International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(9), P. 4030 - 4030
Published: April 24, 2025
The
global
healthcare
system
is
increasingly
challenged
by
the
rising
prevalence
of
multidrug-resistant
bacteria
and
limited
therapeutic
options
for
related
infections.
Efflux-mediated
antibiotic
resistance
represents
a
significant
obstacle,
primarily
due
to
absence
drugs
specifically
designed
target
bacterial
efflux
pumps.
Recent
research
has
identified
polyphenols,
broad
class
plant-derived
organic
compounds,
as
potential
inhibitors
pump
activity.
This
review
consolidates
data
on
inhibitory
properties
eight
widely
distributed
polyphenols:
curcumin,
quercetin,
luteolin,
tannic
acid,
naringenin,
epigallocatechin-3-gallate,
ellagic
resveratrol.
These
compounds
have
demonstrated
capacity
inhibit
pumps,
either
through
direct
interference
with
protein
function
or
downregulating
expression
genes
encoding
subunits.
Importantly,
several
polyphenols
exhibit
synergistic
interactions
antibiotics,
including
colistin,
ciprofloxacin,
tetracycline.
For
instance,
quercetin
shown
potency
comparable
that
established
such
verapamil
reserpine.
findings
suggest
represent
promising
candidates
development
novel
inhibitors.
However,
further
required
validate
their
efficacy
safety
facilitate
translation
into
clinical
applications
combating
resistance.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 24, 2025
Abstract
Bacterial
plant
diseases,
worsened
by
biofilm‐mediated
resistance,
are
increasingly
threatening
global
food
security.
Numerous
attempts
have
been
made
to
develop
agrochemicals
that
inhibit
biofilms,
however,
their
ineffective
foliar
deposition
and
difficulty
in
removing
mature
biofilms
remain
major
challenges.
Herein,
multifunctional
three‐component
supramolecular
nano‐biscuits
(NI6R@CB[7]@
β
‐CD)
successfully
engineered
via
ordered
self‐assembly
between
two
macrocycles
[cucurbit[7]uril
(CB[7]),
‐cyclodextrin
(
‐CD)]
R
)‐2‐naphthol‐based
bis‐imidazolium
bromide
salt
(NI6R).
This
macrocycles‐involved
bactericidal
material
combines
many
advantages.
1)
Alleviate
the
off‐target
movement
of
droplets
on
hydrophobic
blade
surfaces.
2)
Enhance
biofilm‐disrupting
ability.
At
a
low‐dose
4.44
µg
mL
−1
,
inhibition
rate
biofilm
formation
reached
78.3%.
35.5
potency
remove
77.6%.
3)
Efficiently
hinder
bacterial
reproduction,
swimming,
extracellular
polysaccharide
production,
enzyme
secretion,
virulence
plants.
These
superior
characteristics
undoubtedly
transmitted
vivo
control
effect.
200
this
smart
exhibits
efficiencies
49.6%/65.0%/85.4%
against
three
kinds
diseases
(rice
leaf
blight,
citrus
canker,
kiwifruit
canker),
respectively,
surpassing
commercial
bactericide—thiodiazole‐copper‐20%SC
(33.6%/41.5%/43.2%)
NI6R
(40.3%/51.2%/71.2%).
Furthermore,
NI6R@CB[7]@
‐CD
is
biosafe
non‐target
organisms.
study
instructive
for
constructing
sustainable
crop
protection.
Nano Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 15, 2025
Postcharging
antibacterials
have
shown
good
application
prospects
in
combating
bacterial
infections
through
electrical
interaction.
Herein,
manganese
oxide
nanosheets
situ
grown
on
carbon
fibers
(CM)
are
designed
to
perform
the
integration
of
mechanical
intervention
and
postcharging
therapy
for
efficient
killing.
This
electrode
disrupts
membranes
via
sharp-edged
microstructures.
After
charging
at
a
low
voltage
an
ultrashort
time,
charged
CM
affects
extracellular
electron
transfer
(EET)
bacteria
during
discharge
process
kill
bacteria.
Due
dual-antibacterial
mode,
after
−1
V
(vs
saturated
calomel
electrode,
SCE)
only
50.4
±
3
s,
lethality
rates
against
Escherichia
coli
Staphylococcus
aureus
within
0.5
h
both
exceed
98%.
Our
developed
ultrafast
negatively
exhibits
high
antibacterial
activity
cytotoxicity
fibroblast
cells,
providing
non-antibiotic
approach
combat
infection.
Biomaterials Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Plant-derived
cytoderm
ghost
(PCG)
drug
delivery
systems
leverage
bacterial
responsiveness
to
enable
controlled
release
of
drugs
for
treatment
related
diseases.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(9), P. 4030 - 4030
Published: April 24, 2025
The
global
healthcare
system
is
increasingly
challenged
by
the
rising
prevalence
of
multidrug-resistant
bacteria
and
limited
therapeutic
options
for
related
infections.
Efflux-mediated
antibiotic
resistance
represents
a
significant
obstacle,
primarily
due
to
absence
drugs
specifically
designed
target
bacterial
efflux
pumps.
Recent
research
has
identified
polyphenols,
broad
class
plant-derived
organic
compounds,
as
potential
inhibitors
pump
activity.
This
review
consolidates
data
on
inhibitory
properties
eight
widely
distributed
polyphenols:
curcumin,
quercetin,
luteolin,
tannic
acid,
naringenin,
epigallocatechin-3-gallate,
ellagic
resveratrol.
These
compounds
have
demonstrated
capacity
inhibit
pumps,
either
through
direct
interference
with
protein
function
or
downregulating
expression
genes
encoding
subunits.
Importantly,
several
polyphenols
exhibit
synergistic
interactions
antibiotics,
including
colistin,
ciprofloxacin,
tetracycline.
For
instance,
quercetin
shown
potency
comparable
that
established
such
verapamil
reserpine.
findings
suggest
represent
promising
candidates
development
novel
inhibitors.
However,
further
required
validate
their
efficacy
safety
facilitate
translation
into
clinical
applications
combating
resistance.
