Animals, Journal Year: 2024, Volume and Issue: 14(19), P. 2873 - 2873
Published: Oct. 5, 2024
extract (CME) contains many bioactive compounds, mainly cordycepin (CPN). This study aimed to investigate the possible mechanisms underlying amelioration of LPS-induced acute liver injury in piglets by CME or CPN supplementation using multi-omics analysis. Twenty-four weaned were randomly distributed into 4 groups (
Language: Английский
ACS Nano, Journal Year: 2024, Volume and Issue: 18(21), P. 13885 - 13898
Published: May 17, 2024
Severe acute pancreatitis (SAP), characterized by pancreatic acinar cell death, currently lacks effective targeted therapies. Ellagic acid (EA), rich in pomegranate, shows promising anti-inflammatory and antioxidant effects SAP treatment. However, the roles of other forms EA, such as plant extracellular vesicles (EVs) extracted from Urolithin A (UA), converted EA through gut microbiota metabolism vivo, have not been definitively elucidated. Our research aimed to compare pomegranate-derived EVs (P-EVs) UA treatment screen an formulation explore its mechanisms protecting cells SAP. By comparing protective P-EVs on injured cells, showed superior therapeutic than P-EVs. Subsequently, we further discussed mechanism alleviating inflammation. In vivo animal experiments found that could only improve inflammatory environment tissue peripheral blood circulation mice but also revealed improving might be related mitochondria endoplasmic reticulum (ER) results including transcriptomics transmission electron microscopy. Further regulate ER-mitochondrial calcium channels reduce necroptosis. vitro mouse organoids confirmed inflammation regulating channel necroptosis pathway proteins. This study explored effect alleviate reducing necroptosis, providing insights into pathogenesis potential
Language: Английский
Citations
7
APOPTOSIS, Journal Year: 2024, Volume and Issue: 29(5-6), P. 920 - 933
Published: April 16, 2024
Language: Английский
Citations
5
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)
Published: May 15, 2024
Abstract The modification of cigarette filters with nanozymes has gradually emerged as a promising strategy for reducing the harmful effects smoking by eliminating excessive free radicals and remediating oxidative stress‐induced pulmonary injury. However, currently, available nanozymes‐integrated usually ignore safety concerns fail to address pungent odor smoke, making it challenging develop an individual system high effectiveness while considering these important factors. Herein, novel smoke purifier (CDs/ME@MOF) is developed alternatively introducing carbon dots excellent scavenging activity Menthone masking miscellaneous gas into biocompatible γ‐cyclodextrin‐based metal–organic framework. CDs/ME@MOF can act profitable additive incorporated achieve over 90% efficiency reduce irritation. In mice model, composites demonstrated significant inflammation suppression, antioxidant levels promotion, notable lung tissues protection effect through elimination radicals. This work highlights potential safe, environmentally friendly, multipurpose modifying filter.
Language: Английский
Citations
5
Experimental Cell Research, Journal Year: 2024, Volume and Issue: 435(1), P. 113909 - 113909
Published: Jan. 4, 2024
Language: Английский
Citations
4
Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 2513 - 2530
Published: April 1, 2024
Explore the therapeutic effects and regulatory mechanism of Qingyi Decoction (QYD) on severe acute pancreatitis (SAP) associated lung injury (ALI).
Language: Английский
Citations
4
Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: 73(9), P. 5180 - 5193
Published: Jan. 31, 2025
Overactive immune responses and lung cell damage exacerbate acute injury (ALI). Luteolin, a flavonoid commonly found in traditional herbs, shows potential as an anti-ALI agent pharmacological clinical research, although its biological mechanism is not fully understood. This study aims to investigate whether luteolin can ameliorate ALI through immune-modulatory antinecroptosis mechanisms. We that significantly inhibits the cellular activity of FLT3-dependent monocyte line MOLM-13 BTK-dependent B-cell TMD-8. Through molecular docking HTRF detection, it was confirmed BTK FLT3 enzyme by binding their kinase domains, with IC50 values 0.78 0.35 μM, respectively. In TNF-α-induced epithelial model, reduced increased expression IL1B, IL6, CXCL8 mRNAs blocking necroptosis signal TNF-α/BTK/MLKL. Furthermore, using Balb/c mouse model intratracheal LPS infusion (5 mg/kg), observed improved function pathology, regulated infiltration, death pulmonary tissues inhibiting protein phosphorylation. conclusion, acts natural inhibitor, effectively preventing both vivo vitro immune-modulating properties.
Language: Английский
Citations
0
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 14, 2025
Abstract Acute pancreatitis (AP) is a primary contributor to hospitalization and in‐hospital mortality worldwide. Targeted elimination of mitochondrial reactive oxygen species (mtROS) within pancreatic acinar cells (PACs) represents an ideal strategy for treating AP. However, existing drugs fail overcome the physiological barriers pancreas effectively reach PACs mitochondria due trade‐off between conventional positively charged mitochondrial‐targeting groups their inability penetrate blood‐pancreas barrier (BPB). Here, tungsten‐based heteropolyacid nano‐antioxidant (mTWNDs) introduced, co‐modified with tannic acid (TA) melanin, enabling site‐specific clearance mtROS in PACs, offering highly effective treatment TA exhibits strong affinity proline‐rich type III collagen outer membrane protein TOM20. This unique property allows mTWNDs traverse damaged BPB‐exposing subsequently targeted elimination. In cerulein‐induced AP mice, reversed at 1/50th dose N‐acetylcysteine, suppressing apoptosis inflammation by blocking stimulator interferon genes pathway activation macrophage. study establishes antioxidant nanomedicine treatment.
Language: Английский
Citations
0
Stem Cell Reviews and Reports, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 14, 2025
Several studies have reported the effectiveness of stem cell-derived extracellular vesicles (SC-EVs) in disease treatment. However, efficacy SC-EVs for severe acute pancreatitis (SAP) remains uncertain. This systematic review aimed to analyze and evaluate effect treatment SAP animal models by summarizing data from published studies. We searched Pubmed, Embase, Web Science databases identify preclinical investigating therapeutic on SAP. The primary outcome was histopathological scores pancreatic tissues, including inflammation, edema, necrosis. Other measures included levels amylase, IL-6, IL-10, TNF-α. Eligible were selected based inclusion exclusion criteria. SYRCLE checklist adopted assess quality bias risks Mean differences 95% confidence intervals calculated using inverse variance method with a random effects model. All statistical analyses performed RevMan 5.3 software. A total 8 126 animals included. results meta-analysis revealed that significantly reduced histopathologic (total score: MD = -5.17, CI: -5.79, -4.55; inflammation -1.44, -1.70, -1.19; edema -1.42, -1.75, -1.09; necrosis -1.80, -1.04), inhibited pro-inflammatory factor release (IL-6: SMD -3.20, -4.51, -1.88; TNF-α -5.18, -6.96, -3.40), enhancing anti-inflammatory factors (IL-10 4.15, 2.49, 5.81). Further subgroup displayed obviously attenuated pathologic injury traumatic drug-induced pancreatitis, inhibit secretion model correlated dose injection. alleviation pancreas function reservation. Research into is still its early stage, necessitating further comprehensive investigations future elucidate mechanisms their potential application
Language: Английский
Citations
0
Translational Oncology, Journal Year: 2025, Volume and Issue: 54, P. 102295 - 102295
Published: Feb. 26, 2025
Language: Английский
Citations
0
International Immunopharmacology, Journal Year: 2025, Volume and Issue: 153, P. 114491 - 114491
Published: March 21, 2025
Language: Английский
Citations
0