Current Status and Perspectives of Research on Polymer Hydrogels in the Treatment and Protection of Osteoarthritis

Macromolecular Bioscience, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract Arthritis is a degenerative disease characterized by chronic cartilage degeneration. It affects hundreds of millions people worldwide and often has serious consequences such as joint pain swelling, limited mobility, deformity. However, conventional treatments still struggle to achieve satisfactory results. Finding more effective for arthritis remains an important clinical challenge. As hydrogels have unique 3D spatial mesh structure, significant material interaction ability, adjustable mechanical properties, good biodegradability, they can provide suitable cellular or tissue microenvironment, their potential in scaffolding effect, lubrication, anti‐inflammatory drug delivery expected be potent therapeutic approach the treatment osteoarthritis. In this review, three aspects hydrogel products osteoarthritis are comprehensively summarized discussed, namely, selection gel design, exploration cross‐linking mechanisms, mechanisms therapy osteoarthritis, focus on advantages limitations applications, which point out direction development strategy innovative field, applied research, transformation.

Language: Английский

Bioactive Matters based on Natural Product for Cardiovascular Diseases

Smart Materials in Medicine, Journal Year: 2024, Volume and Issue: 5(4), P. 542 - 565

Published: Nov. 16, 2024

Language: Английский

Robust, notch-insensitive and impact-resistance physical hydrogels with homogeneous topologic network enabled by partial hydrolysis and metal coordination

Polymer, Journal Year: 2024, Volume and Issue: 317, P. 127913 - 127913

Published: Dec. 9, 2024

Language: Английский