Multifunctional nanoplatforms based on RNA interference for glioma treatment DOI
Ting Zhao, Hongping Ju, Zihao Chen

et al.

American Journal of Cancer Research, Journal Year: 2025, Volume and Issue: 15(3), P. 835 - 854

Published: Jan. 1, 2025

Glioma is the most common malignant tumor in central nervous system. Currently, clinical treatments for glioma include surgery, radiation therapy, chemotherapy and immunotherapy, among which combination of immunotherapy has attracted wide attention. However, ability chemotherapeutic agents immune checkpoint blockers to reach gliomas limited due existence blood brain/tumor barrier (BBB/BTB). RNA interference (RNAi) technology enables specific silencing target genes associated with cancer so it been used as an emerging potential treatment strategy. Small (siRNA) easily degraded by serum endonuclease, can be quickly filtered cleared glomerulus. Therefore, design construction safe effective delivery systems conducive improving stability siRNA efficiency gene silencing. This review focuses on research progress nano system based treatment.

Language: Английский

Targeted delivery systems of siRNA based on ionizable lipid nanoparticles and cationic polymer vectors DOI
Zhao Yao,

Taiqing Liu,

Jingwen Wang

et al.

Biotechnology Advances, Journal Year: 2025, Volume and Issue: 81, P. 108546 - 108546

Published: Feb. 26, 2025

Language: Английский

Citations

2
Multifunctional nanoplatforms based on RNA interference for glioma treatment DOI
Ting Zhao, Hongping Ju, Zihao Chen

et al.

American Journal of Cancer Research, Journal Year: 2025, Volume and Issue: 15(3), P. 835 - 854

Published: Jan. 1, 2025

Glioma is the most common malignant tumor in central nervous system. Currently, clinical treatments for glioma include surgery, radiation therapy, chemotherapy and immunotherapy, among which combination of immunotherapy has attracted wide attention. However, ability chemotherapeutic agents immune checkpoint blockers to reach gliomas limited due existence blood brain/tumor barrier (BBB/BTB). RNA interference (RNAi) technology enables specific silencing target genes associated with cancer so it been used as an emerging potential treatment strategy. Small (siRNA) easily degraded by serum endonuclease, can be quickly filtered cleared glomerulus. Therefore, design construction safe effective delivery systems conducive improving stability siRNA efficiency gene silencing. This review focuses on research progress nano system based treatment.

Language: Английский

Citations

0