Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Aug. 26, 2023
Abstract
With
the
discovery
of
intrinsic
enzyme‐like
activity
metal
oxides,
nanozymes
garner
significant
attention
due
to
their
superior
characteristics,
such
as
low
cost,
high
stability,
multi‐enzyme
activity,
and
facile
preparation.
Notably,
in
field
biomedicine,
primarily
focus
on
disease
detection,
antibacterial
properties,
antitumor
effects,
treatment
inflammatory
conditions.
However,
potential
for
application
regenerative
medicine,
which
addresses
wound
healing,
nerve
defect
repair,
bone
regeneration,
cardiovascular
treatment,
is
garnering
interest
well.
This
review
introduces
an
innovative
strategy
within
realm
medicine.
The
primary
this
approach
lies
facilitation
osteochondral
regeneration
through
modulation
pathological
microenvironment.
catalytic
mechanisms
four
types
representative
are
first
discussed.
microenvironment
inhibiting
followed
by
summarizing
therapy
mechanism
barriers
introduced.
Further,
therapeutic
diseases
included.
To
improve
efficiency
facilitate
clinical
translation,
future
applications
also
discussed
some
challenges
addressed.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 10, 2025
Abstract
Open
wounds
damage
the
integrity
of
injured
tissues
and
expose
them
to
bacterial
infections.
Traditional
suturing
often
lead
reinjuring
damaged
tissues.
This
delays
healing
process,
especially
in
presence
a
infection.
A
Janus
hydrogel
adhesive
with
bio‐adhesion
multi‐mode
disinfection
(BAMD)
capabilities
(a
BAMD
hydrogel)
is
developed
using
spin‐coating
which
can
serve
as
an
alternative
traditional
sutures.
The
organic–inorganic
hybrid
combination
Chinese‐medicine
organic
small
molecule
rhein
(Rhe)
graphene
oxide
(GO)
endows
dual‐mode
antibacterial
activity
driven
by
photodynamic
(PD)
photothermal
(PT)
effects
including
short‐term
rapid
(15‐min
irradiation,
99.95%
bactericidal
rate)
long‐term
action
absence
light
(100%
rate
after
6
h
dark
incubation).
vivo
results
demonstrated
97.25%
against
MRSA.
Throughout
wound
recovery
effectively
reduced
inflammation
promoted
tissue
healing.
versatile
strategy
offers
new
insights
into
preventing
postoperative
adhesion
sealing
repairing
large‐scale
damage.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: July 22, 2024
Abstract
Rheumatoid
arthritis
(RA)
is
an
autoimmune
disease
with
multifactorial
etiology
and
intricate
pathogenesis.
In
RA,
repeated
monotherapy
frequently
associated
inadequate
efficacy,
drug
resistance,
severe
side
effects.
Therefore,
a
shift
has
occurred
in
clinical
practice
toward
combination
therapy.
However,
conventional
therapy
encounters
several
hindrances,
including
low
selectivity
to
arthritic
joints,
short
half-lives,
varying
pharmacokinetics
among
coupled
drugs.
Emerging
nanotechnology
offers
incomparable
opportunity
for
developing
advanced
against
RA.
First,
it
allows
co-delivering
multiple
drugs
augmented
physicochemical
properties,
targeted
delivery
capabilities,
controlled
release
profiles.
Second,
enables
therapeutic
nanomaterials
development,
thereby
expanding
regimens
include
multifunctional
nanomedicines.
Lastly,
facilitates
the
construction
of
all-in-one
nanoplatforms
assembled
modalities,
such
as
phototherapy,
sonodynamic
therapy,
imaging.
Thus,
promising
solution
current
bottleneck
both
RA
treatment
diagnosis.
This
review
summarizes
rationale,
advantages,
recent
advances
nano-empowered
It
also
discusses
safety
considerations,
drug–drug
interactions,
potential
translation.
Additionally,
provides
design
tips
outlook
on
future
developments
The
objective
this
achieve
comprehensive
understanding
mechanisms
underlying
unlock
maximum
nanotechnology,
facilitating
smooth
transition
research
findings
from
laboratory
practice.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Aug. 26, 2023
Abstract
With
the
discovery
of
intrinsic
enzyme‐like
activity
metal
oxides,
nanozymes
garner
significant
attention
due
to
their
superior
characteristics,
such
as
low
cost,
high
stability,
multi‐enzyme
activity,
and
facile
preparation.
Notably,
in
field
biomedicine,
primarily
focus
on
disease
detection,
antibacterial
properties,
antitumor
effects,
treatment
inflammatory
conditions.
However,
potential
for
application
regenerative
medicine,
which
addresses
wound
healing,
nerve
defect
repair,
bone
regeneration,
cardiovascular
treatment,
is
garnering
interest
well.
This
review
introduces
an
innovative
strategy
within
realm
medicine.
The
primary
this
approach
lies
facilitation
osteochondral
regeneration
through
modulation
pathological
microenvironment.
catalytic
mechanisms
four
types
representative
are
first
discussed.
microenvironment
inhibiting
followed
by
summarizing
therapy
mechanism
barriers
introduced.
Further,
therapeutic
diseases
included.
To
improve
efficiency
facilitate
clinical
translation,
future
applications
also
discussed
some
challenges
addressed.
