Psychoactives,
Journal Year:
2024,
Volume and Issue:
3(3), P. 411 - 436
Published: Sept. 18, 2024
This
narrative
review
explores
the
utilization
of
psychedelic
states
in
therapeutic
contexts,
deliberately
shifting
focus
from
substances
back
to
experiential
phenomena
which
they
induce,
alignment
with
original
meaning
term
“mind-manifesting”.
provides
an
overview
various
used
modern
settings
and
ritualistic
indigenous
as
well
non-pharmacological
methods
that
can
arguably
induce
states,
including
breathwork,
meditation,
sensory
deprivation.
While
occurrence
mystical
experiences
seems
be
strongest
predictor
positive
outcomes,
literature
this
field
yields
several
other
psychological
processes,
such
awe,
perspective
shifts,
insight,
emotional
breakthrough,
acceptance,
re-experiencing
memories,
certain
aspects
challenging
experiences,
are
significantly
associated
change.
Additionally,
we
discuss
detail
experience-related
changes
metaphysical
self-related
beliefs
their
respective
contributions
observed
outcomes.
We
conclude
a
purely
medical
neurobiological
on
health
is
reductive
should
not
overshadow
significance
phenomenological
understanding
treating
issues
manifest
subjective
realities
human
individuals.
Addiction Biology,
Journal Year:
2024,
Volume and Issue:
29(4)
Published: April 1, 2024
Abstract
Alcohol
use
disorder
(AUD)
remains
one
of
the
most
prevalent
psychiatric
disorders
worldwide
with
high
economic
costs.
Current
treatment
options
show
modest
efficacy
and
relapse
rates
are
high.
Furthermore,
there
increases
in
gap
few
new
medications
have
been
approved
past
20
years.
Recently,
psychedelic‐assisted
therapy
psilocybin
lysergic
acid
diethylamide
has
garnered
significant
attention
AUD.
Yet,
they
require
amounts
therapist
input
due
to
prolonged
subjective
effects
(~4–12
h)
leading
costs
impeding
implementation.
Accordingly,
is
an
increasing
interest
rapid
short‐acting
psychedelic
5‐methoxy‐
N,N
‐dimethyltryptamine
(5‐MeO‐DMT).
This
paper
offers
a
first
look
at
potential
therapeutic
mechanisms
for
AUD
by
reviewing
current
literature
on
5‐MeO‐DMT.
Primarily,
5‐MeO‐DMT
able
induce
mystical
experiences
ego‐dissolution
together
psychological
flexibility
mindfulness.
could
decrease
symptoms
through
alleviation
mood‐related
comorbidities
consistent
negative
reinforcement
self‐medication
paradigms.
In
addition,
preliminary
evidence
indicates
that
modulates
neural
oscillations
might
subserve
(increases
gamma
),
mindfulness
theta
reorganization
executive
control
networks
coherence
across
frequencies)
improve
emotion
regulation
inhibition.
Finally,
animal
studies
characterized
neuroplasticity,
anti‐inflammation,
5‐HT
2A
receptor
agonism,
downregulation
metabotropic
glutamate
5
clinical
implications
comorbidities.
The
concludes
several
recommendations
future
research
establish
purported
action.
Molecular Psychiatry,
Journal Year:
2024,
Volume and Issue:
29(8), P. 2346 - 2358
Published: March 14, 2024
Abstract
Recent
studies
have
sparked
renewed
interest
in
the
therapeutic
potential
of
psychedelics
for
treating
depression
and
other
mental
health
conditions.
Simultaneously,
novel
psychoactive
substances
(NPS)
phenomenon,
with
a
huge
number
NPS
emerging
constantly,
has
changed
remarkably
illicit
drug
market,
being
their
scientific
evaluation
an
urgent
need.
Thus,
this
study
aims
to
elucidate
impact
amino-terminal
modifications
5-MeO-DMT
molecule
on
its
interactions
serotonin
receptors
transporters,
as
well
thermoregulatory
properties.
Our
findings
demonstrated,
using
radioligand
binding
methodologies,
that
all
examined
5-MeO-tryptamines
exhibited
selectivity
5-HT1AR
over
5-HT2AR.
In
fact,
computational
docking
analyses
predicted
better
interaction
pocket
compared
investigation
also
proved
these
compounds
SERT,
revealing
molecular
size
amino
group
significantly
influenced
affinity.
Subsequent
experiments
involving
uptake,
electrophysiology,
superfusion
release
assays
confirmed
5-MeO-pyr-T
most
potent
partial
5-HT
releaser
tested.
All
tested
tryptamines
elicited,
some
degree,
head
twitch
response
(HTR)
mice,
indicative
hallucinogenic
effect
mainly
mediated
by
5-HT2AR
activation.
However,
was
shown
be
implicated
effect,
activation
attenuated
HTR.
produced
higher
hypothermic
response,
5-HT1AR,
tended
exhibit
lower
highlighting
opposite
role
both
receptors.
Moreover,
although
elicited
very
low
HTR,
they
still
act
agonists.
summary,
research
offers
comprehensive
understanding
psychopharmacological
profile
various
amino-substituted
5-MeO-tryptamines,
keeping
structural
aspects
focus
accumulating
valuable
data
frame
NPS.
unique
characteristics
render
them
intriguing
molecules
mixed-action
drugs
provide
insight
within
search
non-hallucinogenic
but
ligands
therapeutical
agents.
Psychoactives,
Journal Year:
2024,
Volume and Issue:
3(3), P. 411 - 436
Published: Sept. 18, 2024
This
narrative
review
explores
the
utilization
of
psychedelic
states
in
therapeutic
contexts,
deliberately
shifting
focus
from
substances
back
to
experiential
phenomena
which
they
induce,
alignment
with
original
meaning
term
“mind-manifesting”.
provides
an
overview
various
used
modern
settings
and
ritualistic
indigenous
as
well
non-pharmacological
methods
that
can
arguably
induce
states,
including
breathwork,
meditation,
sensory
deprivation.
While
occurrence
mystical
experiences
seems
be
strongest
predictor
positive
outcomes,
literature
this
field
yields
several
other
psychological
processes,
such
awe,
perspective
shifts,
insight,
emotional
breakthrough,
acceptance,
re-experiencing
memories,
certain
aspects
challenging
experiences,
are
significantly
associated
change.
Additionally,
we
discuss
detail
experience-related
changes
metaphysical
self-related
beliefs
their
respective
contributions
observed
outcomes.
We
conclude
a
purely
medical
neurobiological
on
health
is
reductive
should
not
overshadow
significance
phenomenological
understanding
treating
issues
manifest
subjective
realities
human
individuals.
