Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 378, P. 247 - 249
Published: Dec. 14, 2024
Language: Английский
Nanotechnology, Journal Year: 2024, Volume and Issue: 35(13), P. 132001 - 132001
Published: Jan. 10, 2024
Abstract Chemotherapy is an important cancer treatment modality, but the clinical utility of chemotherapeutics limited by their toxic side effects, inadequate distribution and insufficient intracellular concentrations. Nanodrug delivery systems (NDDSs) have shown significant advantages in diagnosis treatment. Variable NDDSs that respond to endogenous exogenous triggers attracted much research interest. Here, we summarized nanomaterials commonly used for tumor therapy, such as peptides, liposomes, carbon nanotubes, well responses pH, enzymes, magnetic fields, light, multiple stimuli. Specifically, well-designed can change size or morphology rupture when induced one more The varying stimulation contribute molecular design development novel NDDSs, providing new ideas improving drug penetration accumulation, inhibiting resistance metastasis, enhancing immunotherapy.
Language: Английский
Citations
9
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 68 - 68
Published: Jan. 6, 2025
Nanoparticle-based drug delivery systems hold great promise for improving the effectiveness of anti-tumor therapies. However, their clinical translation remains hindered by several significant challenges, including intricate preparation processes, limited loading capacity, and concerns regarding potential toxicity. In this context, pure drug-assembled nanosystems (PDANSs) have emerged as a promising alternative, attracting extensive research interest due to simple methods, high efficiency, suitability large-scale industrial production. This innovative approach presents new opportunities enhance both safety therapeutic efficacy cancer treatments. review comprehensively explores recent progress in application PDANSs therapy. It begins detailing self-assembly mechanisms fundamental principles underlying PDANS formation. The discussion then advances strategies assembling single nanoparticles, well co-assembly multiple drugs. Subsequently, addresses combination treatment modalities, encompassing diagnostic applications. These include combinations chemotherapeutic agents, phototherapeutic approaches, integration chemotherapy with phototherapy, synergistic use immunotherapy other methods. Finally, highlights advancing tumor therapy prospects application, providing key insights future aimed at optimizing technology broadening its utility treatment.
Language: Английский
Citations
1
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(18)
Published: April 8, 2024
Increasing the penetration and accumulation of antitumor drugs at tumor site are crucial in chemotherapy. Smaller drug-loaded nanoparticles (NPs) typically exhibit increased more effective permeation through nuclear membrane, whereas larger NPs show extended retention site. In addition, cancer stem cells (CSCs) have unlimited proliferative potential for onset, progression, metastasis cancer. Therefore, a amphiphilic peptide, DDP- ATRA-loaded Pep1 (DA/Pep1), is designed that self-assembles into spherical upon encapsulation cis-diamminedichloroplatinum (DDP) all-trans retinoic acid (ATRA). an acidic environment, DA/Pep1 transforms aggregates containing sheet-like structures, which significantly increases drug site, thereby increasing effects inhibiting metastasis. Moreover, although DDP treatment can increase number CSCs present, ATRA induce differentiation breast to therapeutic effect DDP. conclusion, this peptide nanodelivery system response microenvironment extremely promising nanoplatform suggests new idea combined tumors.
Language: Английский
Citations
7
Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(19), P. 4855 - 4874
Published: Jan. 1, 2024
In recent years, supramolecular hydrogels have made groundbreaking research progress in biomedical fields such as drug delivery, biosensing, imaging analysis, and tissue engineering. Peptides, with their unique characteristics of facile preparation, low immunogenicity easy biodegradability, are commonly used building blocks hydrogels. Peptide-based loaded drugs, prepared
Language: Английский
Citations
7
Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2025, Volume and Issue: unknown, P. 136848 - 136848
Published: April 1, 2025
Language: Английский
Citations
0
Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101821 - 101821
Published: April 1, 2025
Language: Английский
Citations
0
Biomaterials Advances, Journal Year: 2024, Volume and Issue: 160, P. 213852 - 213852
Published: April 16, 2024
Language: Английский
Citations
2
Current Pharmaceutical Design, Journal Year: 2024, Volume and Issue: 30(15), P. 1136 - 1148
Published: March 29, 2024
Tumor metastasis is a complex process that controlled at the molecular level by numerous cytokines. Primary breast and prostate tumors most commonly metastasize to bone, development of increasingly accurate targeted nanocarrier systems has become research focus for more effective anti-bone therapy. This review summarizes mechanisms bone principles methods designing bone-targeted nanocarriers then provides an in-depth treatment in context chemotherapy, photothermal therapy, gene combination Furthermore, this also discusses metastatic primary tumors, providing directions design nanodelivery future research.
Language: Английский
Citations
1
Materials & Design, Journal Year: 2023, Volume and Issue: 238, P. 112619 - 112619
Published: Dec. 31, 2023
Chemotherapeutic drugs have low aggregation rates and short retention times in tumors, severely limiting their clinical application. Additionally, the development spread of solid tumors is highly dependent on neovascularization. An RGD-modified acid-responsive peptide was designed to encapsulate chemotherapeutic drug paclitaxel (PTX) antiangiogenic sorafenib (SF), enabling them self-assemble into nanoparticles (NPs) a physiological environment. In an acidic environment, release PTX SF achieved when drug-loaded experimental PS/Pep1 transformed from spherical NPs aggregates containing nanofibers, which effectively prolonged encapsulated increased accumulation. Furthermore, both vivo ex experiments provided compelling evidence strong inhibitory effects tumor growth metastasis, as well its effective suppression angiogenesis. This targeted NP system that undergoes morphological shift microenvironment holds promise for enhancing efficacy combined administration inhibit metastasis.
Language: Английский
Citations
3
Materials & Design, Journal Year: 2024, Volume and Issue: 241, P. 112893 - 112893
Published: April 1, 2024
Insufficient drug accumulation at tumor sites is one of the key factors leading to treatment failure in breast cancer (BC), and developing a chemotherapeutic delivery system that can improve immune microenvironment expand benefits immunochemotherapy for BC remains challenge. To increase efficacy by extending retention site, we developed pH-responsive peptide modified with PHSCN sequence (Pep1) self-assembles form spherical DM/Pep1 nanoparticles after encapsulating doxorubicin (DOX) metformin (MET). In acidic microenvironment, nanocarriers transform into aggregates high aspect ratio, facilitating DOX MET release combined chemotherapy immunomodulation. cellular experiments, this construct provided prolonged cells. subcutaneous mouse model, exhibited superior inhibition effect compared free DOX/MET. The nanocomplex upregulated CD4, induced calreticulin (CRT) exposure, downregulated PD-L1, enhanced MET-mediated antitumor response. use nanocarrier morphological transformation offers promising strategy therapy.
Language: Английский
Citations
0