Gram-Scalable Solvent-Free One-Pot Three-Component Synthesis of 2-Arylamino-3-Cyanopyridines DOI

Afsaneh Zonouzi,

Fatemeh Hosseinzadeh

Polycyclic aromatic compounds, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 13

Published: Oct. 21, 2024

Organic compounds that can show fluorescence are utilized for numerous applications. Scalable synthetic routes such a great part of academic as well technological investigations in this area. In addition to fluorescent properties, pyridine have been proven other applications, especially biological studies. A one-pot procedure is presented and 16 (14 new) the 2-arylamino-3-cyanopiridine family being reported first time. Analytical methods including CHN, NMR (1H 13C), IR, MS were used characterize newly compounds. They all blue green when irradiated with UV light. scalable approach also more than 95% yield obtaining these fairly facile workup.

Language: Английский

Highly efficient synthesis of isoxazolones and pyrazolones using g-C3N4·OH nanocomposite with their in silico molecular docking, pharmacokinetics and simulation studies DOI Creative Commons
Shivani Soni, Sunita Teli, Pankaj Teli

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 18, 2024

An environmentally friendly, versatile multicomponent reaction for synthesizing isoxazol-5-one and pyrazol-3-one derivatives has been developed, utilizing a freshly prepared g-C

Language: Английский

Citations

5
Antitumor Effects of Tryptanthrin on Colorectal Cancer by Regulating the Mitogen-Activated Protein Kinase Signaling Pathway and Targeting Topo I and IDO1 DOI Creative Commons

Shing-Hwa Lu,

Bao-Long Hou, Ting Wang

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: 10(3), P. 3206 - 3221

Published: Jan. 10, 2025

Tryptanthrin (TRYP) is an indole quinazoline alkaloid with a range of pharmaceutical activities, but the specific mechanism TRYP against colorectal cancer (CRC) remains obscure. The purpose this study was to evaluate antitumor effects on CRC models both in vitro and vivo further analyze its concrete mechanisms. results experiment show that effectively inhibited proliferation migration SW620 cells, arrested cell cycle at S phase, induced apoptosis. Deeply, dramatically increased expression Bax cleaved caspase 3 while decreasing Bcl-2. transcriptome sequencing implied inhibitory were closely related mitogen-activated protein kinase (MAPK) signaling pathway, western blotting verified could decrease p-Erk increase p-p38 p-Jnk. Besides, our identified topoisomerase I (Topo I) amine 2,3-dioxygenase 1 (IDO1) targets TRYP. In vivo, showed different doses significantly tumor growth mice, degrees necrosis tissues, decreased level Ki67 protein, apoptotic signal tissues. findings demonstrated CRC, mechanisms tightly connected inhibiting activity Topo IDO1 regulating MAPK pathway. Especially, it first directly inhibit arrest phase. Therefore, work established scientific basis for development

Language: Английский

Citations

0
Green procedures for synthesizing potential hNMDA receptor allosteric modulators through reduction and one-pot reductive acetylation of nitro(hetero)arenes using a superparamagnetic Fe3O4@APTMS@Cp2ZrClx (x = 0, 1, 2) nanocatalyst DOI Creative Commons
Hossein Mousavi, Behzad Zeynizadeh,

Farhad Sepehraddin

et al.

Nanoscale Advances, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

In this research, we have developed diverse strategies for synthesizing potential h NMDA receptor allosteric modulators through reduction and one-pot reductive acetylation of nitro(hetero)arenes using a mesoporous zirconocene-containing nanocatalyst.

Language: Английский

Citations

0
Comprehensive Phytochemical, Antioxidant, and Antibacterial Analysis of Vitex agnus-castus L. Essential Oil (VACEO): Insights from ADMET and Molecular Docking Studies DOI Creative Commons
Dounia Azzouni, Soukaina Alaoui Mrani,

Fadoua Bahij

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 462 - 462

Published: March 25, 2025

Background/Objectives: The phytochemical composition, antioxidant, and antibacterial properties of Vitex agnus-castus L. essential oil (VACEO), extracted from fruit harvested in the Middle Atlas region Morocco, were investigated. Methods/Results: A full chemical analysis VACEO was performed to identify principal components using GC–MS, demonstrating that caryophyllene (13.87%), 1-(4-Isopropylphenyl)-2-methylpropyl acetate (12.20%), τ-Cadinol (5.41%) most important constituents this oil. In addition, antioxidant activity evaluated DPPH, FRAP, TAC, beta-carotene bleach tests; demonstrated an IC50 0.93 ± 0.03 mg/mL (DPPH), EC50 0.146 0.004 (FRAP), a total capacity 0.794 0.02 mg BHT equivalent/g EO, with relative at 72.69 0.3%. Antibacterial assays revealed inhibition diameters ranging 13.25 1.00 mm 21.11 0.25 mm, minimum inhibitory concentrations (MICs) 0.02–0.04 against Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa. Moreover, ADMET suggested potential for drug development, specific insights into pharmacokinetics, safety, molecular docking, clarifying its interactions key bacterial proteins. Conclusions: These results confirm promising therapeutic pharmaceutical through bioactive compounds.

Language: Английский

Citations

0
Green and Tandem Synthesis of Heterocyclic α,α’‐Dibromocycloamides and Their Target Predictions and ADMET Analysis DOI
Dinesh Shinde,

Aarzoo F Qazi,

Harshal Patil

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(16)

Published: April 1, 2025

Abstract Oxy‐bromination of cyclic amines to corresponding α,α’‐dibromocycloamide(s) using bromide‐bromate couple in aqueous acetic acid and at 60 °C (oil bath) is presented the current work. A various types were successfully oxybrominated during this Separation desired product by filtration therefore avoiding need column chromatography, use as safe stable source oxy‐bromination agent, mild reaction conditions so on are merits present research method. In silico ADMET target prediction studies indicated that novel α,α’‐dibromocycloamides possess satisfactory pharmacokinetic pharmacodynamic profiles. The identified therapeutic targets provided a foundation for developing optimized molecules targeting therapeutically significant classes. HOMO‐LUMO energy calculations DFT method showed Mole 3 4 exhibited low gap demonstrated high reactivity. However, 5, 6, 7 9 found with energy, thereby producing less reactivity or stability. reactive could be potential lead which can interact efficiently drug targets. further experimental (in vitro/in vivo) necessary gain deeper insights into pharmacological activities these compounds.

Language: Английский

Citations

0
NiII-containing l-glutamic acid cross-linked chitosan anchored on Fe3O4/f-MWCNT: a sustainable catalyst for the green reduction and one-pot two-step reductive Schotten–Baumann-type acetylation of nitroarenes DOI Creative Commons
Hossein Mousavi, Behzad Zeynizadeh, Morteza Hasanpour Galehban

et al.

Nanoscale Advances, Journal Year: 2024, Volume and Issue: 6(15), P. 3961 - 3977

Published: Jan. 1, 2024

In this research, new catalytic applications of the Fe 3 O 4 / f -MWCNT-CS-Glu/Ni II nanocomposite have been introduced for efficient reduction and one-pot two-step reductive Schotten–Baumann-type acetylation nitroarenes in water.

Language: Английский

Citations

3
A new strategy for immobilization of copper on the Fe3O4@EDTA nanocomposite and its efficient catalytic applications in reduction and one-pot reductive acetylation of nitroarenes and also N-acetylation of arylamines DOI Creative Commons
Leila Mavaddatiyan, Behzad Zeynizadeh

Heliyon, Journal Year: 2024, Volume and Issue: 10(15), P. e35062 - e35062

Published: July 26, 2024

A new and efficient Cu(II)-containing mesoporous nanocatalytic system was synthesized by direct immobilization of copper metal powder on the Fe

Language: Английский

Citations

1
One-pot three-component synthesis of 2,4-dimethoxy-5,8,9,10-tetrahydropyrimido[4,5-b]quinolinone derivatives along with in silico and in vitro investigation of their antimalarial activity DOI
Bhavin Patel,

Pratik Patel,

Nirajkumar V. Shah

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1321, P. 139779 - 139779

Published: Aug. 23, 2024

Language: Английский

Citations

0
Gram-Scalable Solvent-Free One-Pot Three-Component Synthesis of 2-Arylamino-3-Cyanopyridines DOI

Afsaneh Zonouzi,

Fatemeh Hosseinzadeh

Polycyclic aromatic compounds, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 13

Published: Oct. 21, 2024

Organic compounds that can show fluorescence are utilized for numerous applications. Scalable synthetic routes such a great part of academic as well technological investigations in this area. In addition to fluorescent properties, pyridine have been proven other applications, especially biological studies. A one-pot procedure is presented and 16 (14 new) the 2-arylamino-3-cyanopiridine family being reported first time. Analytical methods including CHN, NMR (1H 13C), IR, MS were used characterize newly compounds. They all blue green when irradiated with UV light. scalable approach also more than 95% yield obtaining these fairly facile workup.

Language: Английский

Citations

0