Drug Design Development and Therapy,
Journal Year:
2024,
Volume and Issue:
Volume 18, P. 6145 - 6164
Published: Dec. 1, 2024
This
review
elucidates
the
pivotal
role
of
pyroptosis,
triggered
by
gut
microbiota,
in
development
multiple
sclerosis
(MS),
emphasizing
its
significance
within
gut-brain
axis.
Our
comprehensive
analysis
recent
literature
reveals
how
dysbiosis
microbiota
MS
patients-characterized
reduced
microbial
diversity
and
shifts
bacterial
populations-profoundly
impacts
immune
regulation
integrity
central
nervous
system
(CNS).
Pyroptosis,
an
inflammatory
form
programmed
cell
death,
significantly
exacerbates
promoting
release
cytokines
causing
substantial
damage
to
CNS
tissues.
The
facilitates
this
detrimental
process
through
metabolites
such
as
short-chain
fatty
acids
neuroactive
compounds,
or
self-structural
products
like
lipopolysaccharides
(LPS),
which
modulate
responses
influence
neuronal
survival.
highlights
potential
modulating
regulate
thereby
suggesting
that
targeting
pathway
could
be
a
promising
therapeutic
strategy
mitigate
preserve
patients
with
MS.
IP International Journal of Comprehensive and Advanced Pharmacology,
Journal Year:
2024,
Volume and Issue:
9(4), P. 236 - 247
Published: Nov. 15, 2024
Neurotransmitters
are
chemicals
that
amplify,
transmit,
and
transform
cellular
impulses,
facilitating
communication
across
the
neurological
system.
Over
last
century,
hundreds
of
these
compounds
have
been
identified,
with
continuous
study
focussing
on
their
effects
brain
health.
known
to
control
a
variety
processes,
including
emotions,
thoughts,
memory,
learning,
movement.
As
result,
abnormalities
in
neurotransmitter
levels
related
neurodegenerative
illnesses.
This
paper
seeks
explore
most
significant
neurotransmitters,
categorized
into
two
broad
groups:
canonical
noncanonical.
Additionally,
it
discusses
connection
between
neurotransmitters
key
conditions.
A
concise
review
recent
advances
detection
methods
is
also
provided,
along
insights
how
modulating
substances
may
help
restore
homeostasis.
Drug Design Development and Therapy,
Journal Year:
2024,
Volume and Issue:
Volume 18, P. 6145 - 6164
Published: Dec. 1, 2024
This
review
elucidates
the
pivotal
role
of
pyroptosis,
triggered
by
gut
microbiota,
in
development
multiple
sclerosis
(MS),
emphasizing
its
significance
within
gut-brain
axis.
Our
comprehensive
analysis
recent
literature
reveals
how
dysbiosis
microbiota
MS
patients-characterized
reduced
microbial
diversity
and
shifts
bacterial
populations-profoundly
impacts
immune
regulation
integrity
central
nervous
system
(CNS).
Pyroptosis,
an
inflammatory
form
programmed
cell
death,
significantly
exacerbates
promoting
release
cytokines
causing
substantial
damage
to
CNS
tissues.
The
facilitates
this
detrimental
process
through
metabolites
such
as
short-chain
fatty
acids
neuroactive
compounds,
or
self-structural
products
like
lipopolysaccharides
(LPS),
which
modulate
responses
influence
neuronal
survival.
highlights
potential
modulating
regulate
thereby
suggesting
that
targeting
pathway
could
be
a
promising
therapeutic
strategy
mitigate
preserve
patients
with
MS.
