Multienzymatic Orthogonal Activation of DNA Codec Enables Tumor-Specific Imaging of Base Excision Repair Activity DOI

Weijia Zeng,

Zhaopeng Chen, Yan‐Mei Lei

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(40), P. 15915 - 15923

Published: Sept. 26, 2024

Accurate monitoring of base excision repair (BER) activity in cancer cells is critical for advancing the comprehension DNA processes, gaining insights into development, and guiding treatment strategies. However, current assay techniques assessing BER face challenges due to heterogeneous origins diversity enzymes. In this work, we present a hi

Language: Английский

Ferroptosis: emerging roles in lung cancer and potential implications in biological compounds DOI Creative Commons

Qiuran Liang,

Yuehui Wang,

Yili Li

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 9, 2024

Lung cancer has high metastasis and drug resistance. The prognosis of lung patients is poor the patients’ survival chances are easily neglected. Ferroptosis a programmed cell death proposed in 2012, which differs from apoptosis, necrosis autophagy. novel type regulated driven by iron-dependent lipid peroxidation subsequent plasma membrane ruptures. It broad prospects field tumor disease treatment. At present, multiple studies have shown that biological compounds can induce ferroptosis cells, exhibits significant anti-cancer effects, they advantages safety, minimal side less possibility to In this review, we summarize used for treatment focusing on its mechanism. addition, systematically review current research status combining nanotechnology with treatment, shed new light targeting pathways applying compounds-based therapies.

Language: Английский

Citations

3
A Minimalist Iron Oxide Nanoprobe for the High‐Resolution Depiction of Stroke by Susceptibility‐Weighted Imaging DOI
Bing Han, Yujie Zhao, Li Ma

et al.

Small, Journal Year: 2024, Volume and Issue: 20(44)

Published: July 4, 2024

The precise mapping of collateral circulation and ischemic penumbra is crucial for diagnosing treating acute stroke (AIS). Unfortunately, there exists a significant shortage high-sensitivity high-resolution in vivo imaging techniques to fulfill this requirement. Herein, contrast enhanced susceptibility-weighted (CE-SWI) using the minimalist dextran-modified Fe

Language: Английский

Citations

3
Recent advances of nanomaterials in imaging liver fibrosis DOI Creative Commons
Jin Cui, Shuxuan Zhang,

Xueli Xu

et al.

BMEMat, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Abstract Liver fibrosis is a pathological process resulting from prolonged exposure to various injury factors. It characterized by the abnormal proliferation and activation of hepatic stellate cells excessive deposition extracellular matrix. If left untreated, it can progress cirrhosis, liver failure, even cancer. There currently no efficient accurate clinical diagnostic method for early fibrosis. Therefore, there an urgent need address challenge staging diagnosis in practice. Recently, nanomaterials have demonstrated significant potential enhancing Nanomaterials possess ability precisely identify target microenvironment associated with By their enrichment area, improve imaging contrast lesions liver, thereby enabling Accordingly, this review delves into latest research advancements concerning diagnosis.

Language: Английский

Citations

3
Nanointegrative In Situ Reprogramming of Tumor-Intrinsic Lipid Droplet Biogenesis for Low-Dose Radiation-Activated Ferroptosis Immunotherapy DOI
Qiqi Zhang, Xuan Wang, Yuanyuan Zhao

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(24), P. 25419 - 25438

Published: Dec. 6, 2023

Low-dose radiotherapy (LDR) has shown significant implications for inflaming the immunosuppressive tumor microenvironment (TME). Surprisingly, we identify that FABP-dependent lipid droplet biogenesis in cells is a key determinant of LDR-evoked cytotoxic and immunostimulatory effects developed nanointegrated strategy to promote antitumor efficacy LDR through cooperative ferroptosis immunotherapy. Specifically, TCPP-TK-PEG-PAMAM-FA, nanoscale multicomponent functional polymer with self-assembly capability, was synthesized cooperatively entrapping hafnium ions (Hf4+) HIF-1α-inhibiting siRNAs (siHIF-1α). The TCPP@Hf-TK-PEG-PAMAM-FA@siHIF-1α nanoassemblies are specifically taken by folate receptor-overexpressing activated elevated cellular ROS stress. siHIF-1α could readily inhibit FABP3/7 expression via HIF-1α-FABP3/7 signaling abolish enhancing peroxidation susceptibility membrane lipids, which synergizes stress context Hf4+-enhanced radiation exposure evokes pronounced ferroptotic damage vital structures. Interestingly, TCPP@Hf-TK-PEG-PAMAM-FA@siHIF-1α-enhanced biomembrane also facilitates tumor-associated antigens (TAAs) post-LDR immunotherapeutic effects, leading robust regression vivo. This study offers nanointegrative approach boost utilization tumor-intrinsic metabolism.

Language: Английский

Citations

7
Multienzymatic Orthogonal Activation of DNA Codec Enables Tumor-Specific Imaging of Base Excision Repair Activity DOI

Weijia Zeng,

Zhaopeng Chen, Yan‐Mei Lei

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(40), P. 15915 - 15923

Published: Sept. 26, 2024

Accurate monitoring of base excision repair (BER) activity in cancer cells is critical for advancing the comprehension DNA processes, gaining insights into development, and guiding treatment strategies. However, current assay techniques assessing BER face challenges due to heterogeneous origins diversity enzymes. In this work, we present a hi

Language: Английский

Citations

2