Three‐Dimensional Printing Applications for Bone Tissue Engineering: A Review DOI Open Access
Saeedeh Zare Jalise, Arezou Mehrabi, Sina Habibi

et al.

Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(4)

Published: March 31, 2025

ABSTRACT 3D printing technology has shown significant promise in bone tissue engineering, enabling the fabrication of intricate structures while controlling porosity and mechanical properties. Integrating into provides a vital benefit by allowing implants to precisely match an individual's anatomy, improving outcomes reducing risk rejection. Additionally, this approach supports inclusion bioactive substances growth factors enhance regeneration. This study examines most recent advances for production, stressing their potential regenerative medicine personalized healthcare. It also addresses challenges associated with current processes engineering explores possible avenues future research development. Furthermore, article investigates how biocompatibility bioactivity materials used facilitate effective Likewise, it evaluates scaffold design architecture can promote cell attachment, proliferation, differentiation, thereby encouraging successful restoration. In conclusion, thorough assessment offers critical insights progress obstacles proposes directions inquiry exciting field. By leveraging these advancements, clinicians researchers pioneer new therapies that address defects improve outcomes.

Language: Английский

Bioactive Inorganic Materials for Innervated Multi‐Tissue Regeneration DOI Creative Commons
Hongjian Zhang, Ziyi Zhao, Chengtie Wu

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Tissue engineering aims to repair damaged tissues with physiological functions recovery. Although several therapeutic strategies are there for tissue regeneration, the functional recovery of regenerated still poses significant challenges due lack concerns innervation. Design rationale multifunctional biomaterials both tissue-induction and neural induction activities shows great potential regeneration. Recently, research application inorganic attracts increasing attention in innervated multi-tissue such as central nerves, bone, skin, because its superior tunable chemical composition, topographical structures, physiochemical properties. More importantly, easily combined other organic materials, biological factors, external stimuli enhance their effects. This review presents a comprehensive overview recent advancements It begins introducing classification properties typical design inorganic-based material composites. Then, progresses regenerating various nerves nerve-innervated systematically reviewed. Finally, existing future perspectives proposed. may pave way direction offers new strategy regeneration combination

Language: Английский

Citations

1
Bone tissue engineering for osteointegration: Where are we now? DOI Creative Commons
Damla Aykora, Metehan Uzun

Polymer Bulletin, Journal Year: 2024, Volume and Issue: 81(10), P. 8595 - 8605

Published: Feb. 3, 2024

Abstract Bone fracture healing is a challenging process, due to insufficient and slow tissue repair. Sufferers from bone fractures struggle with one-third of nonunion, display graft rejection, high-costed implantation, or chronic pain. Novel advances in engineering presented promising options for this strain. Biomaterials repair allow accelerated regeneration, osteoblastic cell activation, enhanced remodeling. There wide range biomaterials that are biocompatible, bioresorbable, biodegradable used promoting osteoconductive osteoinductive properties. The main aim generate rapid optimal functional regeneration through combination biomaterials, growth factors, cells, various agents. Recently has been attracted the use bioactive glass scaffolds incorporated polymers patient-specific fabrication material by 3D bioprinting. future outcomes were reported several research. present review provides an outlook recent most common suggesting practices should have proceeded clinical application.

Language: Английский

Citations

8
Harnessing cerium-based biomaterials for the treatment of bone diseases DOI
Xiang Meng,

Wen-Da Wang,

Su-Ran Li

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 183, P. 30 - 49

Published: June 5, 2024

Language: Английский

Citations

7
Multifunctional CeO2 nanozymes for mitigating high-glucose induced senescence and enhancing bone regeneration in type 2 diabetes mellitus DOI Creative Commons
Zhuoran Wang, Yilin Zhang,

Sishi Chen

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 485, P. 149842 - 149842

Published: Feb. 19, 2024

Healing bone defects in patients with type 2 diabetes mellitus (T2DM) has long been a challenging issue. Elevated blood sugar levels T2DM lead to the overproduction of reactive oxygen species (ROS), which negatively affects mitochondrial function, induces senescence marrow mesenchymal stem cells (BMSCs), and diminishes their osteoblastic potential. In this study, we developed polyacrylic acid modified cerium oxide nanoparticles (PCNPs), biocompatible, water-soluble, antioxidant nanozyme. Our vitro experiments demonstrated that PCNPs effectively eliminated ROS, restored significantly upregulated AMPK-SIRT1-PGC1α signaling pathway, ultimately mitigating BMSCs senescence. Considering clinical applications, have also investigated synergistic effects material systems for sustained release vivo. This sustained-release system proved be more effective promoting defect healing rats. These findings introduce promising innovative approach managing using customized multifunctional nanozymes.

Language: Английский

Citations

6
Nanozymes With Osteochondral Regenerative Effects: An Overview of Mechanisms and Recent Applications DOI

Xueheng Sun,

Xu Xiang, Xiaokun Yue

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(1)

Published: Aug. 26, 2023

Abstract With the discovery of intrinsic enzyme‐like activity metal oxides, nanozymes garner significant attention due to their superior characteristics, such as low cost, high stability, multi‐enzyme activity, and facile preparation. Notably, in field biomedicine, primarily focus on disease detection, antibacterial properties, antitumor effects, treatment inflammatory conditions. However, potential for application regenerative medicine, which addresses wound healing, nerve defect repair, bone regeneration, cardiovascular treatment, is garnering interest well. This review introduces an innovative strategy within realm medicine. The primary this approach lies facilitation osteochondral regeneration through modulation pathological microenvironment. catalytic mechanisms four types representative are first discussed. microenvironment inhibiting followed by summarizing therapy mechanism barriers introduced. Further, therapeutic diseases included. To improve efficiency facilitate clinical translation, future applications also discussed some challenges addressed.

Language: Английский

Citations

16
Microwave-Assisted Hydrothermal Treatment of Multifunctional Substituted Hydroxyapatite with Prospective Applications in Bone Regeneration DOI Creative Commons

Alexandra-Cristina Burdușel,

Ionela Andreea Neacșu, Alexandra Cătălina Bîrcă

et al.

Journal of Functional Biomaterials, Journal Year: 2023, Volume and Issue: 14(7), P. 378 - 378

Published: July 19, 2023

Orthopedic bone graft infections are major complications in today's medicine, and the demand for antibacterial treatments is expanding because of spread antibiotic resistance. Various compositions hydroxyapatite (HAp) which Calcium (Ca2+) ions substituted with Cerium (Ce3+) Magnesium (Mg2+) herein proposed as biomaterials hard tissue implants. This approach gained popularity recent years and, pursuit mimicking natural mineral's composition, over 70 elements Periodic Table were already reported substituents into HAp structure. The current study aimed to create materials based on HAp, Hap-Ce, Hap-Mg using hydrothermal maturation microwave field. route has been considered a novel, promising, effective way obtain monodisperse, fine nanoparticles while easily controlling synthesis parameters. synthesized powders characterized morphologically structurally by XRD diffraction, Dynamic light scattering, zeta potential, FTIR spectrometry, SEM analysis. Proliferation morphological analysis osteoblast cell cultures used demonstrate cytocompatibility produced biomaterials. antimicrobial effect was highlighted samples, especially cerium. Therefore, samples cerium or magnesium enhanced osseointegration, also having capacity reduce device-associated infections.

Language: Английский

Citations

15
P2O5 enhances the bioactivity of lithium silicate glass ceramics via promoting phase transformation and forming Li3PO4 DOI
Ning-Ze Zhang, Min Zhang, Hongyan Tang

et al.

Ceramics International, Journal Year: 2024, Volume and Issue: 50(8), P. 13308 - 13317

Published: Jan. 18, 2024

Language: Английский

Citations

5
Photothermal Catalytic Reduction and Bone Tissue Engineering Towards a Three‐in‐One Therapy Strategy for Osteosarcoma DOI

Hengli Lu,

Zihua Li,

Zhengwei Duan

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 20, 2024

Abstract Osteosarcoma is one of the most dreadful bone neoplasms in young people, necessitating development innovative therapies that can effectively eliminate tumors while minimizing damage to limb function. An ideal therapeutic strategy should possess three essential capabilities: antitumor effects, tissue‐protective properties, and ability enhance osteogenesis. In this study, self‐assembled Ce‐substituted molybdenum blue (CMB) nanowheel crystals are synthesized loaded onto 3D‐printed bioactive glass (CMB@BG) scaffolds develop a unique three‐in‐one treatment approach for osteosarcoma. The CMB@BG exhibit outstanding photothermally derived tumor ablation within near‐infrared‐II window due surface plasmon resonance properties CMB crystals. Furthermore, synergistic catalytic effect promotes rapid scavenging reactive oxygen species caused by excessive heat, thereby suppressing inflammation protecting surrounding tissues. pro‐proliferation pro‐differentiation capabilities efficiently accelerate regeneration defects. Altogether, combine highly efficient ablation, tissue protection based on anti‐inflammatory mechanisms, enhanced osteogenic likely be point‐to‐point solution comprehensive needs

Language: Английский

Citations

4
Cerium-based materials in burn wound healing: development, mechanism and outlook DOI Creative Commons
Mengzhen Zhang, Yucong Li, Xinzhu Liu

et al.

Regenesis repair rehabilitation., Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Preparation and characterization of mesoporous core-shell bioactive glass-based cements for direct pulp capping DOI

Xiaoting Xu,

Yehong He,

Xiaochen Chen

et al.

Biomedical Materials, Journal Year: 2025, Volume and Issue: 20(2), P. 025022 - 025022

Published: Jan. 31, 2025

Direct pulp capping is crucial for maintaining dental vitality. The materials employed this purpose should possess properties such as easy-handling, excellent biocompatibility, infection resistance, and the ability to stimulate formation of reparative dentin. Mineral trioxide aggregate (MTA) commonly used capping. However, certain limitations, including its long setting time, insufficient anti-washout ability, high initial curing pH, handling difficulties, restrict MTA from meeting a broader range clinical demands. Bioactive glass (BG) known osteo-inductive bone restoration properties. This study aims develop novel BG-based cement (BG-x/SA) applications, using BG microspheres (BG-x) solid phase sodium alginate solution (SA) liquid phase. has core-shell made byin-situtransformation, with in core hydroxyapatite shell. focuses on how thein-situsynthesis reaction parameters affect cement's Ultimately, BG-6/SA was identified optimal formulation, comparison shows short good performance, can adjust pH mildly alkaline, promotes dentin formation, antibacterial effects. Thus, significant research value prospects new pulp-capping material.

Language: Английский

Citations

0