Advances in Anthelmintic Target Identification DOI Open Access
Harrison T. Shanley, Tao Wang, Aya C. Taki

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3738 - 3738

Published: April 15, 2025

Parasitic nematodes pose a significant threat to human and animal health, causing widespread morbidity substantial socioeconomic losses globally. Despite the utility of anthelmintic drugs in parasite control, emergence resistance necessitates discovery novel interventions. Advances through use whole-organism phenotypic screening have identified some promising nematocidal compounds, including nemacol, tolfenpyrad, UMW-9729, ABX464. This article summarises efforts this discovery, with focus on Haemonchus contortus Caenorhabditis elegans as model nematodes, discusses approaches used for drug target deconvolution, proteomic, chemical genetic/genomic techniques. Stability-based proteomic assays, such thermal proteome profiling, been useful identifying protein targets these shedding light their mechanisms action. However, challenges remain extrapolating findings from C. parasitic emphasising need validation studies. Understanding drug–target interactions is critical developing next-generation anthelmintics mitigating growing challenge. review outlines recent progress area future directions development support control programmes.

Language: Английский

Advances in Anthelmintic Target Identification DOI Open Access
Harrison T. Shanley, Tao Wang, Aya C. Taki

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3738 - 3738

Published: April 15, 2025

Parasitic nematodes pose a significant threat to human and animal health, causing widespread morbidity substantial socioeconomic losses globally. Despite the utility of anthelmintic drugs in parasite control, emergence resistance necessitates discovery novel interventions. Advances through use whole-organism phenotypic screening have identified some promising nematocidal compounds, including nemacol, tolfenpyrad, UMW-9729, ABX464. This article summarises efforts this discovery, with focus on Haemonchus contortus Caenorhabditis elegans as model nematodes, discusses approaches used for drug target deconvolution, proteomic, chemical genetic/genomic techniques. Stability-based proteomic assays, such thermal proteome profiling, been useful identifying protein targets these shedding light their mechanisms action. However, challenges remain extrapolating findings from C. parasitic emphasising need validation studies. Understanding drug–target interactions is critical developing next-generation anthelmintics mitigating growing challenge. review outlines recent progress area future directions development support control programmes.

Language: Английский

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