Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: 229, P. 116523 - 116523
Published: Sept. 7, 2024
Language: Английский
Trends in biotechnology, Journal Year: 2023, Volume and Issue: 42(4), P. 479 - 495
Published: Nov. 13, 2023
The eradication of drug-resistant microbial biofilms remains an unresolved global health challenge. Small-scale robotics are providing innovative therapeutic and diagnostic approaches with high precision efficacy. These rapidly moving from proof-of-concept studies to translational biomedical applications using ex vivo, animal, clinical models. Here, we discuss the fundamental aspects how microrobots target infection sites disrupt structural functional traits their antimicrobial resistance mechanisms. We emphasize current mechanochemical disruption on-site drug delivery that supported by in vivo models preclinical testing, while also highlighting diagnostics potential. translation challenges provide perspectives for development microrobotics combat biofilm infections biofouling humans.
Language: Английский
Citations
17
International Endodontic Journal, Journal Year: 2024, Volume and Issue: 57(7), P. 861 - 871
Published: May 18, 2024
Microorganisms are the primary aetiological factor of apical periodontitis. The goal endodontic treatment is to prevent and eliminate infection by removing microorganisms. However, microbial biofilms complex root canal anatomy impair disinfection process. Effective precise therapy could potentially be achieved using advanced multifunctional technologies that have ability access hard-to-reach surfaces perform simultaneous biofilm killing, removal, detection Advances in microrobotics providing novel therapeutic diagnostic opportunities with high precision efficacy address current biofilm-related challenges biomedicine. Concurrently, magnetic microrobots been developed overcome approaches disrupt, kill, retrieve enhancing therapy. This article reviews recent advances healthcare particularly endodontics, provides perspectives for future research field.
Language: Английский
Citations
8
Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(30)
Published: July 15, 2024
Autonomous nanorobots represent an advanced tool for precision therapy to improve therapeutic efficacy. However, current nanorobotic designs primarily rely on inorganic materials with compromised biocompatibility and limited biological functions. Here, we introduce enzyme-powered bacterial outer membrane vesicle (OMV) nanorobots. The immobilized urease the OMV catalyzes decomposition of bioavailable urea, generating effective propulsion This nanorobot preserves unique features OMVs, including intrinsic biocompatibility, immunogenicity, versatile surface bioengineering desired biofunctionalities, capability cargo loading protection. We present OMV-based designed tumor by leveraging properties OMVs. These involve robotic body cell-penetrating peptide targeting penetration, which is further enhanced active Additionally, can effectively safeguard loaded gene silencing tool, small interfering RNA (siRNA), from enzymatic degradation. Through systematic in vitro vivo studies using a rodent model, demonstrate that these substantially siRNA delivery immune stimulation, resulting utmost effectiveness suppression when juxtaposed static groups, particularly evident orthotopic bladder model. opens inspiring avenue design medical robots expanded versatility adaptability, broadening their operation scope practical biomedical domains.
Language: Английский
Citations
8
ACS Nano, Journal Year: 2024, Volume and Issue: 18(29), P. 19391 - 19400
Published: June 21, 2024
Robotic nanomanipulation emerges as a cutting-edge technique pivotal for in situ nanofabrication, advanced sensing, and comprehensive material characterization. In this study, we develop an optical robotic platform (ORP) the dynamic manipulation of colloidal nanoparticles (NPs). The ORP incorporates human-in-the-loop control mechanism enhanced by real-time visual feedback. This feature enables generation custom landscapes with adjustable intensity phase configurations. Based on ORP, achieve parallel reconfigurable multiple NPs. Through application spatiotemporal gradient-reversals, our demonstrates capabilities trapping, binding, rotating, transporting NPs across trajectories. presents previously unidentified paradigm realm nanomanipulation. Additionally, facilities "capture-and-print" assembly process, utilizing strategic interplay gradients. process operates under constant laser power setting, streamlining into any targeted configuration. With its precise positioning capabilities, underpinned modulation gradients, will facilitate development colloid-based sensors on-demand fabrication nanodevices.
Language: Английский
Citations
7
Nano Materials Science, Journal Year: 2024, Volume and Issue: unknown
Published: June 1, 2024
Micro/nanoscale robots (MNRs) have attracted significant interest in various fields because of their flexible design, physically controlled maneuvering, and barrier targeting. The execution specific functions using MNRs relies on precise propulsion methods. Among the diverse techniques, physical is widely used owing to its noninvasive, safe, convenient attributes. This review provides an analysis mechanisms magnetic, electric, thermal, ultrasound presents a comprehensive summary structures, movements, applications while also examining advantages shortcomings associated with Finally, challenges perspectives future development are presented. content this can serve as multidisciplinary science reference for physicists, bioengineers, clinicians, roboticists, chemists involved pharmaceutical design clinical therapy research.
Language: Английский
Citations
4
Advanced Science, Journal Year: 2024, Volume and Issue: 11(30)
Published: June 13, 2024
Individual differences in size, experience, and task specialization natural swarms often result heterogeneity hierarchy, facilitating efficient coordinated accomplishment. Drawing inspiration from this phenomenon, a general strategy is proposed for organizing magnetic micro/nanorobots (MNRs) with apparent shape, properties into cohesive microswarms tunable heterogeneity, controlled spatial collaborative tasking capability. In strategy, disparate MNRs can be manipulated to show reversible transitions between synchronization desynchronization by elaborately regulating parameter sets of the rotating field. Utilizing these transitions, alongside local robust hydrodynamic interactions, diverse heterospecific pairings organized heterogeneous microswarms, their organization dynamically adjusted egalitarian leader-follower-like hierarchies on fly, both open space complex microchannels. Furthermore, when specializing distinct functions ("division labor") such as sensing drug carrying, they execute precise delivery targeting unknown sites sensing-navigating-cargo dropping sequence, demonstrating significant potential tumor treatment. These findings highlight critical roles attribute hierarchical designing swarming biomedical applications.
Language: Английский
Citations
4
Journal of Magnetism and Magnetic Materials, Journal Year: 2023, Volume and Issue: 586, P. 171160 - 171160
Published: Sept. 1, 2023
Language: Английский
Citations
10
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 13, 2025
Microrobots are poised to transform biomedicine by enabling precise, noninvasive procedures. However, current magnetic microrobots, composed of solid monolithic particles, present fundamental challenges in engineering intersubunit interactions, limiting their collective effectiveness navigating irregular biological terrains and confined spaces. To address this, we design hierarchically assembled microrobots with multiaxis mobility adaptability the potential interaction energy between subunits create stable, self-reconfigurable structures capable carrying protecting cargo internally. Using double emulsion templates control techniques, confine 10 nm iron oxide 15 silica nanoparticles within shell 100 μm microcapsules that form multiunit robotic collectives. Unexpectedly, find asymmetric localization enhances intercapsule energy, creating stable connections under rotating fields without altering susceptibility. These microcapsule collectives exhibit emergent behaviors, self-reconfiguring into kinematic chain-like traverse complex obstacles, arched confinements, adhesive, rugged tissues typically impede microscale systems. By harnessing these functions, demonstrate targeted antifungal delivery using a localized biofilm model on mucosal tissues, showing effective killing ofCandida binding or causing physical damage host cells. Our findings show how hierarchical assembly can produce cargo-carrying collective, self-adaptive for traversing environments, advancing biomedical applications.
Language: Английский
Citations
0
Nature Machine Intelligence, Journal Year: 2025, Volume and Issue: unknown
Published: March 19, 2025
Language: Английский
Citations
0
Published: March 22, 2025
ABSTRACT Minimally invasive transcatheter embolization is a widely utilized in interventional radiology to occlude blood vessels for treating range of diseases and vascular injuries. Various embolic agents, such as metallic coils, microspheres, liquid‐based are delivered the target site effectively block flow achieve vessel occlusion. However, precise selective deployment these agents into lesions remains challenge due limited steerability maneuverability current catheter systems. This review provides comprehensive overview recent advancements delivery devices, with particular focus on emerging robot‐assisted technologies. It also discusses key challenges associated materials explores future trends shaping field.
Language: Английский
Citations
0