Bi‐Pt Heterojunction Cascade Reaction Platform for Sono‐Immunotherapy of Tumors via PANoptosis and Ferroptosis

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 5, 2024

Abstract Sonodynamic therapy (SDT) represents a promising, noninvasive, and precise treatment modality for tumors, demonstrating significant potential in clinical applications. However, the efficiency of sonosensitizers generating reactive oxygen species (ROS) is often limited by rapid electron‐hole recombination. In this study, BiF 3 @BiOI synthesized via co‐precipitation method, followed in‐situ reduction to decorate it with Pt nanoparticles, resulting @BiOI@Pt‐PVP (BBP) nanocomposite enhancing SDT efficacy. The formation heterojunction enhances charge separation ability. decoration nanoparticles narrows bandgap alters band positions Fermi level BBP, which can effectively mitigate recombination pairs facilitate cascade reaction ROS, thereby improving ROS generation ultrasound excitation. Additionally, bismuth ions BBP generated holes consume glutathione, exacerbating cellular oxidative damage, triggering PANoptosis ferroptosis. Furthermore, demonstrate peroxidase‐like activity, catalyzing endogenous hydrogen peroxide oxygen. These functions are helpful against tumors alleviating hypoxic conditions, reshaping microenvironment, modulating immune cell infiltration capacity, efficacy immunotherapy. dual strategy forming heterojunctions sensitization noble metals sono‐catalytic therapy‐induced activation tumor treatment.

Language: Английский

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Supramolecular Nanozymes Based on Self-Assembly of Biomolecule for Cancer Therapy

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2043 - 2057

Published: Feb. 1, 2025

Natural enzyme systems possess extraordinary functions and characteristics, making them highly appealing for use in eco-friendly technologies innovative cancer treatments. However, their inherent instability structural complexity often limit practical applications, leading to the exploration of biomolecular nanozyme alternatives. Supramolecular nanozymes, constructed using self-assembly techniques various non-covalent interactions, have emerged as a promising solution. Amino acids, peptides, protein motifs offer flexible building blocks constructing these nanozymes. Importantly, well-defined regulation mechanisms along with unique properties fundamental biological modules living systems-such selectivity, permeability, retention, biocompatibility-present new opportunities therapy. This review highlights recent advances supramolecular self-assembled including peroxidases, oxidases, catalases, superoxide dismutases, other systems, tumor Additionally, it discusses precise functional modulation through interactions therapeutic applications targeting microenvironment. These studies provide valuable insights that may inspire design novel nanozymes enhanced catalytic biocompatibility, tumor-killing efficacy.

Language: Английский

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Unbiasedly decoding the tumor microenvironment with single-cell multiomics analysis in pancreatic cancer

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: July 9, 2024

Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with poor prognosis and limited therapeutic options. Research on the tumor microenvironment (TME) of PDAC has propelled development immunotherapeutic targeted strategies promising future. The emergence single-cell sequencing mass spectrometry technologies, coupled spatial omics, collectively revealed heterogeneity TME from multiomics perspective, outlined trajectories cell lineages, important functions previously underrated myeloid cells stroma cells. Concurrently, these findings necessitated more refined annotations biological at cluster or level. Precise identification all clusters urgently needed to determine whether they have been investigated adequately identify target antitumor potential, design compatible treatment strategies, resistance. Here, we summarize recent research level, an unbiased focus potential classification bases every cellular component within TME, look forward prospects integrating data retrospectively reusing bulk data, hoping provide new insights into TME.

Language: Английский

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Paclitaxel Prodrug Enables Glutathione Depletion to Boost Cancer Treatment

ACS Nano, Journal Year: 2024, Volume and Issue: 18(39), P. 26690 - 26703

Published: Sept. 20, 2024

Herein, we constructed a paclitaxel (PTX) prodrug (PA) by conjugating PTX with acrylic acid as cysteine-depleting agent. The as-synthesized PA can assemble diacylphosphatidylethanolamine-PEG

Language: Английский

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Inorganic Nanobiomaterials Boost Tumor Immunotherapy: Strategies and Applications

Accounts of Chemical Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

ConspectusTumor immunotherapy, as a new antitumor method to fight cancer by activating or enhancing the body's own immune system, has been extensively studied and applied in clinical practice. However, an extremely complex tumor heterogeneity immunosuppressive microenvironment (TME) lead poor response rate secondary drug resistance. The advent of nanotechnology ushered era for immunotherapy. In particular, inorganic nanomaterials, with their unique physicochemical properties excellent biocompatibility, are becoming important tool Inorganic nanomaterials can be used carriers agents, improving delivery efficiency thereby reducing systemic immunotoxicity responses. also trigger immunogenic cell death (ICD), stimulate responses, alleviate TME increasing oxygen levels, modulating metabolic pathways, altering secretion cytokines. synergistic integration immunotherapy adeptly navigates around constraints conventional treatments, side effects while concurrently augmenting therapeutic efficacy. this review, we summarize our recent efforts design synthesis nanobiomaterials enhance efficacy These achieve desired mainly through four strategies, including inducing ICD, developing nanovaccines, pyroptosis, regulating metabolism, providing beneficial implications For one thing, due deficiency ICD effect single therapy, developed nanocatalysts that integrate multiple functions play catalytic role TME, converting substances metabolites into products situ, further ICD. another, order solve problems low antigen loading existing adjuvants, several novel multifunctional nanoadjuvants were prepared, which combine high multimode function one, efficient activation. Moreover, attain strong inflammatory responses immunogenicity, engineer pyroptosis adjuvants selectively induce intracellular oxidative stress ion overload. Finally, reverse microenvironment, nanoplatforms target levels nutrients such glucose, lactic acid, citric tryptophan effectively alter response. implementation these strategies not only improves but reduces provides valuable insights references development assist

Language: Английский

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Inducing Pyroptosis and Cuproptosis Using Copper Carriers for ROS-Augmented Effective Cancer Therapy

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(9), P. 4282 - 4290

Published: Aug. 20, 2024

Copper overload shows promise as a therapeutic strategy by disrupting copper homeostasis and inducing cell death pathways. However, challenges include the expulsion of excess from cells. This study introduces ZCCP NPs, three-metal MOF nanoparticles that amplify reactive oxygen species (ROS) to enhance cellular uptake reduce efflux. In tumor microenvironment, NPs decompose in response H+ glutathione (GSH), releasing Zn Co ions increase intracellular ROS. Additionally, TMPyP ligand converts Phlorin under near-infrared (NIR) excitation, raising site temperature increasing cancer susceptibility cuproptosis. Elevated ROS activate NLRP3 inflammasome Caspase-1, leading gasdermin D cleavage pyroptosis. Enhanced generation impairs mitochondrial function reduces efflux protein ATP7A expression, promoting combines pyroptosis cuproptosis for effective treatment.

Language: Английский

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Dynamic polyphenol nanoparticles boost cuproptosis-driven metalloimmunotherapy of breast cancer

Nano Today, Journal Year: 2024, Volume and Issue: 58, P. 102442 - 102442

Published: Aug. 17, 2024

Language: Английский

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Engineering of a Low Intrinsic Fluorescence and Chemical-Stable Fluorescent Probe Enables Highly Sensitive Detection of Biothiols and High-Fidelity Imaging of Dihydroartemisinin-Induced Ferroptosis

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 424, P. 136913 - 136913

Published: Nov. 8, 2024

Language: Английский

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Nanomaterials evoke pyroptosis boosting cancer immunotherapy

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 15(2), P. 852 - 875

Published: Nov. 23, 2024

Cancer immunotherapy is currently a very promising therapeutic strategy for treating tumors. However, its effectiveness restricted by insufficient antigenicity and an immunosuppressive tumor microenvironment (ITME). Pyroptosis, unique form of programmed cell death (PCD), causes cells to swell rupture, releasing pro-inflammatory factors that can enhance immunogenicity remodel the ITME. Nanomaterials, with their distinct advantages different techniques, are increasingly popular, nanomaterial-based delivery systems demonstrate significant potential potentiate, enable, augment pyroptosis. This review summarizes discusses emerging field nanomaterials-induced pyroptosis, focusing on mechanisms pyroptosis pathways strategies activate or specific Additionally, we provide perspectives development this field, aiming accelerate further clinical transition.

Language: Английский

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