Aging Research,
Journal Year:
2023,
Volume and Issue:
1(2), P. 9340020 - 9340020
Published: Dec. 1, 2023
Alzheimer's
disease
(AD),
a
prevalent
form
of
dementia
in
the
elderly,
is
characterized
by
marked
neurodegeneration
and
cognitive
decline.
Central
to
its
pathology
are
Amyloid-beta
plaques,
neurofibrillary
tangles,
neuroinflammation.
This
review
delves
into
pivotal
role
microglia,
primary
immune
cells
central
nervous
system,
AD's
progression.
We
highlight
recent
discoveries
revealing
how
abnormal
microglial
activity,
influenced
mitochondrial
dysfunction,
contributes
AD
development.
Special
attention
given
bidirectional
relationship
between
microglia
mitochondria,
including
impact
metabolic
disturbances
energy
dysregulation
on
function.
Further,
we
explore
mechanisms
underlying
activation
consequences
neuronal
health,
interplay
inflammatory
pathways
dynamics.
Our
comprehensive
analysis
underscores
significance
homeostasis
functionality
implications
for
progression,
offering
insights
potential
therapeutic
avenues
targeting
mitochondria
AD.
Immunity Inflammation and Disease,
Journal Year:
2024,
Volume and Issue:
12(11)
Published: Nov. 1, 2024
ABSTRACT
Background
The
effectiveness
of
ultrasound
stimulation
in
treating
Alzheimer's
disease
(AD)
has
been
reported
previous
studies,
but
the
underlying
mechanisms
remain
unclear.
This
study
investigated
effects
on
proportion
and
function
microglia
different
phenotypes,
as
well
levels
inflammatory
factors.
Additionally,
it
revealed
alterations
proteomic
molecules
mouse
hippocampus
following
treatment,
aiming
to
uncover
potential
new
molecular
mechanisms.
Methods
Ultrasound
was
used
stimulate
for
30
min
per
day
5
days
stimulation‐treated
group.
Amyloid
plaque
deposition
measured
using
immunofluorescence
staining.
M1
M2
type
were
labeled
immunofluorescent
double
staining,
ratio
calculated.
Aβ42,
IL‐10,
TNF‐α
determined
ELISA
kits.
quantitative
proteomics
method
employed
explore
changes
hippocampal
proteins.
Results
treatment
reduced
average
fluorescence
intensity
amyloid
plaques
concentration
Aβ42.
Compared
AD
group,
resulted
a
14%
reduction
12%
increase
microglia.
anti‐inflammatory
factor
IL‐10
significantly
increased
Proteomics
analysis
753
differentially
expressed
proteins
between
groups,
with
most
being
enriched
oxidative
phosphorylation
pathway
mitochondria.
activity
cytochrome
c
oxidase,
involved
phosphorylation,
after
treatment.
Conclusions
affects
microglial
polarization,
reduces
load,
enhances
factors
APP/PS1
mice.
reveals
mechanism
behind
stimulation‐induced
modulation
polarization
may
be
related
mitochondrial
phosphorylation.
Aging Research,
Journal Year:
2023,
Volume and Issue:
1(2), P. 9340020 - 9340020
Published: Dec. 1, 2023
Alzheimer's
disease
(AD),
a
prevalent
form
of
dementia
in
the
elderly,
is
characterized
by
marked
neurodegeneration
and
cognitive
decline.
Central
to
its
pathology
are
Amyloid-beta
plaques,
neurofibrillary
tangles,
neuroinflammation.
This
review
delves
into
pivotal
role
microglia,
primary
immune
cells
central
nervous
system,
AD's
progression.
We
highlight
recent
discoveries
revealing
how
abnormal
microglial
activity,
influenced
mitochondrial
dysfunction,
contributes
AD
development.
Special
attention
given
bidirectional
relationship
between
microglia
mitochondria,
including
impact
metabolic
disturbances
energy
dysregulation
on
function.
Further,
we
explore
mechanisms
underlying
activation
consequences
neuronal
health,
interplay
inflammatory
pathways
dynamics.
Our
comprehensive
analysis
underscores
significance
homeostasis
functionality
implications
for
progression,
offering
insights
potential
therapeutic
avenues
targeting
mitochondria
AD.
