Veterinary Sciences,
Journal Year:
2024,
Volume and Issue:
11(10), P. 515 - 515
Published: Oct. 20, 2024
Since
the
development
of
dairy
farming,
bovine
mastitis
has
been
a
problem
plaguing
whole
industry,
which
led
to
decrease
in
milk
production,
reduction
product
quality,
and
an
increase
costs.
The
use
antibiotics
treat
can
cause
series
problems,
bring
harm
animal
itself,
such
as
bacterial
resistance
dramatic
changes
gut
flora.
However,
vivo
vitro
antibacterial
activity
yak
Interleukin-22
(IL-22)
its
application
caused
by
Frontiers in Aging Neuroscience,
Journal Year:
2024,
Volume and Issue:
16
Published: Aug. 26, 2024
The
blood-brain
barrier
is
known
to
consist
of
a
variety
cells
and
complex
inter-cellular
junctions
that
protect
the
vulnerable
brain
from
neurotoxic
compounds;
however,
it
also
complicates
pharmacological
treatment
central
nervous
system
disorders
as
most
drugs
are
unable
penetrate
on
basis
their
own
structural
properties.
This
dramatically
diminished
therapeutic
effect
drug
compromised
its
biosafety.
In
response,
number
often
delivered
lesions
in
invasive
ways
bypass
obstruction
barrier,
such
subdural
administration,
intrathecal
convection-enhanced
delivery.
Nevertheless,
these
intrusive
strategies
introduce
risk
injury,
limiting
clinical
application.
recent
years,
intensive
development
nanomaterials
science
interdisciplinary
convergence
medical
engineering
have
brought
light
penetration
for
brain-targeted
drugs.
this
paper,
we
extensively
discuss
limitations
delivery
non-invasive
nanomedicine
disruption.
meantime,
analyze
strengths
provide
outlooks
further
systems.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2025,
Volume and Issue:
15
Published: April 29, 2025
Microbial
dysbiosis
links
to
mucosal
immune
dysregulation,
but
the
specific
bacterial
contributions
oral
inflammation
remain
unclear.
Escherichia
coli
(E.
coli),
a
pathogen
well-characterized
in
immunity
and
regulation
studies,
has
been
observed
be
enriched
chronic
inflammatory
lesions
was
reported
modulate
T
helper
17
cells
(Th17)/T
regulatory
(Treg)
homeostasis.
Here,
we
developed
an
mucositis
mouse
model
via
tongue
scratch
E.
topical
application
investigate
its
role
Th17/Treg
imbalance.
The
infiltration
evaluated
by
macroscopic
photography
HE
staining.
expression
of
factors
tissue
peripheral
blood
mice
were
detected
immunohistochemical
staining
enzyme-linked
immunosorbent
assay.
number
Th17
Treg
spleen
lymphocytes
with
flow
cytometry.
Differential
gene
analysis,
functional
enrichment
analysis
performed
using
RNA-seq
data
from
lichen
planus
(OLP).
stimulation
aggravated
responses
induced
scratching
lingual
mucosa
mice,
including
increased
local
systemic
interleukin
6
(IL6),
(IL17),
chemokine
receptor
(CCR6)
C-C
motif
ligand
20
(CCL20),
proportions
ratio
lymphocytes.
Analysis
OLP
revealed
alterations
antimicrobial
associated
upregulation
balance.
This
study
supports
promoting
provides
experimental
basis
for
vivo
perspective
microorganisms.
