Do policies that allow access to unregistered antimicrobials address the unmet need? Australia as a case study of a high-income country with universal healthcare DOI Creative Commons
Nadine Hillock, Allen C. Cheng,

Andrew Bowskill

et al.

JAC-Antimicrobial Resistance, Journal Year: 2024, Volume and Issue: 7(1)

Published: Dec. 26, 2024

Ensuring timely and equitable access to effective optimal antimicrobials is crucial for patient care, minimize the use of less appropriate treatment options reduce risk antimicrobial resistance (AMR). To determine average time new antibacterials gain registration in Australia after obtaining marketing approval internationally, quantify 'new' older unregistered Australian clinical practice between 2018 2023. Two data sources were utilized estimate usage not registered Australia. Annual hospital inpatient sourced from National Antimicrobial Utilisation Surveillance Program (NAUSP) on Special Access Scheme (SAS) applications was Government Department Health Aged Care. Between 2023 there 36 131 unapproved In 26.6% cases, an a critically ill patient. Levofloxacin, pyrazinamide, tetracycline pristinamycin most frequently accessed antimicrobials. Applications increased 55 249 Inpatient nine reported hospitals 2023, two seven unregistered. Unapproved are by clinicians patients unable be treated with Policy reform economic incentives required support needed otherwise untreatable infections ensure sustainability supply.

Language: Английский

Antibacterials with Novel Chemical Scaffolds in Clinical Development DOI Creative Commons
Dominik Heimann,

Daniel Kohnhäuser,

Alexandra Jana Kohnhäuser

et al.

Drugs, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Language: Английский

Citations

1
Novel Antibacterial Agents and Emerging Therapies in the Fight Against Multidrug-Resistant Acinetobacter baumannii DOI
Elijah Kolawole Oladipo, Stephen Feranmi Adeyemo,

Glory Jesudara Oluwasanya

et al.

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: 200, P. 107361 - 107361

Published: Jan. 31, 2025

Language: Английский

Citations

0
Exploring of Antibacterial Compounds from Mangrove Endophytic Fungus Aspergillus Sydowii 22plp1-F1 Through Osmac and Computational Approach to Combat Multidrug-Resistant Bacteria DOI
Fendi Setiawan, Wawan Abdullah Setiawan, Ni Luh Gede Ratna Juliasih

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Discovery of Phototoxic Metal Complexes with Antibacterial Properties via a Combinatorial Approach DOI Creative Commons
Timothy Kench,

N Chowdhury,

Khondaker Miraz Rahman

et al.

Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Antimicrobial resistance is one of the biggest global healthcare challenges. Therefore, there an urgent need to develop new molecules that display distinct antibacterial properties overcome resistance. With this aim, we have developed a combinatorial and semiautomated platform synthesize screen library 78 compounds against Gram-positive Gram-negative bacteria. This based on octahedral iridium(III) complexes with general formula [Ir(CN)2(NN)]Cl (where CN are cyclometallating polyaromatic ligands NN phenanthroline-imidazole or dipyridophenazine derivatives) which known generate reactive oxygen species (ROS) upon light irradiation. From initial entire (in dark under irradiation) Escherichia coli Staphylococcus aureus, show scaffold highly effective at inhibiting growth bacteria intermediate dose (16 μg/mL), displaying hit rate >30% in rising 56% Six were selected for further studies panel five strains, allowing us identify two lead MICs as low 2 μg/mL. These studied more detail establish their mode action using time-kill study S. aureus USA300 strain.

Language: Английский

Citations

0
Novel drugs for the management of recalcitrant erythema nodosum leprosum DOI Open Access
Mayra Ianhez, Ciro Martins Gomes, A Grana

et al.

Journal of the European Academy of Dermatology and Venereology, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

Citations

0
A safety and absolute activity measurement method for Phi29 DNA polymerase based on chemiluminescent detection of dATP consumption DOI
Xue‐Feng Wang, Ping Gui, Xiao Li

et al.

Analytica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 343952 - 343952

Published: March 1, 2025

Language: Английский

Citations

0
Synergistic Effects of Selected Nonthermal Technologies Combined with Soursop Leaf Extract on the Quality and Shelf Life of Refrigerated Pacific White Shrimp DOI Creative Commons
Abubakar Saleh Ahmad, Thanasak Sae‐leaw, Yadong Zhao

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(8), P. 1388 - 1388

Published: April 17, 2025

The effectiveness of multi-targeted treatments including pulsed electric field (PEF), soursop leaf extract (SLE), vacuum impregnation (VI), and modified atmosphere packaging (MAP), with without cold plasma (CP) treatment, on the quality shelf life Pacific white shrimp (Penaeus vannamei) during refrigerated storage for 21 days was investigated. PEF inhibited melanosis reduced initial bacterial load, as evidenced by lower scores total counts in treated samples. Integrating 1% SLE through VI effectively lowered color alteration, retarded melanosis, preserved textural integrity SLE-treated samples (p < 0.05). SLE1 (1%) significantly lipid oxidation, witnessed thiobarbituric acid reactive substances 0.05) minimal fatty profile changes. MAP3, comprising CO2/N2/Ar (60%/30%/10%), combined CP ensured microbiological maintained viable count within acceptable limit (6 Log CFU/g) throughout time days. Notably, PEF-SLE1-VI-MAP3-CP sample exhibited superior preservation, shown a pH volatile base content than others. Sensory evaluation confirmed that remained sensorially storage. Thus, this multi-hurdle approach demonstrated synergistic potential integrating nonthermal processing technologies plant extracts, contributing to extended safety up

Language: Английский

Citations

0
Synthesis and antibacterial activity of 3-(arylazo)indoles and related azoheterocycles DOI
Christopher L. King,

Puppala Sathish,

Danielle N. Turner

et al.

Bioorganic & Medicinal Chemistry Letters, Journal Year: 2025, Volume and Issue: unknown, P. 130256 - 130256

Published: April 1, 2025

Language: Английский

Citations

0
Risk of Underexposure and Lack of Efficacy of Cefiderocol by Reduced Dosing in Japanese Patients With Gram-Negative Bacterial Infections DOI
Naoya Itoh

Therapeutic Drug Monitoring, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Background: Recently, a cost-saving, dose-reducing strategy for cefiderocol against gram-negative bacteria with low minimum inhibitory concentrations (MICs) was proposed as an alternative to the standard dosing (ie, 2 g every 8 hours, 3-hours infusion). The objectives of this article are summarize available evidence on efficacy, safety, pharmacokinetics (PK), and pharmacodynamics support rationale approved assess any risk underexposure reduced doses 1 hours or 12 hours) regarding higher MICs. Methods: Published data from phase 1–3 clinical, preclinical effectiveness, surveillance studies were reviewed, new population PK simulations conducted. Results: Most carbapenem-resistant isolates displayed MICs up 4 mg/L. Single multiple cefiderocol, g, tested in clinical studies, which confirmed linear profile, metabolism, renal clearance, penetration into lungs soft tissues. Phase 2–3 randomized controlled have demonstrated efficacy safety at renally adjusted versus comparators patients complicated urinary tract infections, nosocomial pneumonia, bloodstream infection/sepsis caused by various carbapenem-susceptible -resistant pathogens. Population models incorporating predicted that regimen contrast doses, would achieve high probability target attainment isolates, 2–4 mg/L across infection types patient populations. Conclusions: Administering low-dose reduce treatment-related costs will lead treatment failure prolonged hospitalization incur further expenses. Therefore, is strongly recommended.

Language: Английский

Citations

0
Rescuing bacterial genome replication: essential functions to repair a double-strand break and restart DNA synthesis DOI
Charles Winterhalter, Stepan Fenyk, Heath Murray

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Abstract Many antibiotics indirectly generate reactive oxygen species (ROS) that can damage bacterial genomes. Oxidised nucleobases become genotoxic when they are targeted for repair through excision, generating a single-strand discontinuity be converted to double-strand break (DSB) by an oncoming replication fork. Because the genomic location of nucleobase oxidation is stochastic, investigating fate DNA machinery (replisome) at discontinuities has been limited. Here we have addressed this issue expressing Cas9 nickases in Bacillus subtilis create site specific chromosome. We find nicks either leading or lagging strand arrest fork progression and DSB requires using homologous recombination allow restart. These discoveries provoke reassessment fundamental mechanism provide insights development alternative antimicrobials identifying pathway potentiate ROS-dependent killing.

Language: Английский

Citations

0