The evolution of immune profiling: will there be a role for nanoparticles? DOI
Olga E. Eremina,

Celine Vazquez,

Kimberly N. Larson

et al.

Nanoscale Horizons, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Immune profiling provides insights into functioning of the immune system: distribution, abundance and activity cells. Nanoparticles can offer a versatile approach to profile system with improved efficiency multiplexed imaging power.

Language: Английский

Microplastics/nanoplastics and Neurological Health: An Overview of Neurological Defects and Mechanisms DOI
Junjie Sun,

Siwan Peng,

Qiongxia Yang

et al.

Toxicology, Journal Year: 2024, Volume and Issue: 511, P. 154030 - 154030

Published: Dec. 7, 2024

Language: Английский

Citations

2
In Situ and In Vivo Evaluation of Multiplex Protein-Specific Glycosylation of Tumors with a Dual-SERS Encoding Strategy DOI
Shan Wu, Yuru Wang, Yuhui Yang

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 97(1), P. 936 - 944

Published: Dec. 20, 2024

A dual-SERS encoding strategy was designed for in situ and vivo evaluation of multiplex protein-specific glycosylation tumors. The consisted two pairs dual gold nanoprobes with different diameters 10 30 nm, which were encoded four distinguishable Raman signal molecules. nm (Au10 Au30 probes, respectively) further modified lectins aptamers to recognize the target glycans proteins, respectively. After sequential binding adjacent Au10 probes could emit strong surface-enhanced scattering (SERS) signals indicate information on cells vivo, can reveal distribution differences tumor markers central marginal regions This has been successfully applied imaging MUC1 EpCAM-specific Sia Gal/GalNAc cell surfaces xenografted mice, providing a convenient powerful tool study glycosylation-related physiological pathological mechanisms.

Language: Английский

Citations

1
Rapid controllable synthesis of branched Au superparticles: formation mechanism of toggling the growth mode and their applications in optical broadband absorption DOI Creative Commons
Shichuan Zhong, Lifeng Hang, Lulu Wen

et al.

Nanoscale Advances, Journal Year: 2023, Volume and Issue: 5(6), P. 1776 - 1783

Published: Jan. 1, 2023

We develop a tunable, ultra-fast (5 seconds) synthetic method to fabricate branched Au superparticles by wet chemical route, the special growth mechanism of toggling mode is revealed and confirmed.

Language: Английский

Citations

3
Growth‐Induced Extinction Development of Gold Nanoclusters as Signal Transducers for Quantitative Immunoassays DOI Creative Commons

Bong‐Geun Kim,

Yu Rim Choi,

Yerin Kim

et al.

Advanced Materials Interfaces, Journal Year: 2024, Volume and Issue: 11(24)

Published: June 24, 2024

Abstract Signal transducers are crucial in bioassay platforms for converting target detection into recordable signals. Commonly used color development immunoassays involves enzymes and colorimetric substrates. However, due to cost environmental issues, practical point‐of‐care testing requires alternative signal transducers. Growth‐induced extinction (absorption scattering) of gold nanoclusters (AuNCs) is proposed as a novel approach quantitative immunoassays. AuNCs devoid localized surface plasmon resonance (LSPR) seeds growth reactions. Through reactions with solution comprised precursor mild reductant, varying concentrations underwent controlled growth, resulting nanoparticles different sizes exhibiting distinct LSPR‐mediated bands. Notably, the seed concentration exhibited robust correlation grown particles on small scale 110 µL 96‐well microplate platform. To demonstrate this transduction mechanism, immunosorbent assays performed using conjugates AuNC antibody. The sandwich‐type assay successfully quantified model antigen, human immunoglobulin G (hIgG), by monitoring LSPR wavelength absorbance. This demonstrated working range 0.001–1 µg mL −1 limit 1.19 ng . offer new candidates immunoassay platforms.

Language: Английский

Citations

0
The evolution of immune profiling: will there be a role for nanoparticles? DOI
Olga E. Eremina,

Celine Vazquez,

Kimberly N. Larson

et al.

Nanoscale Horizons, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Immune profiling provides insights into functioning of the immune system: distribution, abundance and activity cells. Nanoparticles can offer a versatile approach to profile system with improved efficiency multiplexed imaging power.

Language: Английский

Citations

0