Published: Jan. 1, 2025
Language: Английский
Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 26, 2025
The integration of photodynamic therapy (PDT) and photothermal (PTT) offers a promising strategy for enhancing phototherapy efficiency. Herein, we present dual-functional, biocompatible nanocomposite system combination PDT/PTT therapy. utilizes highly nanoparticle assembled by an amphiphilic short peptide with the assistance Zn2+ as carrier. convertor is loaded within nanoparticle, while cationic porphyrin photosensitizer on surface. water-soluble (M8PzEOPP), designed eight positive charges, provides strong electrostatic interaction stable assembly This location-independent effectively maintains optical characteristics both convertor, endowing effective properties. exhibits excellent tumor-targeting accumulation behavior, low dark toxicity, robust extracellular biostability, high cell internalization Its enhanced performance in combinatorial demonstrated through vitro vivo experiments.
Language: Английский
Citations
1
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: May 19, 2025
Abstract Bacterial infections in burn and scald wounds seriously endanger patients. Effectively eliminating bacteria regulating wound exudate are crucial for preventing reducing mortality. This study introduces a nitric oxide (NO)‐releasing antibacterial poly(ionic liquid)/carbon nitride (C 3 N 4 )‐based Janus fibrous membrane (PIL‐C ). The PIL‐C is constructed as double‐layer membrane, comprising hydrophilic layer hydrophobic that contains L‐arginine‐functionalized C , which serves light‐stimuli‐responsive NO donor. structure of facilitates unidirectional transport regulation microenvironment. Upon exposure to light, demonstrates simultaneous controlled release NO, effectively through the synergistic therapeutic effects PIL. In vivo studies indicate significantly reduces bacterial viability alleviates inflammation promotes collagen deposition, thereby enhancing healing wounds. research may contribute development innovative platforms management treatment bacteria‐infected
Language: Английский
Citations
1
International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2743 - 2759
Published: March 1, 2025
Photodynamic therapy (PDT) is a promising strategy with significant clinical application potential for tumor treatment. However, the hypoxia and limited efficacy against metastasis present limitations in of PDT. To alleviate PDT growth metastasis, we developed self-oxygenated immunoliposome by encapsulating catalase (CAT) within liposome cavity loading photosensitizer chlorin e6 (Ce6) immunoadjuvant MPLA lipid bilayer (CAT@LP-Ce6-A). Subsequently, fused it cancer cell membrane (CCM) to create hybrid (CAT@LP-CCM-Ce6-A). The vitro vivo anti-cancer CAT@LP-CCM-Ce6-A-based photodynamic immunotherapy (PDIT) was evaluated. CAT@LP-CCM-Ce6-A were characterized size, zeta potential, transmission electron microscopy (TEM), Coomassie bright blue staining, UV spectrophotometer, standard Goth's method. Cellular uptake, viability, reactive oxygen species (1O2) generation, calreticulin exposure, ability promote BMDCs maturation evaluated vitro. Biodistribution, therapeutic efficacy, safety investigated orthotopic triple-negative breast (TNBC) lung mouse models. successfully via thin film hydration co-extrusion capacity Ce6 CAT 4.7 ± 0.9% 8.5 respectively. exhibited improved cellular uptake efficiency cytotoxicity under laser irradiation TNBC. Furthermore, possessed enhanced anti-enzymatic degradation promotion DC maturation. In TNBC-bearing mice, PDIT demonstrated remarkable effect antitumor immunity while maintaining minimal systemic toxicity. could be employed as an innovative approach cancer.
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0