Influence of polymer amphiphilicity on the cyclization efficiency of poly(2-oxazoline)s DOI Creative Commons
Nick Huettner, Hendrik Frisch, Tim R. Dargaville

et al.

European Polymer Journal, Journal Year: 2023, Volume and Issue: 203, P. 112659 - 112659

Published: Dec. 4, 2023

The steadily increasing interest in cyclic polymers has led to a plethora of proposed applications, particularly as biomaterials. However, the large-scale synthesis remains one greatest challenges field. One reason for this is poorly understood role polymer structure on cyclization efficiency, leading protocols that must be optimized case-by-case basis without consideration chemical nature polymer. Recently, we found through combination laboratory experiments and molecular dynamics simulations backbone flexibility major influence efficiency poly(cyclic imino ether)s. Concurrently, identified more flexible was also better solvated given organic solvent. To deconvolute importance solvation, study variety α-alkyne, ω-azide terminated (co)polymers 2-ethyl-2-oxazoline 2–n-butyl-2-oxazoline with different amphiphilicities, but same backbone, have been synthesized subjected copper-catalysed azide-alkyne cycloaddition (CuAAC) reactions water. In agreement our previous studies, it observed an increase chain hydrophobicity, hence decrease leads significant efficiency. further understand effect CuAAC reaction conditions outcome, concentrations temperatures were screened. This highlights amphiphilicity, generally aimed towards polymers.

Language: Английский

Macromolecular architectural effects on solution self-assembly of amphiphilic AB-type block copolymers DOI

Naoki Ozawa,

Tomoki Nishimura

Polymer Chemistry, Journal Year: 2024, Volume and Issue: 15(5), P. 349 - 370

Published: Jan. 1, 2024

This review discusses the self-assembly of amphiphilic linear and various non-linear polymers such as star cyclic architectures, highlighting how polymer architecture impacts behavior.

Language: Английский

Citations

11
Various Topological Poly(tert‐butyl acrylate)s and Their Impacts on Thermal and Solution Properties DOI Open Access

Suraj Aswale,

Hyerin Kang,

Aruna Kumar Mohanty

et al.

Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Abstract This study reports the synthesis of acrylate‐based polymers with diverse topologies, including cyclic and 8‐shaped structures, using a combination atom transfer radical polymerization (ATRP) click coupling reactions. The linear tetra‐arm poly( tert ‐butyl acrylate) (PtBA) similar molar masses are synthesized via activators regenerated by electron polymerization. These further transformed into respectively, through reaction. All topologies possessed mass confirmed 1 H NMR, FT‐IR, SEC, MALDI‐TOF spectrometry. influence macromolecular topology on intrinsic viscosity glass transition temperature ( T g ) is systematically investigated. findings show that within PtBA series, increases structural compactness, exhibiting higher than their precursors. Additionally, decreases as compactness across various topological macromolecules. observations highlight potential tool for fine‐tuning polymer properties, facilitating development advanced materials specific behaviors in solution bulk properties.

Language: Английский

Citations

0
Loop to linear: exploring the impact of corona topology on the properties of self-assembled polymer nanoparticles DOI
Haoxiang Zeng,

Markus Müllner

Polymer Chemistry, Journal Year: 2024, Volume and Issue: 15(16), P. 1648 - 1659

Published: Jan. 1, 2024

Cyclic block copolymers with photo-cleavable linkers were prepared, allowing looped-to-linear corona transformations via UV-induced post-assembly modification, and showcasing their versatility as topology-tuned drug delivery systems.

Language: Английский

Citations

1
Synthesis of Heterografted Amphiphilic Cyclic Polymers via the Self-Folding Cyclization Technique and Their Application as Oil-in-Water Emulsion Stabilizers DOI

Hao Zha,

Zuowei Wang, Lin Cheng

et al.

Macromolecules, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

Heterografted amphiphilic cyclic homopolymers were prepared by the self-folding cyclization technique. The reversible addition–fragmentation chain transfer (RAFT) polymerization of N,N′-disubstituted acrylamide with oligo(ethylene glycol) (OEG) and octyl groups (OEGOAM) was performed to afford linear POEGOAM two terminal anthryl groups. After in water, single-chain polymeric nanoparticles (SCPNs) produced from precursors via hydrophobic interaction. By irradiating aqueous solution SCPNs 365 nm UV light, heterografted polymers synthesized intramolecular coupling Due presence alkyl hydrophilic OEG side chains, both can be employed as emulsifiers stabilize oil-in-water emulsions. Compared emulsion stabilized POEGOAM, that using emulsifier exhibited higher long-term high-temperature stabilities. result could attributed more compact conformation compared polymers, which provide stability newly created oil–water interface. This work not only enriches monomer scope technique but also expands application fields well providing a novel insight for design efficient emulsifiers.

Language: Английский

Citations

1
A Facile Synthetic Approach to UV-Degradable Hydrogels DOI Open Access
Wan Li, Zhonghui Wang,

Le Jiang

et al.

Polymers, Journal Year: 2023, Volume and Issue: 15(18), P. 3762 - 3762

Published: Sept. 14, 2023

Light-degradable hydrogels have a wide range of application prospects in the field biomedicine. However, provision facile synthetic approach to light-degradable under mild conditions remains challenge for researchers. To surmount this challenge, UV-degradable is demonstrated manuscript. Initially, an crosslinker (UVDC) having o-nitrobenzyl ester groups was synthesized single step through employment Passerini three-component reaction (P-3CR). Both 1H NMR and MS spectra indicated successful synthesis high-purity UVDC, it experimentally that UVDC capable degradation 368 nm light. Furthermore, mixed with 8-arm PEG-thiol (sPEG20k-(SH)8) promptly yield hydrogel click reaction. The SEM image fabricated exhibits favorable crosslinking network hydrogel, proving hydrogel. After continuous irradiation, showed obvious gel-sol transition, which demonstrates possesses desirable property. In summary, by utilizing solely two-step devoid catalysts hazardous raw materials, can be obtained ambient conditions, greatly reduces difficulty synthesizing hydrogels. This work extends toolbox hydrogels, enabling their accelerated development.

Language: Английский

Citations

3
Topological transformation across different dimensions of supramolecular polymer via photo-isomerization DOI
Bin Mu, Liang Wang,

Zhongke Yang

et al.

Chemical Communications, Journal Year: 2023, Volume and Issue: 59(84), P. 12645 - 12648

Published: Jan. 1, 2023

The utilization of a complementary photo-isomerization monomer pair realizes dimension-based topological transformation the resulting supramolecular polymer.

Language: Английский

Citations

1
Investigations into the macrocyclization of poly(2-oxazoline)s and poly(2-oxazine)s DOI Creative Commons
Nick Huettner

Published: Jan. 1, 2024

This thesis takes a step towards the efficient synthesis of cyclic polymers, which have recently gained significant attention as potent materials in biomedical applications. Using biomedically-relevant poly(2-oxazoline)s and poly(2-oxazine)s, combination synthetic computational approaches identified importance so far overlooked polymer structure on cyclization reaction. Additionally, it was shown that control over oligomer formation during can be valuable tool to adjust material properties hydrogel systems, highlighting applicability not only pure polymers but also cyclic/oligomer mixtures.

Language: Английский

Citations

0
Fabrication of GSH‐Responsive Poly(Tertiary Amine‐Oxide)‐Based Nanomedicines for Enhanced Anticancer Drug Release DOI

Xianshuo Zhang,

Wei Ma, Peipei Wang

et al.

Macromolecular Chemistry and Physics, Journal Year: 2023, Volume and Issue: 225(4)

Published: Dec. 2, 2023

Abstract Poly(tertiary amine‐oxide)‐based polymeric nanocarriers have showed more functionalities than stealthy PEG‐based analogs due to the structure of phospholipid affinitive N ‐oxides groups, which has attracted considerable attention synthesis various zwitterionic copolymers with tertiary amine‐oxide grafts for enhanced anticancer drug delivery. However, poly(tertiary amphiphilic tumor intracellular microenvironment sensitivities, knowledge, been rarely reported likely lack a controlled synthetic strategy. Herein, reducible copolymer, poly( ε ‐caprolactone) 25 ‐SS‐poly(2‐( ‐oxide‐ , ‐diethylamino)ethyl methacrylate) 30 (PCL ‐SS‐OPDEA ) is designed and synthesized successfully via combination polymerization techniques post modification. Specifically, postoxidation amine) confirmed be better strategy toward well‐defined polymer relative direct ‐diethylaminoethyl methacrylate (ODEA). The effect disulfide bridges on self‐assembly behaviors, in vitro loading release properties investigated detail. Notablely, resulting micelles self‐assembled from PCL show much greater colloidal stability, higher content (DLC), cell inhibition reduction‐insensitive counterparts. Overall, this study reports robust nanomedicines on‐demand

Language: Английский

Citations

0
Influence of polymer amphiphilicity on the cyclization efficiency of poly(2-oxazoline)s DOI Creative Commons
Nick Huettner, Hendrik Frisch, Tim R. Dargaville

et al.

European Polymer Journal, Journal Year: 2023, Volume and Issue: 203, P. 112659 - 112659

Published: Dec. 4, 2023

The steadily increasing interest in cyclic polymers has led to a plethora of proposed applications, particularly as biomaterials. However, the large-scale synthesis remains one greatest challenges field. One reason for this is poorly understood role polymer structure on cyclization efficiency, leading protocols that must be optimized case-by-case basis without consideration chemical nature polymer. Recently, we found through combination laboratory experiments and molecular dynamics simulations backbone flexibility major influence efficiency poly(cyclic imino ether)s. Concurrently, identified more flexible was also better solvated given organic solvent. To deconvolute importance solvation, study variety α-alkyne, ω-azide terminated (co)polymers 2-ethyl-2-oxazoline 2–n-butyl-2-oxazoline with different amphiphilicities, but same backbone, have been synthesized subjected copper-catalysed azide-alkyne cycloaddition (CuAAC) reactions water. In agreement our previous studies, it observed an increase chain hydrophobicity, hence decrease leads significant efficiency. further understand effect CuAAC reaction conditions outcome, concentrations temperatures were screened. This highlights amphiphilicity, generally aimed towards polymers.

Language: Английский

Citations

0