Toxics,
Journal Year:
2024,
Volume and Issue:
12(10), P. 723 - 723
Published: Oct. 4, 2024
Toxicity
mechanisms
of
per-
and
polyfluoroalkyl
substances
(PFASs),
a
chemical
class
present
in
diverse
ecosystems,
as
well
many
their
precursors,
have
been
increasingly
characterized
aquatic
species.
Perfluorooctanesulfonamide
(PFOSA,
C8H2F17NO2S)
is
common
precursor
perfluorooctane
sulfonic
acid
(PFOS),
long-chain
PFAS.
Here,
we
assessed
sub-lethal
endpoints
related
to
development,
oxidative
stress,
transcript
levels,
distance
moved
zebrafish
embryos
larvae
following
continuous
exposure
PFOSA
beginning
at
6
h
post-fertilization
(hpf).
decreased
survival
fish
treated
with
1
µg/L
PFOSA;
however,
the
effect
was
modest
relative
controls
(difference
10%).
Exposure
up
10
did
not
affect
hatch
rate,
nor
it
induce
ROS
7-day-old
fish.
The
activity
larval
100
reduced
solvent
control.
Transcripts
stress
response
apoptosis
were
measured
BCL2-associated
X,
regulator
(bax),
cytochrome
c,
somatic
(cycs),
catalase
(cat),
superoxide
dismutase
2
(sod2)
induced
high
concentrations
PFOSA.
Genes
neurotoxicity
also
levels
acetylcholinesterase
(ache),
elav-like
RNA
binding
protein
3
(elavl3),
growth-associated
43
(gap43),
synapsin
II
(syn2a),
tubulin
(tubb3)
all
increased
higher
exposure.
These
data
improve
our
understanding
potential
toxicity
The
presence
of
polyhalogenated
carbazoles
(PHCZs),
which
are
emerging
as
dioxin-like
contaminants,
in
remote
polar
regions
has
not
been
reported.
This
study
investigated
11
target
PHCZs
(Σ
Ecotoxicology and Environmental Safety,
Journal Year:
2023,
Volume and Issue:
270, P. 115892 - 115892
Published: Dec. 28, 2023
Polyhalogenated
carbazoles
(PHCZs)
are
emerging
environmental
pollutants,
yet
limited
information
is
available
on
their
embryotoxicity
and
neurotoxicity.
Therefore,
the
current
work
was
performed
to
investigate
adverse
effects
of
3,6-dibromocarbazole
(3,6-DBCZ),
a
typical
PHCZs
homolog,
early
life
stages
zebrafish
larvae.
It
revealed
that
96-hour
post-fertilization
(hpf)
median
lethal
concentration
(LC
Toxicity
mechanisms
of
per-
and
polyfluoroalkyl
substances
(PFAS),
a
chemical
class
present
in
diverse
ecosystems,
are
not
well
characterized
aquatic
species.
Perfluorooctanesulfonamide
(PFOSA,
C8H2F17NO2S)
is
common
precursor
perfluorooctane
sulfonic
acid
(PFOS),
long-chain
PFAS.
Here,
we
assessed
sub-lethal
endpoints
related
to
development,
oxidative
stress,
locomotor
activity,
gene
expression
zebrafish
embryos
larvae
following
continuous
exposure
PFOSA
beginning
at
6
hours
post
fertilization
(hpf).
decreased
survival
fish
treated
with
1
µg/L
PFOSA,
however
the
effect
was
modest
relative
controls
(difference
10%).
Exposure
up
10
did
affect
hatch
rate,
nor
it
induce
reactive
oxygen
species
7-day-old
fish.
However,
activity
larval
100
reduced
solvent
control.
Transcripts
stress
response
apoptosis
were
measured
BCL2
associated
X,
regulator
(bax),
cytochrome
c,
somatic
(cycs),
catalase
(cat),
superoxide
dismutase
2
(sod2)
induced
high
concentrations
PFOSA.
Genes
neurotoxicity
also
transcript
levels
acetylcholinesterase
(ache),
elav-like
RNA
binding
protein
3
(elavl3),
growth
43
(gap43),
synapsin
II
(syn2a),
tubulin
(tubb3)
all
increased
higher
exposure.
This
study
contributes
our
knowledge
regarding
toxicity
data
future
risk
assessment
strategies
these
concerning,
persistent
environmental
pollutants.
Toxics,
Journal Year:
2024,
Volume and Issue:
12(10), P. 723 - 723
Published: Oct. 4, 2024
Toxicity
mechanisms
of
per-
and
polyfluoroalkyl
substances
(PFASs),
a
chemical
class
present
in
diverse
ecosystems,
as
well
many
their
precursors,
have
been
increasingly
characterized
aquatic
species.
Perfluorooctanesulfonamide
(PFOSA,
C8H2F17NO2S)
is
common
precursor
perfluorooctane
sulfonic
acid
(PFOS),
long-chain
PFAS.
Here,
we
assessed
sub-lethal
endpoints
related
to
development,
oxidative
stress,
transcript
levels,
distance
moved
zebrafish
embryos
larvae
following
continuous
exposure
PFOSA
beginning
at
6
h
post-fertilization
(hpf).
decreased
survival
fish
treated
with
1
µg/L
PFOSA;
however,
the
effect
was
modest
relative
controls
(difference
10%).
Exposure
up
10
did
not
affect
hatch
rate,
nor
it
induce
ROS
7-day-old
fish.
The
activity
larval
100
reduced
solvent
control.
Transcripts
stress
response
apoptosis
were
measured
BCL2-associated
X,
regulator
(bax),
cytochrome
c,
somatic
(cycs),
catalase
(cat),
superoxide
dismutase
2
(sod2)
induced
high
concentrations
PFOSA.
Genes
neurotoxicity
also
levels
acetylcholinesterase
(ache),
elav-like
RNA
binding
protein
3
(elavl3),
growth-associated
43
(gap43),
synapsin
II
(syn2a),
tubulin
(tubb3)
all
increased
higher
exposure.
These
data
improve
our
understanding
potential
toxicity
