Therapeutic Potential of Microneedle Assisted Drug Delivery for Wound Healing: Current State of the Art, Challenges, and Future Perspective

AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 8, 2025

Language: Английский

---

Implantable Microneedles Loaded with Nanoparticles Surface Engineered Escherichia coli for Efficient Eradication of Triple-Negative Breast Cancer Stem Cells

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Eliminating cancer stem cells (CSCs) is essential for the effective treatment of triple-negative breast (TNBC). This study synthesized Au@cerium-zinc composite core@shell nanoparticles (Au@Zn/CeO) that were subsequently conjugated with Escherichia coli (E. coli) to create engineered bacterium AZCE, which was then combined microneedle carriers and freeze-dried obtain AZCE-MN. Upon implantation into TNBC tumors, inherent properties E. facilitate AZCE penetrate extracellular matrix break through basement membrane, enabling delivery AZC CSCs-enriched regions deep within tumor. The released Zn2+ induces mitochondrial dysfunction amplifies reactive oxygen species (ROS) production. redox cycling between Ce3+/Ce4+ effectively depleted glutathione, further increased ROS generation. Under near-infrared laser irradiation, Au nanorods initiated photothermal therapy, ablating CSCs while amplifying catalytic reactions ionic effects. microneedle-mediated bacteria improved nanodrug penetration in tumor tissues, providing new insights clinical treatment.

Language: Английский

---

“Monitor-and-treat” that integrates bacterio-therapeutics and bio-optics for infected wound management

Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 118 - 134

Published: Feb. 15, 2025

Language: Английский

---

Fabrication of Zinc-Tryptophan Nanoassemblies for Antibacterial and Wound Healing Applications

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Language: Английский

---

Research Progress on Antibacterial Applications of Bioactive Materials in Wound Infections: Design, Challenges, and Prospects

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Bacterial wound infections pose a significant threat to global health, exacerbated by the increase in multidrug-resistant bacteria (MDRB) and formation of elastic biofilms. This review explores transformative potential bioactive materials addressing these challenges, focusing on their design, mechanisms action, therapeutic effects. In vivo, are designed respond unique bacterial microenvironment (BME), utilizing enzyme activity, controlled gas release, surface functionalization, immune regulation combat infections. vitro, this provides comprehensive overview latest advances rational design materials, emphasizing synergistic integration structural modifications (such as size morphology) with external physical stimuli light, sound, electricity, magnetism, force) enhance antibacterial performance. Finally, outstanding challenges prospects rapidly evolving field discussed.

Language: Английский

---

Leveraging Nanoengineered Microneedle‐Augmented Drug Delivery in Oncological Intervention

Particle & Particle Systems Characterization, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 25, 2024

Abstract The landscape of chemotherapy for cancer is experiencing a dramatic transition with the integration sophisticated drug delivery methods, especially nanoengineered microneedles. Percutaneous vaccination regarded optimum therapeutic approach due to high amount immune cell accumulation and rich capillary lymphatic system in dermis. curative impact Microneedles‐based vaccines suboptimal complicated mix tumor, host, environmental variables, as well vaccine's restricted loading capacity. As result, additional enhancements are still needed accelerate their clinical translation. This article offers meticulous analysis avant‐garde strategies harnessed augment via microneedle. Various tactics, such tailored nanoparticle carriers, functionalized microneedle arrays, real‐time monitoring system, work together improve efficacy prevent off‐target effects. By integrating recent advancement delineating future trajectories, this gives an in‐depth how microneedle‐augmented technologies have potential change face therapy, heralding new era precision medicine better outcomes.

Language: Английский

---

An Electrochemical Method for the Direct Sulfonylation of N‐(4‐hydroxyphenyl)‐sulfonamides with Sulfonyl Hydrazides

European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 28(5)

Published: Dec. 23, 2024

Abstract A facile electrochemical strategy for the synthesis of sulfonylphenol derivatives from N ‐(4‐hydroxyphenyl)‐sulfonamides with sulfonyl hydrazides has been successfully developed. This metal‐ and oxidant‐free protocol is suitable aromatic, heteroaromatic aliphatic reagents to afford corresponding sulfonylated products in moderate high yields under mild conditions. gram‐scale experiment an vitro antibacterial assay were conducted demonstrate potential utility this approach.

Language: Английский

---

Mo-doped ZnO NPs with NIR light enhanced peroxidase-like nanozyme and triggered photothermal for bacteria eradication

Journal of Materials Chemistry C, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

We developed Mo/ZnO NPs with excellent POD-like activity to inhibit both Gram-negative and Gram-positive bacteria. show enhanced antibacterial effects superior photothermal properties under NIR-I laser exposure.

Language: Английский

---