Published: Jan. 1, 2025
Language: Английский
npj Aging, Journal Year: 2024, Volume and Issue: 10(1)
Published: April 6, 2024
Abstract The US healthcare system is at a crossroads. With an aging population requiring more care and strained facing workforce shortages, capacity issues, fragmentation, innovative solutions policy reforms are needed. This paper aims to spark dialogue collaboration among stakeholders inspire action meet the needs of population. Through comprehensive analysis impact society, this work highlights urgency addressing issue importance restructuring be efficient, equitable, responsive.
Language: Английский
Citations
59
ACS Omega, Journal Year: 2025, Volume and Issue: 10(2), P. 1864 - 1892
Published: Jan. 8, 2025
Parkinson's disease (PD) is a progressive neurodegenerative disorder that primarily affects movement. It occurs due to gradual deficit of dopamine-producing brain cells, particularly in the substantia nigra. The precise etiology PD not fully understood, but it likely involves combination genetic and environmental factors. therapies available at present alleviate symptoms do stop disease's advancement. Research endeavors are currently directed inventing disease-controlling aim inherent mechanisms PD. biomarker breakthroughs hold enormous potential: earlier diagnosis, better monitoring, targeted treatment based on individual response could significantly improve patient outcomes ease burden this disease. research an active evolving field, focusing understanding mechanisms, identifying biomarkers, developing new treatments, improving care. In report, we explore data from CAS Content Collection outline progress We analyze publication landscape offer perspective into latest expertise advancements. Key emerging concepts reviewed strategies fight evaluated. Pharmacological targets, risk factors, as well comorbid diseases explored, clinical usage products against with their production pipelines trials for drug repurposing examined. This review aims comprehensive overview advancing current about PD, define challenges, assess growth prospects stimulate efforts battling
Language: Английский
Citations
5
Cytokine & Growth Factor Reviews, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Population ageing is increasing in prevalence most developed countries. Ageing the decline of functional properties at cellular, tissue, and organ level. Biochemical changes that occur all organisms experience biological are referred to as "Hallmarks ageing". Inflammation a common denominator hallmarks ageing, being mechanistically involved age-related health consequences. Inflamm-ageing refers inflammatory immune systems which somehow drive process towards healthy or unhealthy ageing. Current evidences, support that, reversing pro-inflammatory status inflamm-ageing, able modulate associated with increased levels molecules (e.g. cytokines, chemokines), ultimately producing chronic low-grade state typically observed older individuals. It commonly accepted balance between pro- anti-inflammatory cytokines/chemokines one factors determining whether occurs. Malnutrition nutritional imbalances, highly prevalent elderly, playing role driving immunoactive molecules. In particular, malnutrition major risk factor for sarcopenia, phenomenon characterized by loss muscle mass, often basis frailty. Given close relationship there also evidence link Indeed, cytokine/chemokine elderly patients were demonstrated. The demonstration specific cytokines play modulating appetite nutrient sensing taste reception, provided further existence nutrition shaping trajectory present review will overview current supporting circulating chemokines inflammation, malnutrition.
Language: Английский
Citations
16
ACS Chemical Neuroscience, Journal Year: 2024, Volume and Issue: 15(3), P. 408 - 446
Published: Jan. 12, 2024
Aging is typified by a gradual loss of physiological fitness and accumulation cellular damage, leading to deteriorated functions enhanced vulnerability diseases. Antiaging research has long history throughout civilization, with many efforts put forth understand prevent the effects aging. Multiple strategies aiming promote healthy aging extend lifespan have been developed including lifestyle adjustments, medical treatments, social programs. A multitude antiaging medicines remedies also explored. Here, we use data from CAS Content Collection analyze publication landscape recent related treatments. We review advances delineate trends in headway knowledge practice across time, geography, development pipelines. further assess state-of-the-art approaches explore their correlations age-related The drugs outlined Well-recognized novel, currently evaluated agents summarized. Finally, clinical applications products objective this summarize current on preventive treatment field aging, outline challenges evaluate growth opportunities, order solve problems that remain.
Language: Английский
Citations
15
Seminars in Cancer Biology, Journal Year: 2024, Volume and Issue: 106-107, P. 15 - 27
Published: Aug. 26, 2024
Language: Английский
Citations
10
Foods, Journal Year: 2025, Volume and Issue: 14(3), P. 347 - 347
Published: Jan. 21, 2025
Bee pollen is characterized by an exceptional diversity and abundance of micronutrients bioactive phytochemicals. This richness remains very sparsely investigated, but accumulating evidence strongly supports a promising future for bee in human nutrition medicine. Epigenetic regulation among the most compelling biomedical topics that remain completely untapped derivative research. In our current research, we identified numerous ubiquitous compounds are consistently present this matrix, regardless its botanical geographical origins, have been well studied documented as epigenetic regulators recent years. Given relative newness both research studies within nutritional, pharmaceutical, medical sciences, review aims to bridge these valuable fields advance related experimental investigations. To best knowledge, first work has aimed comprehensively investigate modulatory potential compounds. Our findings also unveiled several intriguing phenomena, such dual effect same compound depending on cellular context or some cross-generational heritability traits. Although whole extract still lacking, study clearly indicates avenue worth further We hope constitutes foundational cornerstone investigations
Language: Английский
Citations
2
Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 356, P. 123381 - 123381
Published: Feb. 14, 2025
Language: Английский
Citations
2
npj Women s Health, Journal Year: 2025, Volume and Issue: 3(1)
Published: Feb. 25, 2025
Osteoarthritis (OA) is a chronic joint disease characterized by cartilage degradation, inflammation, and pain. While multiple factors contribute to OA development, age sex are primary risk factors, particularly affecting postmenopausal women. The dramatic increase in after menopause suggests estrogen deficiency accelerates progression. This review explores the molecular mechanisms connecting aging focusing on key genes pathways identified through RNA sequencing.
Language: Английский
Citations
2
ACS Chemical Neuroscience, Journal Year: 2024, Volume and Issue: 15(21), P. 3800 - 3827
Published: Oct. 11, 2024
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired daily functioning. The pathology of AD marked the accumulation amyloid beta plaques tau protein tangles in brain, along with neuroinflammation synaptic dysfunction. Genetic factors, such as mutations APP, PSEN1, PSEN2 genes, well APOE ε4 allele, contribute to increased risk acquiring AD. Currently available treatments provide symptomatic relief but do not halt progression. Research efforts are focused on developing disease-modifying therapies that target underlying pathological mechanisms Advances identification validation reliable biomarkers for hold great promise enhancing early diagnosis, monitoring progression, assessing treatment response clinical practice effort alleviate burden this devastating disease. In paper, we analyze data from CAS Content Collection summarize research progress We examine publication landscape insights into current knowledge advances developments. also review most discussed emerging concepts assess strategies combat explore genetic pharmacological targets, comorbid diseases. Finally, inspect applications products against their development pipelines drug repurposing. objective broad overview evolving regarding AD, outline challenges, evaluate growth opportunities further combating
Language: Английский
Citations
9
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7694 - 7694
Published: July 13, 2024
Telomeres are part of chromatin structures containing repeated DNA sequences, which function as protective caps at the ends chromosomes and prevent degradation recombination, thus ensuring integrity genome. While telomere length (TL) can be genetically inherited, TL shortening has been associated with ageing multiple xenobiotics bioactive substances. characterised a reliable biomarker for predisposition to developing chronic pathologies their progression. This narrative review aims provide arguments in favour including measurements complex prognostic diagnostic panel importance assessing effect different pharmacologically active molecules on biology telomeres. Medicines used management cardiovascular diseases, diabetes, schizophrenia, hormone replacement therapy menopause, danazol, melatonin, probiotics have studied positive effects against shortening. All these classes drugs analysed present review, particular focus molecular mechanisms involved.
Language: Английский
Citations
7