Photoswitch dissociation from a G protein-coupled receptor resolved by time-resolved serial crystallography DOI Creative Commons
Hannah Glover,

Torben Saßmannshausen,

Quentin Bertrand

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 30, 2024

G protein-coupled receptors (GPCRs) are the largest family of cell surface in humans. The binding and dissociation ligands tunes inherent conformational flexibility these important drug targets towards distinct functional states. Here we show how to trigger resolve protein-ligand interaction dynamics within human adenosine A

Language: Английский

Photopharmacology and photoresponsive drug delivery DOI Creative Commons
Yuwei Liu, Tianyi Wang, Weiping Wang

et al.

Chemical Society Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Light serves as an excellent external stimulus due to its high spatial and temporal resolution. The use of light regulate biological processes has evolved into a vibrant field over the past decade. Employing on chemical substances such bioactive molecules drug delivery systems offers promising therapeutic approach achieve precise control processes. In this review, we provide overview advancements in optochemical technologies for controlling (photopharmacology) (photoresponsive delivery), with emphasis their relationship biomedical applications. Gaining deeper understanding underlying mechanisms emerging research will facilitate development optochemically controlled photoresponsive systems, further enhancing

Language: Английский

Citations

0
A Bright Future for Photopharmaceuticals Addressing Central Nervous System Disorders: State of the Art and Challenges Toward Clinical Translation DOI
Rudolf L. Z. Ganzoni, Sofie S. Bournons, Erick M. Carreira

et al.

Medicinal Research Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: April 5, 2025

ABSTRACT Photopharmacology is an innovative approach that uses light to activate drugs. This method offers the potential for highly localized and precise drug activation, making it particularly promising treatment of neurological disorders. Despite enticing prospects photopharmacology, its application treat human central nervous system (CNS) diseases remains be demonstrated. In this review, we provide overview prominent strategies design activation photopharmaceutical agents in field neuroscience. Photocaged photoswitchable drugs bioactive molecules are discussed, instructive list examples provided highlight compound strategies. Special emphasis placed on photoactivatable compounds modulation glutamatergic, GABAergic, dopaminergic, serotonergic neurotransmission conditions, as well various photoresponsive with improved pain management. Compounds holding promise clinical translation discussed in‐depth their future applications assessed. Neurophotopharmaceuticals have yet achieve breakthrough clinic, both delivery not reached full maturity. However, by describing current state art providing illustrative case studies, offer a perspective opportunities neurophotopharmacology focused addressing CNS

Language: Английский

Citations

0
Adenosine A2A signaling in mood disorders: how far have we come? DOI Creative Commons
Laura Menegatti Bevilacqua,

Francisco da Silveira Neto,

Manuella P. Kaster

et al.

IBRO Neuroscience Reports, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

1
Photoresponsive Adenosine Derivatives for the Optical Control of Adenosine A2A Receptors in Living Cells DOI

Harufumi Suzuki,

Tomohiro Doura,

Yuya Matsuba

et al.

ACS Chemical Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

The use of photoresponsive ligands to optically control proteins interest, known as photopharmacology, is a powerful technique for elucidating cellular function in living cells and animals with high spatiotemporal resolution. adenosine A

Language: Английский

Citations

0
Kinetic Basis for the Design of Azobenzene-Based Photoswitchable A2a Adenosine Receptor Ligands DOI

Torben Saßmannshausen,

Hannah Glover, Matilde Trabuco

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(47), P. 32670 - 32677

Published: Nov. 13, 2024

Photoisomerization of ligands is a key process in the field photopharmacology. Thus, kinetics and efficiency this initial photoreaction are great importance but can be influenced by molecular environment binding pocket resulting confinement reaction pathway. In study, we investigated photoisomerization an azobenzene derivative anti-Parkinson's drug istradefylline. To identify impact pocket, ligand was examined solution bound to its target protein, A

Language: Английский

Citations

0
Photoswitch dissociation from a G protein-coupled receptor resolved by time-resolved serial crystallography DOI Creative Commons
Hannah Glover,

Torben Saßmannshausen,

Quentin Bertrand

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 30, 2024

G protein-coupled receptors (GPCRs) are the largest family of cell surface in humans. The binding and dissociation ligands tunes inherent conformational flexibility these important drug targets towards distinct functional states. Here we show how to trigger resolve protein-ligand interaction dynamics within human adenosine A

Language: Английский

Citations

0