Immunomodulatory nanoplatforms with multiple mechanisms of action in cancer treatment DOI

Raffaella Villa,

Ya‐Ping Shiau,

Sohaib Mahri

et al.

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: May 7, 2025

Cancer immunotherapies have transformed oncology by utilizing the immune system to target malignancies; however, limitations in efficacy and potential side effects remain significant challenges. Nanoparticles shown promise enhancing drug delivery improving activation, with for numerous modifications tailor them specific environments or targets. Integrating nanoplatforms offers a promising avenue overcome these hurdles, treatment outcomes reducing adverse effects. By delivery, targeting, modulation, can unlock full of cancer immunotherapy. This review explores role addressing immunotherapy outcomes, examining various types nanoplatforms. Understanding mechanisms immunomodulation through nanoplatform deliveries is crucial. We discuss how interact tumor microenvironment, modulate tumor-associated macrophages regulatory T cells, activate cells directly, enhance antigen presentation, promote immunological memory. Further benefits include combination approaches integrating chemotherapy, radiotherapy, phototherapy. Immunotherapy relatively new approach, but clinical studies already utilize nanoplatform-based results. aims provide insights into pave way more effective personalized strategies.

Language: Английский

Nanoparticles in Drug Delivery Systems: Challenges, Innovations, And Surface Modification for Targeted Therapeutics DOI
Tasawar Abbas,

Fatima Kanwar,

Hazima Tariq

et al.

Indus journal of bioscience research., Journal Year: 2025, Volume and Issue: 3(1), P. 325 - 336

Published: Jan. 16, 2025

Nanoparticles have become a transforming platform in drug delivery systems. Their remarkable advancement over traditional methods builds upon an improvement bioavailability, stability, and controlled of therapeutic agents. Here, we discuss the broad spectrum potential nanoparticle-based Challenges, innovations, surface modification strategies that affect their clinical translation are discussed. Notwithstanding they present, challenges including biocompatibility, toxicity, targeting efficiency persist restricting extensive utilization. The review emphasizes recent advancements, stimuli-responsive nanoparticles, which provide release reaction to environmental triggers, as well targeted delivery, facilitates selective accumulation agents at designated sites disease. Besides, techniques, such PEGylation, ligand conjugation, charge modulation, been highly promising improving stability reducing immunogenicity, enhancing cellular uptake. future systems based on nanoparticles will address these through new innovations nanoparticle design effect more effective treatments. While research advances, likely bring revolution personalized medicine, tailoring medical therapy for different diseases with minimal side effects better patient outcomes.

Language: Английский

Citations

0
Smart nanomedicines powered by artificial intelligence: a breakthrough in lung cancer diagnosis and treatment DOI

Moloudosadat Alavinejad,

Moein Shirzad,

Mohammad Javad Javid-Naderi

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(5)

Published: March 25, 2025

Language: Английский

Citations

0
CAR-T and Nanotechnology: A Comparative Perspective on Autoimmune Disease and Cancer DOI Creative Commons

A.J. Pavithra,

Chinnasamy Ragavendran

Advances in Biomarker Sciences and Technology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Recent advances in nanotechnology-based diagnosis and treatment of bladder cancer: an updated review DOI Creative Commons

Keyao Hu,

Yanfang Cui, Ning Li

et al.

International Journal of Smart and Nano Materials, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 34

Published: April 19, 2025

Language: Английский

Citations

0
Nanoparticle-Based Strategies to Enhance the Efficacy of STING Activators in Cancer Immunotherapy DOI Creative Commons
Yi Qiao, Lingyu Wei,

Yinjie Su

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 5429 - 5456

Published: April 1, 2025

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway plays a critical role in triggering innate and adaptive immune responses through type I activation cell recruitment, holding significant promise for cancer therapy. While STING activators targeting this have been developed, their clinical application is hindered by challenges such as poor membrane permeability, rapid degradation, suboptimal pharmacokinetics, off-target biodistribution, toxicity. Nanoparticle-based delivery systems offer promising solution enhancing the stability, circulation time, tumor accumulation, intracellular release activators. Furthermore, combining nanoparticle-delivered with radiotherapy, chemotherapy, phototherapy, other immunotherapies enables synergistic antitumor effects multimodal mechanisms, addressing resistance to monotherapies reducing risks recurrence metastasis. This review outlines immunomodulatory mechanisms cGAS-STING pathway, surveys current STING-targeted activators, comprehensively discusses recent advances nanoparticle-mediated strategies activation. Additionally, we explore combinatorial approaches that integrate nanotherapies conventional emerging treatments. Finally, highlight status, prospects, nanoparticle-based immunotherapy.

Language: Английский

Citations

0
Enhanced Quercetin Encapsulation through Charge Density and Amphiphilicity Tuning in Cationic Triblock Micelles DOI
Ridouan El Yousfi, Leonard Ionuț Atanase,

Abderrahman Makaoui

et al.

ACS Applied Polymer Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Language: Английский

Citations

0
Immunomodulatory nanoplatforms with multiple mechanisms of action in cancer treatment DOI

Raffaella Villa,

Ya‐Ping Shiau,

Sohaib Mahri

et al.

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: May 7, 2025

Cancer immunotherapies have transformed oncology by utilizing the immune system to target malignancies; however, limitations in efficacy and potential side effects remain significant challenges. Nanoparticles shown promise enhancing drug delivery improving activation, with for numerous modifications tailor them specific environments or targets. Integrating nanoplatforms offers a promising avenue overcome these hurdles, treatment outcomes reducing adverse effects. By delivery, targeting, modulation, can unlock full of cancer immunotherapy. This review explores role addressing immunotherapy outcomes, examining various types nanoplatforms. Understanding mechanisms immunomodulation through nanoplatform deliveries is crucial. We discuss how interact tumor microenvironment, modulate tumor-associated macrophages regulatory T cells, activate cells directly, enhance antigen presentation, promote immunological memory. Further benefits include combination approaches integrating chemotherapy, radiotherapy, phototherapy. Immunotherapy relatively new approach, but clinical studies already utilize nanoplatform-based results. aims provide insights into pave way more effective personalized strategies.

Language: Английский

Citations

0