Nucleoside antiviral agents with atypical structures and new targets

Bioorganic & Medicinal Chemistry Letters, Journal Year: 2025, Volume and Issue: 119, P. 130110 - 130110

Published: Jan. 27, 2025

Language: Английский

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Development of a Scalable Manufacturing Process for AB-343 Drug Substance: A Potential Candidate for the Treatment of Coronavirus Infections

Organic Process Research & Development, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Language: Английский

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Switchable and Stereospecific C-Glycosylation Strategy via Formal Functional Group Deletion

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Carbohydrates constitute an important class of biologically relevant natural products. Among the synthetic glycomimetics, C-glycosides are particularly interesting due to their chemical and metabolic stability toward acidic enzymatic hydrolysis at anomeric position. The stereochemical outcomes traditional methodologies access rely heavily on substrate control. Herein, we report a novel strategy diverse with precise control position via formal functional group deletion, where both α- β-anomers furanoses pyranoses can be obtained as single stereoisomers. Additionally, broad scope heterocyclic this further illustrates its potential for empowering future application in biology research drug discovery.

Language: Английский

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Unraveling the anti-dengue viral potential of protease inhibitors from Streptomyces spp.

Chemistry Africa, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Language: Английский

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Biological Characterization of AB-343, a Novel and Potent SARS-CoV-2 Mpro Inhibitor with Pan-Coronavirus Activity

Antiviral Research, Journal Year: 2024, Volume and Issue: unknown, P. 106038 - 106038

Published: Nov. 1, 2024

Language: Английский

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