Journal of Food Composition and Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 107498 - 107498
Published: March 1, 2025
Language: Английский
Advanced Science, Journal Year: 2024, Volume and Issue: unknown
Published: July 3, 2024
Early-stage disease detection, particularly in Point-Of-Care (POC) wearable formats, assumes pivotal role advancing healthcare services and precision-medicine. Public benefits of early detection extend beyond cost-effectively promoting outcomes, to also include reducing the risk comorbid diseases. Technological advancements enabling POC biomarker recognition empower discovery new markers for various health conditions. Integration wearables with intelligent frameworks represents ground-breaking innovations automation operations, conducting advanced large-scale data analysis, generating predictive models, facilitating remote guided clinical decision-making. These substantially alleviate socioeconomic burdens, creating a paradigm shift diagnostics, revolutionizing medical assessments technology development. This review explores critical topics recent progress development 1) systems solutions physiological monitoring, as well 2) discussing current trends adoption smart technologies within settings developing biological assays, ultimately 3) exploring utilities platforms discovery. Additionally, translation from research labs broader applications. It addresses associated risks, biases, challenges widespread Artificial Intelligence (AI) integration diagnostics systems, while systematically outlining potential prospects, challenges, opportunities.
Language: Английский
Citations
24
Trends in Food Science & Technology, Journal Year: 2023, Volume and Issue: 142, P. 104230 - 104230
Published: Nov. 5, 2023
Language: Английский
Citations
32
Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 149, P. 104564 - 104564
Published: May 27, 2024
Language: Английский
Citations
13
ACS Nano, Journal Year: 2024, Volume and Issue: 18(11), P. 8270 - 8282
Published: March 7, 2024
Respiratory infections and food contaminants pose severe challenges to global health the economy. A rapid on-site platform for simultaneous detection of multiple pathogens is crucial accurate diagnosis, appropriate treatment, a reduced healthcare burden. Herein, we present spheres-on-sphere (SOS) multiplexed using portable Coulter counter, which employs millimeter- micron-sized spheres coupled with antibodies as multitarget probes. The assay allows quantitative analytes within 20 min by simple mixing, enabling detection. shows high accuracy in identifying three respiratory viruses (SARS-CoV-2, influenza virus, parainfluenza virus) from throat swab samples, LOD 50.7, 32.4, 49.1 pg/mL. It also demonstrates excellent performance quantifying mycotoxins (aflatoxin B1, deoxynivalenol, ochratoxin A) samples. SOS offers approach sensitivity specificity applications resource-limited settings.
Language: Английский
Citations
10
Advanced Science, Journal Year: 2024, Volume and Issue: 12(2)
Published: Nov. 22, 2024
Abstract Bacterial infection is a crucial factor resulting in public health issues worldwide, often triggering epidemics and even fatalities. The accurate, rapid, convenient detection of viable bacteria an effective method for reducing infections illness outbreaks. Here, unsupervised learning–assisted surface acoustic wave–interdigital transducer‐driven nano‐lens holography biosensing platform developed the ultrasensitive amplification‐free bacteria. monitoring device integrated with effect can achieve holographic imaging polystyrene microsphere probes ultra‐wide field view (∽28.28 mm 2 ), sensitivity limit as low 99 nm. A lightweight learning hologram processing algorithm considerably reduces training time computing hardware requirements, without requiring datasets manual labels. By combining phage–mediated bacterial DNA extraction enhanced CRISPR–Cas12a systems, this strategy successfully achieves Salmonella various real samples, demonstrating accuracy validated qPCR benchmark method. This approach has cost (∽$500) rapid (∽1 h) highly sensitive (∽38 CFU mL −1 allowing emerging powerful tool food safety inspection clinical diagnosis.
Language: Английский
Citations
9
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 3, 2025
Development of a multiplexed and sensitive biosensing platform is priority for public health security. We report micropore resistance counting based on polystyrene microsphere size-based encoding Clostridium butyricum Argonaute (CbAgo) decoding ultrasensitive detection. Initially, we constructed target DNA-modified coding system counting. Subsequently, the precise recognition cleavage capabilities guide DNA-activated CbAgo protein enable encoded system. Changes in concentration microspheres are presented as signal readout. The demonstrated excellent performance detection three mycotoxins (with sensitivity range over 4 orders magnitude reaching pg/mL level) two inflammatory markers at pg/mL. Combining enzyme by with counting, developed highly tool wide-ranging potential applications such clinical diagnosis, food safety inspection, environmental monitoring.
Language: Английский
Citations
1
Deleted Journal, Journal Year: 2024, Volume and Issue: 6(9)
Published: Aug. 23, 2024
Abstract The potential threat posed by disease outbreaks to diagnostic instruments demands the development of more effective biosensor technologies counteract risks. Diseases like SARS-CoV-2, Ebola, malaria, cholera, and many have demonstrated beyond limits health care that new advancements are required for early detection diagnosis. rising number diseases has led an increasing demand biosensors quicker utilize in healthcare settings. A incorporated with microfluidic chips offers improved compared traditional or classical biosensors. Microfluidic improve performance allowing automation, mixing, separation, throughput processing, transport analytes desired reactors. a chip sensitivity, easy operation can use small volumes samples process results. effectiveness depends also on materials used its fabrication there which reviewed this work. This paper reviews advantages enhance biosensors, fabricate chips, electrodes into time shortening processing at point service. work not previously addressed other including, integration cell-imprinted polymers sensors delved future outlook.
Language: Английский
Citations
7
Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(18), P. 7145 - 7154
Published: April 24, 2024
Immunoassays serve as powerful diagnostic tools for early disease screening, process monitoring, and precision treatment. However, the current methods are limited by high costs, prolonged processing times (>2 h), operational complexities that hinder their widespread application in point-of-care testing. Here, we propose a novel centrifugo-pneumatic reciprocating flowing coupled with spatial confinement strategy, termed PRCM, ultrafast multiplexed immunoassay of pathogens on centrifugal microfluidic platform. Each chip consists four replicated units; each unit allows simultaneous detection three targets, thereby facilitating high-throughput parallel analysis multiple targets. The PRCM platform enables sequential execution critical steps such solution mixing, reaction, drainage coordinating inherent parameters, including motor rotation speed, direction, acceleration/deceleration. By integrating centrifugal-mediated pneumatic flow strategies, significantly reduce duration immune binding from 30 to 5 min, enabling completion entire testing within 20 min. As proof concept, conducted comparative test on- off-the-microfluidics using 12 negative positive clinical samples. outcomes yielded 100% accuracy detecting presence or absence SARS-CoV-2 virus, thus highlighting potential our system immunoassays.
Language: Английский
Citations
6
TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 181, P. 118004 - 118004
Published: Oct. 9, 2024
Language: Английский
Citations
6
Food Chemistry, Journal Year: 2023, Volume and Issue: 437, P. 137740 - 137740
Published: Oct. 14, 2023
Language: Английский
Citations
14