Mini Review: Highlight of Recent Advances and Applications of MALDI Mass Spectrometry Imaging in 2024 DOI Open Access
Yuen T. Ngai, David C.W. Lau, Parul Mittal

et al.

Analytical Science Advances, Journal Year: 2025, Volume and Issue: 6(1)

Published: May 10, 2025

Abstract Matrix‐assisted laser desorption/ionisation mass spectrometry imaging (MALDI‐MSI) is an emerging tool that allows visualisation of hundreds analytes unbiasedly in a single experiment. This paper highlights the adaptations MALDI‐MSI different context 2024, such as clinical diagnostic, pharmacology, forensics applications, plant metabolism and biology. Challenges advancements were also discussed regarding sample preparation, instrumentations, data analysis, integration machine learning trend cell resolution multi‐omics. There are still rooms for improvements sensitivity, spatial resolution, acquisition algorithm across multi‐omics to enable at subcellular level.

Language: Английский

Mini Review: Highlight of Recent Advances and Applications of MALDI Mass Spectrometry Imaging in 2024 DOI Open Access
Yuen T. Ngai, David C.W. Lau, Parul Mittal

et al.

Analytical Science Advances, Journal Year: 2025, Volume and Issue: 6(1)

Published: May 10, 2025

Abstract Matrix‐assisted laser desorption/ionisation mass spectrometry imaging (MALDI‐MSI) is an emerging tool that allows visualisation of hundreds analytes unbiasedly in a single experiment. This paper highlights the adaptations MALDI‐MSI different context 2024, such as clinical diagnostic, pharmacology, forensics applications, plant metabolism and biology. Challenges advancements were also discussed regarding sample preparation, instrumentations, data analysis, integration machine learning trend cell resolution multi‐omics. There are still rooms for improvements sensitivity, spatial resolution, acquisition algorithm across multi‐omics to enable at subcellular level.

Language: Английский

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