Macrophage Polarization-Based Biomaterials for Repairing Spinal Cord Injury DOI
Junchao Luo, Wei Hu, Xiang Gao

et al.

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(12), P. 5438 - 5453

Published: Nov. 16, 2024

Spinal cord injury (SCI) remains a serious problem, owing to its severe consequences and therapeutic limitations. It leads irreversible impairment of both motor sensory functions, posing challenge recovery imposing an immense socioeconomic burden on patients. Existing treatment strategies for SCI primarily focus secondary injury, particularly the modulation immune microenvironment after SCI. Infiltrating macrophages play crucial role in regulating inflammation around site. Macrophages alter their functional phenotypes response various stimuli. Classically activated (M1) exacerbate pro-inflammatory function, whereas alternatively (M2) inhibit inflammatory response. Therefore, macrophage polarization represents promising strategy Several biomaterial-based repairing have been developed are constantly being updated with technological advancements ability alleviate neuroinflammation promote neuroregeneration. In this Review, we discuss recent research progress biomaterials targeting macrophage-mediated repair regeneration following Altogether, Review provides novel insights into

Language: Английский

Multifunctional MXene-Based Hydrogel Remodels Regenerative Microenvironment and Facilitates Neurogenesis of Endogenous Neural Stem Cells for Spinal Cord Injury Recovery DOI
P. L. Zhu, Lu Ge,

Tong Luo

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Language: Английский

Citations

0
Macrophage Polarization-Based Biomaterials for Repairing Spinal Cord Injury DOI
Junchao Luo, Wei Hu, Xiang Gao

et al.

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(12), P. 5438 - 5453

Published: Nov. 16, 2024

Spinal cord injury (SCI) remains a serious problem, owing to its severe consequences and therapeutic limitations. It leads irreversible impairment of both motor sensory functions, posing challenge recovery imposing an immense socioeconomic burden on patients. Existing treatment strategies for SCI primarily focus secondary injury, particularly the modulation immune microenvironment after SCI. Infiltrating macrophages play crucial role in regulating inflammation around site. Macrophages alter their functional phenotypes response various stimuli. Classically activated (M1) exacerbate pro-inflammatory function, whereas alternatively (M2) inhibit inflammatory response. Therefore, macrophage polarization represents promising strategy Several biomaterial-based repairing have been developed are constantly being updated with technological advancements ability alleviate neuroinflammation promote neuroregeneration. In this Review, we discuss recent research progress biomaterials targeting macrophage-mediated repair regeneration following Altogether, Review provides novel insights into

Language: Английский

Citations

0