Aspirin-triggered resolvin D1 modulates pulmonary and neurological inflammation in an IL-22 knock-out organic dust exposure mouse model DOI Creative Commons

Alissa Threatt,

Jeffery L. White,

Nathan Klepper

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 17, 2024

Agriculture dust contains many organic immunogenic compounds, and exposure is strongly associated with the development of immune-mediated chronic pulmonary diseases such as obstructive disease (COPD). Chronic from agriculture sources induces lung inflammatory has recently been linked to an increased risk developing dementia. The cytokine interleukin-22 (IL-22) established important mediator in resolution repair tissues. omega-3 fatty acid metabolite aspirin-triggered Resolvin D1 (AT-RvD1) shown efficacy modulating immune response both neurological inflammation but not explored a therapeutic exposure-induced neuroinflammation. Investigating link between IL-22 AT-RvD1 may help effective therapies for these diseases. We aimed investigate neuroinflammation, role exposure, immune-modulating applications knock-out mouse model exposure. C57BL/6J (WT) (KO) mice were repetitively exposed aqueous extract (DE) 5 days per week 3 weeks (15 total instillations) treated either once (3 injections) or times allowed recover days. observed significant DE characterized by inducible bronchus lymphoid tissue gliosis frontal areas brain. also that severity. Animals displayed reduced pathology severity gliosis. Our data demonstrate contributes crucial processes. further suggest have potential novel exposure-induced, inflammation, improving outcomes those

Language: Английский

Searching for new drugs to treat Alzheimer’s disease dementia through multiple pathways DOI
Hua Bai, Xiaoyan Feng

World Journal of Clinical Cases, Journal Year: 2024, Volume and Issue: 13(1)

Published: Nov. 6, 2024

Dementia is a group of diseases, including Alzheimer's disease (AD), vascular dementia, Lewy body frontotemporal Parkinson's metabolic dementia and toxic dementia. The treatment mainly includes symptomatic by controlling the primary accompanying symptoms, nutritional support therapy for repairing nerve cells, psychological auxiliary treatment, that improves cognitive function through drugs. Among them, drug to improve important. This review focuses on introducing commenting some recent progress in exploring drugs function, especially new AD. We discuss opportunities challenges finding developing therapeutic from aspects acetylcholinesterase, N-methyl-D-aspartate glutamate receptor, amyloid protein, tau protein chronic immune inflammation.

Language: Английский

Citations

0
Aspirin-triggered resolvin D1 modulates pulmonary and neurological inflammation in an IL-22 knock-out organic dust exposure mouse model DOI Creative Commons

Alissa Threatt,

Jeffery L. White,

Nathan Klepper

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 17, 2024

Agriculture dust contains many organic immunogenic compounds, and exposure is strongly associated with the development of immune-mediated chronic pulmonary diseases such as obstructive disease (COPD). Chronic from agriculture sources induces lung inflammatory has recently been linked to an increased risk developing dementia. The cytokine interleukin-22 (IL-22) established important mediator in resolution repair tissues. omega-3 fatty acid metabolite aspirin-triggered Resolvin D1 (AT-RvD1) shown efficacy modulating immune response both neurological inflammation but not explored a therapeutic exposure-induced neuroinflammation. Investigating link between IL-22 AT-RvD1 may help effective therapies for these diseases. We aimed investigate neuroinflammation, role exposure, immune-modulating applications knock-out mouse model exposure. C57BL/6J (WT) (KO) mice were repetitively exposed aqueous extract (DE) 5 days per week 3 weeks (15 total instillations) treated either once (3 injections) or times allowed recover days. observed significant DE characterized by inducible bronchus lymphoid tissue gliosis frontal areas brain. also that severity. Animals displayed reduced pathology severity gliosis. Our data demonstrate contributes crucial processes. further suggest have potential novel exposure-induced, inflammation, improving outcomes those

Language: Английский

Citations

0