Alkaline “Nanoswords” Coordinate Ferroptosis-like Bacterial Death for Antibiosis and Osseointegration

ACS Nano, Journal Year: 2023, Volume and Issue: 17(3), P. 2711 - 2724

Published: Jan. 20, 2023

Ferroptosis is an iron-dependent cell death and associated with cancer therapy. Can it play a role in resistance of postoperative infection implants, especially extracellular supplement Fe ions non-cytotoxic dose? To answer this, "nanoswords" Fe-doped titanite are fabricated on Ti implant surface to resist bacterial invasion by synergistic action ferroptosis-like bacteria killing, proton disturbance, physical puncture. The related antibiosis mechanism explored atomic force microscopy genome sequencing. nanoswords induce increased local pH value, which not only weakens the motive force, reducing adenosine triphosphate synthesis Staphylococcus aureus, but also decreases membrane modulus, making distort even puncture easily. Simultaneously, more taken due permeability, resulting bacteria, this demonstrated intracellular iron enrichment, lipid peroxidation, glutathione depletion. Interestingly, microenvironment constructed these improves osteoblast behavior vitro bone regeneration vivo. Overall, can without cytotoxicity have great promise applications clinical implants for outstanding biointegration performance.

Language: Английский

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Ultrasound-responsive smart composite biomaterials in tissue repair

Nano Today, Journal Year: 2023, Volume and Issue: 49, P. 101804 - 101804

Published: March 4, 2023

Language: Английский

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Sonodynamic therapy-based nanoplatforms for combating bacterial infections

Ultrasonics Sonochemistry, Journal Year: 2023, Volume and Issue: 100, P. 106617 - 106617

Published: Sept. 23, 2023

The rapid spread and uncontrollable evolution of antibiotic-resistant bacteria have already become urgent global to treat bacterial infections. Sonodynamic therapy (SDT), a noninvasive effective therapeutic strategy, has broadened the way toward dealing with biofilms, which base on ultrasound (US) sonosensitizer. Sonosensitizer, based small organic molecules or inorganic nanoparticles, is essential SDT process. Thus, it meaningful design sonosensitizer-loaded nanoplatform synthesize an efficient effect. In this review, we initially summarize probable SDT-based antibacterial mechanisms systematically discuss current advancement in different (including for small-molecule sonosensitizer delivery as sonosensitizer) infection therapy. addition, biomedical applications SDT-involved multifunctional nanoplatforms are also discussed. We believe innovative would highly next-generation tool combating infection.

Language: Английский

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A Janus‐ROS Healing System Promoting Infectious Bone Regeneration via Sono‐Epigenetic Modulation

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(2)

Published: Oct. 19, 2023

Abstract Elimination of bacterial infections and simultaneously promoting osteogenic differentiation are highly required for infectious bone diseases. Massive reactive oxygen species (ROS) can damage cells, while low ROS concentrations as a molecular signal regulate cellular fate. In this study, Janus‐ROS healing system is developed regeneration. An alendronate (ALN)‐mediated defective metal–organic framework (MOF) sonosensitizer prepared, which effectively clear Methicillin‐resistant Staphylococcus aureus (MRSA) promote under differential ultrasonic irradiation. the presence zirconium–phosphate coordination, ALN‐mediated porphyrin‐based MOF (HN25) with proper defect has great sonodynamic antibacterial efficiency (98.97%, 15 min) bone‐targeting ability. Notably, low‐power ultrasound irradiation, HN25 increase chromatin accessibility ossification‐related genes FOXO1 to repair through concentrations. Animal models paravertebral infection, fracture osteomyelitis demonstrate that successfully realizes targeted potent various tissues rapid MRSA elimination, inhibiting osteoclast activity The results show high catalytic bioactive be constructed using pharmaceutical‐mediated engineering. treatment also promising therapeutic mode tissue

Language: Английский

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Sonopiezoelectric Nanomedicine and Materdicine

Small, Journal Year: 2023, Volume and Issue: 19(29)

Published: April 24, 2023

Abstract Endogenous electric field is ubiquitous in a multitude of important living activities such as bone repair, cell signal transduction, and nerve regeneration, signifying that regulating the organisms highly beneficial to maintain organism health. As an emerging promising research direction, piezoelectric nanomedicine materdicine precisely activated by ultrasound with synergetic advantages deep tissue penetration, remote spatiotemporal selectivity, mechanical‐electrical energy interconversion, have been progressively utilized for disease treatment repair participating modulation endogenous field. This specific utilizing effect typically regarded “sonopiezoelectric nanomedicine”. comprehensive review summarizes discusses substantially employed sonopiezoelectric nanomaterials nanotherapies provide insight into internal mechanism corresponding biological behavior/effect biomaterials versatile treatments. primarily focuses on biosensing, drug delivery, tumor therapy, antimicrobia, further illuminates underlying mechanism. In addition, challenges developments/prospects are analyzed promoting clinical translation. It earnestly expected this kind nanomedicine/biomaterials‐enabled technology will provoke investigation promote development next‐generation multifunctional materdicine.

Language: Английский

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