IntechOpen eBooks,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 4, 2024
The
chapter
offers
a
thorough
overview
of
global
efforts
to
eradicate
lymphatic
filariasis
(LF)
as
public
health
issue.
It
covers
the
current
epidemiological
status,
including
LF
distribution
and
burden,
identifies
endemic
regions.
reviews
history
elimination,
highlighting
milestones
like
WHO's
2000
launch
Global
Programme
eliminate
(GPELF).
discusses
core
strategies
such
mass
drug
administration
(MDA),
vector
control,
awareness
campaigns.
Successful
case
studies
are
presented,
detailing
effective
interventions.
Innovative
technologies,
improved
diagnostics,
new
treatment
protocols
explored.
also
addresses
integrating
elimination
with
broader
initiatives
emphasizes
One
Health
approach
managing
co-infections.
outlines
future
directions,
offering
recommendations
for
stakeholders
policymakers,
stresses
importance
monitoring
frameworks
assess
intervention
impacts.
Finally,
it
highlights
role
international
collaboration
partnerships
in
achieving
goals.
Journal of Microbiological Methods,
Journal Year:
2024,
Volume and Issue:
224, P. 106998 - 106998
Published: July 15, 2024
Vaccine
development
stands
as
a
cornerstone
of
public
health
efforts,
pivotal
in
curbing
infectious
diseases
and
reducing
global
morbidity
mortality.
However,
traditional
vaccine
methods
are
often
time-consuming,
costly,
inefficient.
The
advent
artificial
intelligence
(AI)
has
ushered
new
era
design,
offering
unprecedented
opportunities
to
expedite
the
process.
This
narrative
review
explores
role
AI
development,
focusing
on
antigen
selection,
epitope
prediction,
adjuvant
identification,
optimization
strategies.
algorithms,
including
machine
learning
deep
learning,
leverage
genomic
data,
protein
structures,
immune
system
interactions
predict
antigenic
epitopes,
assess
immunogenicity,
prioritize
antigens
for
experimentation.
Furthermore,
AI-driven
approaches
facilitate
rational
design
immunogens
identification
novel
candidates
with
optimal
safety
efficacy
profiles.
Challenges
such
data
heterogeneity,
model
interpretability,
regulatory
considerations
must
be
addressed
realize
full
potential
development.
Integrating
emerging
technologies,
single-cell
omics
synthetic
biology,
promises
enhance
precision
scalability.
underscores
transformative
impact
highlights
need
interdisciplinary
collaborations
harmonization
accelerate
delivery
safe
effective
vaccines
against
diseases.
World Journal of Advanced Research and Reviews,
Journal Year:
2024,
Volume and Issue:
21(3), P. 768 - 776
Published: March 11, 2024
Wildlife
plays
a
crucial
role
as
sentinels
for
emerging
zoonotic
diseases,
serving
early
indicators
of
potential
threats
to
human
and
animal
health.
This
review
examines
the
surveillance
systems
in
USA
that
utilize
wildlife
presence
pathogens.
The
focuses
on
methodologies,
challenges,
implications
these
systems.
In
USA,
diseases
is
primarily
conducted
through
passive
surveillance,
where
carcasses
are
collected
tested
Additionally,
active
programs
target
specific
species
known
host
pathogens
or
may
be
close
contact
with
humans
domestic
animals.
These
efforts
complemented
by
use
sentinel
species,
such
birds
bats,
which
monitored
signs
disease
could
indicate
Challenges
include
vast
geographic
range
many
making
it
difficult
sample
populations
comprehensively.
diversity
habitats
presents
logistical
challenges
efforts.
Furthermore,
there
related
data
sharing
coordination
among
agencies
responsible
public
health
policy
practice
significant.
Early
detection
can
lead
timely
interventions,
vaccination
campaigns
changes
land
practices
reduce
human-wildlife
contact.
Moreover,
inform
development
predictive
models
outbreaks,
enabling
more
effective
preparedness
response
measures.
conclusion,
critical
monitoring
USA.
Continued
investment
research
essential
enhance
our
understanding
dynamics
improve
ability
protect
Poultry Science,
Journal Year:
2024,
Volume and Issue:
103(9), P. 103973 - 103973
Published: June 13, 2024
This
study
explored
the
ability
of
formic
acid
(FA)
to
replace
antibiotics
in
broiler
chicken
diets.
It
examined
how
FA
affected
chickens'
growth,
carcass
characteristics,
blood
chemistry,
and
gut
bacteria.
The
experiment
randomly
assigned
300
one-day-old
(Ross
308)
chicks
5
groups,
each
divided
into
six
replicates
with
ten
unsexed
chicks.
following
were
treatments:
1st
group,
negative
control
(NC):
only
received
a
basal
diet;
2nd
positive
(PC):
diet
supplemented
0.5
grams
Colistin®
antibiotic
per
kilogram
3rd,
4th
5th
groups
(FA2,
FA4,
FA6)
these
along
added
at
increasing
levels:
2,
4,
6
Cm3
diet,
respectively.
Results
found
no
significant
differences
live
body
weight
(LBW)
or
gain
(BWG)
between
treatment
except
for
LBW
one
week
BWG
0-1
4-5
weeks
age.
No
variations
feed
intake
(FI)
conversion
ratio
(FCR)
among
excluding
FI
FCR
1-2
treatments
significantly
impacted
traits,
dressing
percentage,
breast
meat,
thigh
spleen,
giblets,
levels
urea,
creatinine,
total
protein,
globulin,
albumin,
as
well
activity
enzymes
alanine
aminotransferase
(ALT)
aspartate
(AST)
fed
different
diets
compared
groups.
addition
antioxidant
levels.
Also,
FA2
group
had
highest
bacterial
count
(TBC).
However,
FA6
was
opposite;
it
lowest
harmful
bacteria,
such
E.
coli
Coliform.
Supplementing
improves
parameters,
activity,
bacteria
counts,
4.0
cm³
acid/kg
supplementation
promoting
optimal
health
product
quality.
Plants,
Journal Year:
2025,
Volume and Issue:
14(2), P. 216 - 216
Published: Jan. 14, 2025
In
this
work,
extracts
from
the
pulp,
peel,
and
seed
of
Manilkara
zapota
were
obtained
via
lyophilization
oven
drying.
Bromatological
analyses
performed
to
investigate
variabilities
in
nutritional
content
fruits
after
nine
post-harvest
days.
The
phytochemical
was
assessed
by
gas
chromatography
flame
ionization
detector
(GC-FID),
their
biological
performance
studied
using
vitro
antibacterial
antioxidant
assays
(DPPH
ABTS)
vivo
toxicity
models.
Molecular
docking
implemented
evaluate
interaction
between
polar
compounds
chicozapote
with
receptors
involved
pathogenesis
bacterial
strains.
Results
revealed
that
water
or
soluble
solids
did
not
vary
post-harvest.
It
demonstrated
oven-drying
approaches
influenced
insoluble,
total
dietary
fiber
digestible
carbohydrates
among
samples.
According
GC-FID
analysis,
it
observed
methods
also
altered
myristic
pentadecanoic
acids
extracts.
noted
activities
weak
due
MIC
(>1000
μg/mL)
IC50
(>2000
values.
Still,
poor
against
Artemia
salina
nauplii.
silico
evaluation
unveiled
M.
possess
a
high
binding
affinity
towards
DNA
gyrase
B
cultured
This
study
expands
scientific
evidence
regarding
influence
distinct
extraction
on
nutraceutical
native
importance
considering
additional
enhance
bioactivities.
Zoonotic Diseases,
Journal Year:
2025,
Volume and Issue:
5(1), P. 5 - 5
Published: March 6, 2025
Zoonotic
diseases
pose
a
significant
global
health
threat,
driven
by
factors
such
as
globalization,
climate
change,
urbanization,
antimicrobial
resistance
(AMR),
and
intensified
human–animal
interactions.
The
increasing
interconnectedness
of
human,
animal,
environmental
underscores
the
importance
OH
paradigm
in
addressing
zoonotic
threats
globalized
world.
This
review
explores
complex
epidemiology
diseases,
challenges
associated
with
their
management,
necessity
for
cross-sector
collaboration
to
enhance
prevention
control
efforts.
Key
public
strategies,
including
surveillance
systems,
infection
measures,
community
education
programs,
play
crucial
roles
mitigating
outbreaks.
However,
gaps
governance,
resource
allocation,
interdisciplinary
cooperation
hinder
effective
disease
particularly
low-
middle-income
countries
(LMICs).
To
illustrate
effectiveness
approach,
this
highlights
successful
PREDICT
project,
Rwanda’s
National
One
Health
Program,
EcoHealth
Alliance,
Rabies
Elimination
Program
Philippines.
These
initiatives
demonstrate
how
integrating
efforts
can
early
detection,
improve
outbreak
responses,
reduce
burdens.
Strengthening
enhancing
infrastructure,
regulating
use,
investing
research
technological
innovations
are
essential
steps
toward
risks.
Ultimately,
coordinated,
multidisciplinary
approach
is
vital
dynamic
posed
ensuring
security
an
increasingly
interconnected
Applied Organometallic Chemistry,
Journal Year:
2025,
Volume and Issue:
39(4)
Published: March 20, 2025
ABSTRACT
Organyltellurium(IV)
complexes
have
attracted
significant
attention
due
to
their
structural
versatility
and
promising
biological
applications.
In
this
study,
a
series
of
novel
organyltellurium(IV)
with
5‐substituted
furan‐based
ligands
were
designed,
synthesized,
evaluated
for
antioxidant,
antimicrobial,
anti‐inflammatory
properties.
The
synthesized
compounds
characterized
by
ultraviolet–visible
(UV–Vis),
FT‐IR,
1
H‐NMR,
13
C‐NMR,
mass
spectrometry,
molar
conductance,
elemental
analysis,
powder
X‐ray
diffraction
thermal
analyses
which
states
that
the
bidentate
Schiff
base
ligand
(MeF4AP)
coordinated
via
oxygen
nitrogen
atom
tellurium
giving
hexa‐coordinated
tellurium(IV)
complexes.
silico
studies,
including
molecular
docking,
density
functional
theory
(DFT)
calculations,
MESP
ADME
profiling
provided
insights
into
stability,
electronic
properties,
pharmacokinetic
potential.
DPPH
BSA
assays
revealed
3c
(IC₅₀
=
4.95
±
0.02
μM),
3b
7.12
0.07
μM
3f
4.14
0.11
μM)
exhibited
highest
antioxidant
activity
compared
ligand.
Notably,
complex
MIC
0.20
mg/mL
against
Candida
albicans
nearly
twice
as
potent
standard
drug
griseofulvin
(MIC
0.50
mg/mL).
FMO
studies
supports
more
bioactivity
base.
displayed
most
reactive
regions.
strong
correlation
between
computational
predictions
in
vitro
results
highlights
potential
these
multifunctional
therapeutic
candidates
pave
way
further
exploration
biomedical
