Engineered Probiotic Bio‐heterojunction with Robust Antibiofilm Modality via “Eating” Extracellular Polymeric Substances for Wound Regeneration

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(35)

Published: June 25, 2024

The compact three-dimensional (3D) structure of extracellular polymeric substances (EPS) within biofilms significantly hinders the penetration antimicrobial agents, making biofilm eradication challenging and resulting in persistent biofilm-associated infections. To address this challenge, a solution is proposed: probiotic bio-heterojunction (P-bioHJ) combining Lactobacillus rhamnosus with MXene (Ti

Language: Английский

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Nanotechnology in healthcare, and its safety and environmental risks

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 15, 2024

Abstract Nanotechnology holds immense promise in revolutionising healthcare, offering unprecedented opportunities diagnostics, drug delivery, cancer therapy, and combating infectious diseases. This review explores the multifaceted landscape of nanotechnology healthcare while addressing critical aspects safety environmental risks associated with its widespread application. Beginning an introduction to integration we first delved into categorisation various materials employed, setting stage for a comprehensive understanding potential. We then proceeded elucidate diverse applications nanotechnology, spanning medical tissue engineering, targeted gene development antimicrobial agents. The discussion extended current situation surrounding clinical translation commercialisation these cutting-edge technologies, focusing on nanotechnology-based products that have been approved globally date. also discussed considerations nanomaterials, both terms human health impact. presented vivo nanomaterial exposure, relation transport mechanisms, oxidative stress, physical interactions. Moreover, highlighted risks, acknowledging potential implications ecosystems biodiversity. Lastly, strived offer insights regulatory governing across different regions globally. By synthesising perspectives, underscore imperative balancing innovation stewardship, charting path forward responsible healthcare. Graphical abstract

Language: Английский

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Functional probes for the diagnosis and treatment of infectious diseases

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: June 25, 2024

Abstract Infectious diseases present significant challenges to global health, thereby extensively affecting both human society and the economy. In recent years, functional probes have demonstrated remarkable potential as crucial biomedical media for research treatment of infectious diseases. Their applications in realm include pathogen detection, exploration biological mechanisms, development anti‐infective drugs. This review provides a concise introduction severity, classification, pathogenesis Subsequently, we examined distinctiveness design strategies diagnosing treating diseases, shedding light on their rationale using typical examples. We discuss current status associated with clinical implementation probes. Furthermore, explored prospects these diagnosis aims offer novel insights into diagnostic broaden disease treatment.

Language: Английский

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Drug in Drug: Quorum Sensing Inhibitor in Star-Shaped Antibacterial Polypeptides for Inhibiting and Eradicating Corneal Bacterial Biofilms

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Biofilm-related bacterial keratitis is a severe ocular infection that can result in drastic vision impairment and even blindness. However, the therapeutic efficiency of clinical antibiotic eyedrops often compromised because bacteria biofilms resist bactericide

Language: Английский

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The Art of War with Pseudomonas aeruginosa: Targeting Mex Efflux Pumps Directly to Strategically Enhance Antipseudomonal Drug Efficacy

Antibiotics, Journal Year: 2023, Volume and Issue: 12(8), P. 1304 - 1304

Published: Aug. 9, 2023

Pseudomonas aeruginosa (P. aeruginosa) poses a grave clinical challenge due to its multidrug resistance (MDR) phenotype, leading severe and life-threatening infections. This bacterium exhibits both intrinsic various antipseudomonal agents acquired against nearly all available antibiotics, contributing MDR phenotype. Multiple mechanisms, including enzyme production, loss of outer membrane proteins, target mutations, efflux systems, contribute antimicrobial resistance. The importance addressing in P. is paramount, one pivotal determinant the resistance-nodulation-division (RND) family drug/proton antiporters, notably Mex pumps. These pumps function as crucial defenders, reinforcing emergence extensively drug-resistant (XDR) pandrug-resistant (PDR) strains, which underscores urgency situation. Overcoming this necessitates exploration development potent pump inhibitors (EPIs) restore efficacy existing drugs. By effectively countering or bypassing activities, EPIs hold tremendous potential for restoring antibacterial activity other Gram-negative pathogens. review focuses on concurrent MDR, highlighting significance pumps, particularly driving MDR. It explores promising delves into structural characteristics MexB subunit substrate binding sites.

Language: Английский

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Type I Photosensitizer Targeting Glycans: Overcoming Biofilm Resistance by Inhibiting the Two‐Component System, Quorum Sensing, and Multidrug Efflux

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(52)

Published: Nov. 17, 2023

Stubborn biofilm infections pose serious threats to human health due the persistence, recurrence, and dramatically magnified antibiotic resistance. Photodynamic therapy has emerged as a promising approach combat biofilm. Nevertheless, how inhibit bacterial signal transduction system efflux pump conquer recurrence resistance remains challenging unaddressed issue. Herein, boric acid-functionalized lipophilic cationic type I photosensitizer, ACR-DMP, is developed, which efficiently generates •OH overcome hypoxic microenvironment photodynamically eradicates methicillin-resistant Staphylococcus aureus (MRSA) biofilms. Furthermore, it not only alters membrane potential homeostasis osmotic pressure balance its strong binding ability with plasma but also inhibits quorum sensing two-component system, reduces virulence factors, regulates activity of drug attributed glycan-targeting ability, helping prevent In vivo, ACR-DMP successfully obliterates MRSA biofilms attached implanted medical catheters, alleviates inflammation, promotes vascularization, thereby combating accelerating wound healing. This work provides an efficient strategy stubborn multidrug offers systematic guidance for rational design next-generation advanced antimicrobial materials.

Language: Английский

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Nanotechnology‐driven strategies to enhance the treatment of drug‐resistant bacterial infections

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(3)

Published: May 1, 2024

Abstract The misuse of antibiotics has led to increased bacterial resistance, posing a global public health crisis and seriously endangering lives. Currently, antibiotic therapy remains the most common approach for treating infections, but its effectiveness against multidrug‐resistant bacteria is diminishing due slow development new increase drug resistance. Consequently, developing a\ntimicrobial strategies improving efficacy combat infection become an urgent priority. emergence nanotechnology revolutionized traditional treatment, presenting opportunities refractory infection. Here we comprehensively review research progress in nanotechnology‐based antimicrobial delivery highlight diverse platforms designed target different resistance mechanisms. We also outline use combining with other therapeutic modalities enhance drug‐resistant infections. These innovative have potential susceptibility overcome Finally, challenges prospects application nanomaterial‐based combating are discussed. This article categorized under: Biology‐Inspired Nanomaterials > Nucleic Acid‐Based Structures Therapeutic Approaches Drug Discovery Nanomedicine Infectious Disease

Language: Английский

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Microenvironment‐Adaptive Metallo‐Polymeric Nanodecoys via Subcomponent Coordination for Bacterial Biofilm Eradication and Immunomodulation

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)

Published: May 27, 2024

Abstract Biofilm‐associated infections pose complex challenges that require addressing the multifaceted requirements of biofilm disruption, bacterial killing, and immunomodulation. In this study, microenvironment‐adaptive metallo‐polymeric nanodecoys (MPNs) are synthesized through one‐pot subcomponent coordination in aqueous solution, effectively eradicating biofilms modulating immune response. Within acidic microenvironment biofilms, positively charged MPNs demonstrated ability to interact with eliminate bacteria while facilitating a Fenton‐like reaction for efficient eradication biofilms. As local shifted from neutral basic state during subsequent tissue healing processes, adaptively harness multiple properties bind pathogen‐associated molecular patterns, scavenge reactive oxygen species, thereby response, alleviating inflammation, promoting healing. This study presents an strategy preparing enzyme‐mimicking materials closely resemble natural metalloenzymes, offer alternative current antibiotic treatments biofilm‐associated infections.

Language: Английский

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Research Progress on the Combination of Quorum-Sensing Inhibitors and Antibiotics against Bacterial Resistance

Molecules, Journal Year: 2024, Volume and Issue: 29(7), P. 1674 - 1674

Published: April 8, 2024

Bacterial virulence factors and biofilm development can be controlled by the quorum-sensing (QS) system, which is also intimately linked to antibiotic resistance in bacteria. In previous studies, many researchers found that inhibitors (QSIs) affect of bacterial biofilms prevent synthesis factors. However, QSIs alone have a limited ability suppress Fortunately, when are combined with antibiotics, they better therapeutic effect, it has even been demonstrated two together synergistic antibacterial not only ensures bactericidal efficiency but avoids caused excessive use antibiotics. addition, some progress made through vivo studies on combination This article mainly expounds specific effect antibiotics bacteria mechanism These will provide new strategies means for clinical treatment infections future.

Language: Английский

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Excellent Foliar Deposition of Cyclodextrin‐Encapsulated Furyl/Thienyl‐Engineered Ingredients: Novel Effective Supramolecular Agrochemicals for Combating Plant Bacterial and Fungal Infections

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(40)

Published: May 25, 2024

Abstract Repeated epidemics caused by bacterial and fungal diseases pose a threat to global crop yields food security, therefore, updating the structure of existing microbicides improving pesticide bioavailability are challenging tasks, perhaps planning develop versatile supramolecular antimicrobial materials. Here, low‐cost multifunctional complex, named FT6@ β ‐CD, is constructed host‐guest encapsulation thienyl‐engineered ingredient (FT6) into ‐cyclodextrin. This integrated architecture can significantly reduce bounce splash behaviors droplets, improve wetting performance, eventually acquire excellent foliar deposition targeted delivery. Whereafter, ‐CD inhibit transcription type III secretion system (T3SS)‐associated genes, hypersensitive reaction, final pathogenicity from destructive pathogen Xanthomonas oryzae pv. ( Xoo ). Importantly, at lower dosage 200 µg mL −1 , presented in vivo control effects (protection 48.1%, curative 50.1%) against remarkably better than commercial bactericidal formulation thiodiazole‐copper. Additionally, other antifungal materials (FT24/FT25@HP‐ ‐CD/ ‐CD/Me‐ ‐CD) this study effectively treat Botryosphaeria dothidea Botrytis cinerea with higher efficiencies 86.8% 90.1% respectively. provides bright guidance for developing low‐cost, green, eco‐friendly controlling agricultural diseases.

Language: Английский

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