Neuromodulation of Cerebral Blood Flow: A Physiological Mechanism and Methodological Review of Neurovascular Coupling DOI Creative Commons

Jiawen Zhong,

Gen Li, Zexiang Lv

et al.

Bioengineering, Journal Year: 2025, Volume and Issue: 12(5), P. 442 - 442

Published: April 23, 2025

Neurovascular coupling (NVC) refers to the dynamic regulation of cerebral blood flow via neuronal activity, a mechanism crucial for maintaining normal brain function. This review elucidates intricate physiological mechanisms underlying NVC, emphasizing coordinated roles neurons, glial cells, and vascular cells in mediating activity-induced changes flow. We examine how NVC is impaired neurological disorders such as Alzheimer’s disease stroke, where dysfunction this contributes neurodegeneration deficits. A broad range techniques assessing discussed—encompassing established modalities like transcranial Doppler, near-infrared spectroscopy, functional magnetic resonance imaging (fMRI), well emerging technologies ultrasound miniaturized endoscopy that enable high-resolution monitoring deep regions. also highlight computational modeling approaches simulating dynamics identify novel biomarkers with potential utility early diagnosis. Finally, translational applications—including neuromodulation targeted pharmacological interventions—are explored means restore neurovascular These advancements underscore clinical significance research, paving way improved diagnostic tools therapeutic strategies disorders.

Language: Английский

Neuromodulation of Cerebral Blood Flow: A Physiological Mechanism and Methodological Review of Neurovascular Coupling DOI Creative Commons

Jiawen Zhong,

Gen Li, Zexiang Lv

et al.

Bioengineering, Journal Year: 2025, Volume and Issue: 12(5), P. 442 - 442

Published: April 23, 2025

Neurovascular coupling (NVC) refers to the dynamic regulation of cerebral blood flow via neuronal activity, a mechanism crucial for maintaining normal brain function. This review elucidates intricate physiological mechanisms underlying NVC, emphasizing coordinated roles neurons, glial cells, and vascular cells in mediating activity-induced changes flow. We examine how NVC is impaired neurological disorders such as Alzheimer’s disease stroke, where dysfunction this contributes neurodegeneration deficits. A broad range techniques assessing discussed—encompassing established modalities like transcranial Doppler, near-infrared spectroscopy, functional magnetic resonance imaging (fMRI), well emerging technologies ultrasound miniaturized endoscopy that enable high-resolution monitoring deep regions. also highlight computational modeling approaches simulating dynamics identify novel biomarkers with potential utility early diagnosis. Finally, translational applications—including neuromodulation targeted pharmacological interventions—are explored means restore neurovascular These advancements underscore clinical significance research, paving way improved diagnostic tools therapeutic strategies disorders.

Language: Английский

Citations

0