Advancements in Biosensors Based on the Assembles of Small Organic Molecules and Peptides

Biosensors, Journal Year: 2023, Volume and Issue: 13(8), P. 773 - 773

Published: July 29, 2023

Over the past few decades, molecular self-assembly has witnessed tremendous progress in a variety of biosensing and biomedical applications. In particular, self-assembled nanostructures small organic molecules peptides with intriguing characteristics (e.g., structure tailoring, facile processability, excellent biocompatibility) have shown outstanding potential development various biosensors. this review, we introduced unique properties for We first discussed applications such electrochemical biosensors as electrode supports enzymes cells signal labels large number electroactive units amplification. Secondly, utilization fluorescent nanomaterials by dyes or was introduced. Thereinto, typical examples based on target-responsive aggregation-induced emission decomposition-induced enhancement were discussed. Finally, colorimetric assays summarized. also briefly addressed challenges future prospects nanostructures.

Language: Английский

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One-step synthesis of a dual-functional AIE-active probe for ClO⁻ detection and photodynamic therapy

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(8), P. 984 - 987

Published: Jan. 1, 2024

An amphiphilic fluorescent probe (BHSMP) with aggregation-induced emission (AIE) features was synthesized via a one-step route.

Language: Английский

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Homology‐Activated Ultrasensitive Nanomedicines for Precise NIR‐II FL/MRI Imaging‐Guided “Knock‐On” Dynamic Therapy in Rheumatoid Arthritis

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(11)

Published: Jan. 14, 2024

Abstract Stimuli‐responsive nanomedicines represent a pivotal technology for in situ on‐demand drug release and offer multiple advantages over conventional delivery systems to combat rheumatoid arthritis(RA). However, the lack of sensitivity single‐stimuli source or inability synchronize multi‐stimuli responses can easily lead challenges achieving precise‐theranostics RA. Herein, homology‐activated ultrasensitive MnO 2 ‐CQ4T‐GOx(MCG NMs) is designed NIR‐II fluorescence(NIR‐II FL)/magnetic resonance imaging(MRI)‐guided effective “knock‐on” dynamic anti‐RA therapy. Building upon characteristics RA‐microenvironment, MCG innovatively construct ‐Mn 2+ system, which normalized activation sites. The ultrasensitive‐responsive degradation achieved using processes triggering functional small molecules. produced Mn exert Fenton‐like activity generate •OH from H O , thus providing chemodynamic therapy(CDT). Moreover, up‐regulation by GOx‐catalysis not only sensitizes system but also achieves self‐enhancing CDT efficacy. FL quenching CQ4T‐BSA aggregated state occurs NMs, be rapidly precisely “turn‐on” via system. Meanwhile, integration activated ‐based MRI imaging has successfully developed an activatable dual‐modal imaging. Feedback imaging‐guided precise photodynamic therapy achieve efficient

Language: Английский

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Biomarker-activatable photosensitizers with aggregation-induced emission characteristics for photodynamic therapy

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 518, P. 216056 - 216056

Published: July 3, 2024

Language: Английский

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Design strategies for organelle-selective fluorescent probes: where to start?

RSC Advances, Journal Year: 2025, Volume and Issue: 15(3), P. 2115 - 2131

Published: Jan. 1, 2025

Advancing the development of organelle-targeted small fluorescent probes by highlighting key design strategies to reveal cellular dynamics and address persistent challenges in probe design.

Language: Английский

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