).
In
addition,
sleep
time
(TST)
medium,
SMD=0.28,
-
0.15
0.70;
SMD=1.36,
0.87
1.86;
SMD=2.59,
1.89
3.30,
respectively.
TST
at
SMD=1.01,
0.18
1.83;
SMD=1.94,
0.46
3.43;
SMD=1.71,
0.86
2.56,
recommend
as
best
intervention
highly
effective
inducing
maintaining
without
impairing
cognition.
More
head-to-head
are
needed
extend
consolidate
our
findings.
Neuroscience and Neurological Surgery,
Journal Year:
2024,
Volume and Issue:
14(1), P. 01 - 06
Published: Feb. 8, 2024
During
sleep,
the
brain
can
clear
toxins
related
to
Alzheimer's
disease.
Compared
with
baseline
without
sleep
disorder,
subjects
disorder
have
a
1.49-fold
increased
risk
of
There
is
two-way
relationship
between
sleep/wakefulness
and
disease
pathology.
Sleep
plays
an
important
role
in
memory
consolidation.
Research
shows
that
may
impact
on
symptoms
course
Therefore,
we
need
better
understand
mechanism
cognitive
behavioral
impairment
disease,
delay
progress
by
improving
sleep.
The
individuals
higher
than
disorder;
Improving
improve
level
development
impairment;
DORA
effective
strategy
neurodegeneration
patients
Brain Behavior & Immunity - Health,
Journal Year:
2023,
Volume and Issue:
31, P. 100659 - 100659
Published: June 28, 2023
Previous
studies
have
indicated
a
close
link
between
the
inflammatory
response,
exacerbated
by
circadian
disruption
and
psychostimulants
such
as
cocaine
methamphetamine
(METH).
Indicators
of
this
inflammation
include
cortisol
acute-phase
proteins
(APPs)
like
C-reactive
protein
(CRP),
complement
C3
(C3),
serum
amyloid
A
(SAA).
The
connection
these
markers
circulating
mitochondrial
DNA
(mtDNA)
has
been
gaining
attention.
However,
specific
influence
METH
on
APP,
cortisol,
mtDNA
levels
in
mice
with
disturbed
rhythm
yet
to
be
explored,
which
is
main
aim
research.
During
sleep,
the
brain
can
clear
toxins
related
to
Alzheimer’s
disease.
Compared
with
baseline
without
sleep
disorder,
subjects
disorder
have
a
1.49-fold
increased
risk
of
There
is
two-way
relationship
between
sleep/wakefulness
and
disease
pathology.
Sleep
plays
an
important
role
in
memory
consolidation.
Research
shows
that
may
impact
on
symptoms
course
Therefore,
we
need
better
understand
mechanism
cognitive
behavioral
impairment
delay
progress
by
improving
sleep.
The
individuals
higher
than
disorder;
Improving
improve
level
development
impairment;
DORA
effective
strategy
neurodegeneration
patients
