Peroxisome Proliferator-Activated Receptors (PPARs) May Mediate the Neuroactive Effects of Probiotic Metabolites: An In Silico Approach DOI Open Access
Irving Parra, Alan Carrasco‐Carballo,

Victoria Palafox-Sánchez

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4507 - 4507

Published: May 9, 2025

It is well established that the gut-brain axis (GBA) a bidirectional communication between gut and brain. This axis, critical in maintaining overall homeostasis, regulated at neuronal, endocrine, immunological levels, all of which may be influenced by microbiota (GM). Therefore, dysbiosis or disruption GM have serious consequences including neuroinflammation due to overactivation immune system. Strategies reestablish integrity via use probiotics are being pursued as novel therapeutic intervention variety central peripheral diseases. The mechanisms leading efficacy probiotics, however, not fully evident. Here, we performed computational analysis on two major namely Lactobacillus Lacticaseibacillus rhamnosus GG (formerly named rhamnosus, L. GG) Bifidobacterium animalis spp. lactis (B. B. animalis) only shed some light their mechanism(s) action but also identify potential molecular targets for probiotics. Using PubMed web page BioCyc Database Collection platform specifically analyzed proteins affected metabolites these bacteria. Our results indicate peroxisome proliferator-activated receptors (PPARs), nuclear receptor involved regulation inflammation key mediators neuroactive effect

Language: Английский

Peroxisome Proliferator-Activated Receptors (PPARs) May Mediate the Neuroactive Effects of Probiotic Metabolites: An In Silico Approach DOI Open Access
Irving Parra, Alan Carrasco‐Carballo,

Victoria Palafox-Sánchez

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4507 - 4507

Published: May 9, 2025

It is well established that the gut-brain axis (GBA) a bidirectional communication between gut and brain. This axis, critical in maintaining overall homeostasis, regulated at neuronal, endocrine, immunological levels, all of which may be influenced by microbiota (GM). Therefore, dysbiosis or disruption GM have serious consequences including neuroinflammation due to overactivation immune system. Strategies reestablish integrity via use probiotics are being pursued as novel therapeutic intervention variety central peripheral diseases. The mechanisms leading efficacy probiotics, however, not fully evident. Here, we performed computational analysis on two major namely Lactobacillus Lacticaseibacillus rhamnosus GG (formerly named rhamnosus, L. GG) Bifidobacterium animalis spp. lactis (B. B. animalis) only shed some light their mechanism(s) action but also identify potential molecular targets for probiotics. Using PubMed web page BioCyc Database Collection platform specifically analyzed proteins affected metabolites these bacteria. Our results indicate peroxisome proliferator-activated receptors (PPARs), nuclear receptor involved regulation inflammation key mediators neuroactive effect

Language: Английский

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