Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
15(2), P. 834 - 851
Published: Nov. 25, 2024
The
size
of
nanodrugs
plays
a
crucial
role
in
shaping
their
chemical
and
physical
characteristics,
consequently
influencing
therapeutic
diagnostic
interactions
within
biological
systems.
optimal
nanomedicines,
whether
small
or
large,
offers
distinct
advantages
disease
treatment,
creating
dilemma
the
selection
process.
Addressing
this
challenge,
size-transformable
have
surfaced
as
promising
solution,
they
can
be
tailored
to
entail
benefits
associated
with
both
large
nanoparticles.
In
review,
various
strategies
are
summarized
for
constructing
nanosystems
focus
on
nanotherapeutic
applications
field
biomedicine.
Particularly
we
highlight
recent
research
developments
cancer
therapy.
This
review
aims
inspire
researchers
further
develop
toolboxes
fabricating
nanomedicines
improved
intervention
against
diverse
human
diseases.
Materials & Design,
Journal Year:
2024,
Volume and Issue:
241, P. 112893 - 112893
Published: April 1, 2024
Insufficient
drug
accumulation
at
tumor
sites
is
one
of
the
key
factors
leading
to
treatment
failure
in
breast
cancer
(BC),
and
developing
a
chemotherapeutic
delivery
system
that
can
improve
immune
microenvironment
expand
benefits
immunochemotherapy
for
BC
remains
challenge.
To
increase
efficacy
by
extending
retention
site,
we
developed
pH-responsive
peptide
modified
with
PHSCN
sequence
(Pep1)
self-assembles
form
spherical
DM/Pep1
nanoparticles
after
encapsulating
doxorubicin
(DOX)
metformin
(MET).
In
acidic
microenvironment,
nanocarriers
transform
into
aggregates
high
aspect
ratio,
facilitating
DOX
MET
release
combined
chemotherapy
immunomodulation.
cellular
experiments,
this
construct
provided
prolonged
cells.
subcutaneous
mouse
model,
exhibited
superior
inhibition
effect
compared
free
DOX/MET.
The
nanocomplex
upregulated
CD4,
induced
calreticulin
(CRT)
exposure,
downregulated
PD-L1,
enhanced
MET-mediated
antitumor
response.
use
nanocarrier
morphological
transformation
offers
promising
strategy
therapy.
Materials & Design,
Journal Year:
2024,
Volume and Issue:
241, P. 112911 - 112911
Published: April 2, 2024
Traditional
cancer
treatment
modalities
such
as
surgery,
chemotherapy,
and
radiation
therapy
have
seen
significant
advancements
in
the
past.
However,
inherent
drawbacks,
including
systemic
toxicity
high
recurrence
rates.
Consequently,
The
nanoparticles,
with
their
targeting
multifunctionality,
captured
attention.
This
work
synthesizes
HMNPs-C60-N-GQDs-SS-PEI
(HMNPs:Fe3O4@SiO2@mSiO2-C18)
integrating
diverse
functionalities
for
enhanced
therapy.
inclusion
of
SiO2
C60
significantly
improves
loading
efficiency
gallic
acid
(GA).
magnetic
properties
HMNPs
enable
efficient
to
sites
under
external
fields.
-SS-
linkage
ensures
drug
release
exclusively
tumor
cells
over-expressing
glutathione
(GSH),
minimizing
adverse
effects
on
normal
tissues.
Introduction
Polyethyleneimine
(PEI)
imparts
positive
charge
facilitate
accumulation
negatively
charged
surfaces
enhances
biocompatibility.
Additionally,
fluorescence
N-doped
graphene
quantum
dots
(N-GQDs)
real-time
monitoring
material
distribution
vivo
during
mouse
clinical
Furthermore,
nano-magnetic
demonstrates
precise
control
over
release,
addressing
issues
poor
biocompatibility
biotoxicity
associated
traditional
materials.
study
not
only
achieves
effective
but
also
offers
a
promising
direction
developing
multifunctional
nano-targeting
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(17), P. 20609 - 20625
Published: Aug. 29, 2024
Hepatocellular
carcinoma
(HCC)
is
a
challenging
cancer
to
treat
due
its
high
malignancy,
strong
invasiveness,
and
risk
of
metastasis.
Inhibiting
lymphatic
metastasis
in
the
early
stages
crucial
for
HCC
therapy.
Active
targeted
drug
delivery
systems,
imbued
with
tumor
targeting
capability
via
ligand–receptor
mediation,
represent
promising
therapeutic
strategy.
Cantharidin
(CTD),
primary
effective
component
poisonous
traditional
Chinese
medicine
(PTCM)
Mylabris,
has
unique
effects
on
HCC.
However,
toxicity
limits
clinical
application.
In
this
study,
based
expression
vessel
endothelial
hyaluronan
receptor-1
(LYVE-1)
peritumoral
vessels
glycyrrhetinic
acid
receptor
(GA-R)
hepatocellular
cells,
we
developed
CTD-loaded
poly(d,l-lactide-co-glycolide)
(PLGA)
nanoparticles
modified
(GA)–hyaluronic
(HA)
copolymers
(GA-HA-PLGA/CTD
NPs)
through
electrostatic
interactions.
This
nanoparticle
platform
could
preferentially
accumulate
cargo
into
tumors
vessels,
increasing
accumulation
lymph
nodes
while
decreasing
other
organs,
particularly
heart
kidney.
As
result,
it
enhance
antitumor
efficacy
inhibit
better
than
PLGA/CTD
NPs
also
reducing
systemic
toxicity.
Furthermore,
variation
HA
molecular
weights
degrees
GA
substitution
regulate
distribution
within
nodes.
Overall,
GA-HA-PLGA/CTD
exhibit
potential
as
approach
treatment
inhibition,
providing
strategy
application
PTCMs
treatment.
Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
15(2), P. 834 - 851
Published: Nov. 25, 2024
The
size
of
nanodrugs
plays
a
crucial
role
in
shaping
their
chemical
and
physical
characteristics,
consequently
influencing
therapeutic
diagnostic
interactions
within
biological
systems.
optimal
nanomedicines,
whether
small
or
large,
offers
distinct
advantages
disease
treatment,
creating
dilemma
the
selection
process.
Addressing
this
challenge,
size-transformable
have
surfaced
as
promising
solution,
they
can
be
tailored
to
entail
benefits
associated
with
both
large
nanoparticles.
In
review,
various
strategies
are
summarized
for
constructing
nanosystems
focus
on
nanotherapeutic
applications
field
biomedicine.
Particularly
we
highlight
recent
research
developments
cancer
therapy.
This
review
aims
inspire
researchers
further
develop
toolboxes
fabricating
nanomedicines
improved
intervention
against
diverse
human
diseases.
