CuII-bis(thioureido) Complex: A Potential Radiotracer for Detecting Oxidative Stress and Neuroinflammation in Neurodegenerative Diseases DOI

Weiyuan Lin,

Chia-Hsin Huang,

Z.J. Tan

et al.

Seminars in Nuclear Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Navigating Neurodegeneration: Integrating Biomarkers, Neuroinflammation, and Imaging in Parkinson’s, Alzheimer’s, and Motor Neuron Disorders DOI Creative Commons
Masaru Tanaka, Simone Battaglia, Donato Liloia

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(5), P. 1045 - 1045

Published: April 25, 2025

Neurodegenerative diseases represent a daunting global challenge, affecting millions worldwide and imposing significant clinical socioeconomic burdens [...]

Language: Английский

Citations

1
A patient-derived amyotrophic lateral sclerosis blood-brain barrier model for focused ultrasound-mediated anti-TDP-43 antibody delivery DOI Creative Commons
Joanna M. Wasielewska,

Juliana C.S. Chaves,

Mauricio Castro Cabral-da-Silva

et al.

Fluids and Barriers of the CNS, Journal Year: 2024, Volume and Issue: 21(1)

Published: Aug. 13, 2024

Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disorder with minimally effective treatment options. An important hurdle in ALS drug development the non-invasive therapeutic access to motor cortex currently limited by presence of blood-brain barrier (BBB). Focused ultrasound and microbubble (FUS

Language: Английский

Citations

4
The role of intracellular and extracellular copper compartmentalization in Alzheimer’s disease pathology and its implications for diagnosis and therapy DOI Creative Commons
Yuqi Li,

Shuang-Shuang Tan,

Di Wu

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: March 12, 2025

Copper is a trace element indispensable for cellular physiology, integral to redox balance, and constituent of enzyme active sites, thereby playing pivotal role in physiological function. Concerning the pathogenesis Alzheimer’s disease (AD), homeostatic balance copper perturbed both intracellularly extracellularly. The copper–amyloid precursor protein (APP) complex facilitates efflux from cells, leading intracellular depletion. Concurrently, extracellular associates with amyloid-beta (Aβ) plaques, precipitating copper-enriched Aβ deposition augmenting reactive oxygen species (ROS) brain tissue, which finally culminates oxidative damage. interaction between APP enhances α-secretase pathway processing while suppressing β-secretase pathway, resulting an increased production soluble (sAPP), contributes neuroinflammation tissue. Utilizing affinity application chelating agents sequester within can mitigate neurodegeneration associated AD pathology. Furthermore, use metal imaging techniques detect offers potential diagnostic tool early identification AD.

Language: Английский

Citations

0
CuII-bis(thioureido) Complex: A Potential Radiotracer for Detecting Oxidative Stress and Neuroinflammation in Neurodegenerative Diseases DOI

Weiyuan Lin,

Chia-Hsin Huang,

Z.J. Tan

et al.

Seminars in Nuclear Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0