Oral
ulcer
wounds
are
difficult
to
heal
due
bacterial
infections,
persistent
inflammatory
responses,
and
excessive
reactive
oxygen
species
(ROS).
Therefore,
the
elimination
of
bacteria,
removal
ROS,
reduction
inflammation
prerequisites
for
treatment
mouth
wounds.
In
this
study,
oligomeric
proanthocyanidins
(OPC)
3-(aminomethyl)phenylboronic
acid-modified
hyaluronic
acid
(HP)
were
used
form
polymer
gels
through
dynamic
covalent
borate
bonds.
Minocycline
hydrochloride
(MH)
was
then
loaded
into
gel,
a
multifunctional
MH/OPC-HP
microneedles
(MNs)
with
ROS-responsive
properties
prepared
using
vacuum
method.
The
MNs
can
rapidly
release
MH
in
diffusive
manner
sustainably
OPC
response
ROS.
gel-based
extended
retention
oral
ulcers,
leading
prolonged
ROS
scavenging
effects.
Cytocompatibility
hemocompatibility
tests
showed
that
had
good
biocompatibility.
Antibacterial
experiments
demonstrated
exhibited
excellent
antibacterial
vitro
indicated
could
effectively
clear
reduce
oxidative
stress
damage,
inhibit
M1-type
macrophage
polarization,
induce
M2-type
polarization.
Furthermore,
vivo
revealed
pro-inflammatory
cytokines,
promote
neovascularization,
accelerate
epithelial
healing
significantly
rat
model
wound
infection.
summary,
hold
promise
as
therapeutic
strategy
enhancing
iScience,
Journal Year:
2025,
Volume and Issue:
28(2), P. 111763 - 111763
Published: Jan. 7, 2025
Recent
years
have
witnessed
tremendous
advances
in
wearable
sensors,
which
play
an
essential
role
personalized
healthcare
for
their
ability
real-time
sensing
and
detection
of
human
health
information.
Nanozymes,
capable
mimicking
the
functions
natural
enzymes
addressing
limitations,
possess
unique
advantages
such
as
structural
stability,
low
cost,
ease
mass
production,
making
them
particularly
beneficial
constructing
recognition
units
biosensors.
In
this
review,
we
aim
to
delineate
latest
advancements
nanozymes
development
biosensors,
focusing
on
key
developments
nanozyme
immobilization
strategies,
technologies,
biomedical
applications.
The
review
also
highlights
current
challenges
future
perspectives.
Ultimately,
it
aims
provide
insights
research
endeavors
rapidly
evolving
area.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
31, P. 101467 - 101467
Published: Jan. 8, 2025
Defective
diabetic
wound
healing
is
a
major
clinical
challenge,
where
hyperglycemia
at
the
site
induces
excessive
reactive
oxygen
species
(ROS)
which
activate
MAPK
pathway
(particularly
p38
MAPK),
resulting
in
sustained
release
of
inflammatory
factors
and
cellular
damage/apoptosis.
Polyphenols
are
efficient
ROS
scavengers
reduce
level
inflammation
promote
healing,
but
low
bioavailability
limits
their
biomedical
application.
This
study
developed
simple
highly
method
for
preparing
proanthocyanidin
(PC)
capsules
through
hydrogen
bonding
hydrophobic
interactions
among
PC
molecules.
can
continuously
scavenge
free
radicals
proanthocyanidins,
significantly
enhancing
bioavailability.
A
single
dose
accelerates
mice
by
regulating
signaling
cascade,
reducing
mediator
concentration,
inhibiting
cell
apoptosis,
remodeling
microenvironment.
research
makes
an
important
contribution
to
field
polyphenol
reveals
potential
modulating
treating
other
oxidative
stress-related
diseases.
Oral
ulcer
wounds
are
difficult
to
heal
due
bacterial
infections,
persistent
inflammatory
responses,
and
excessive
reactive
oxygen
species
(ROS).
Therefore,
the
elimination
of
bacteria,
removal
ROS,
reduction
inflammation
prerequisites
for
treatment
mouth
wounds.
In
this
study,
oligomeric
proanthocyanidins
(OPC)
3-(aminomethyl)phenylboronic
acid-modified
hyaluronic
acid
(HP)
were
used
form
polymer
gels
through
dynamic
covalent
borate
bonds.
Minocycline
hydrochloride
(MH)
was
then
loaded
into
gel,
a
multifunctional
MH/OPC-HP
microneedles
(MNs)
with
ROS-responsive
properties
prepared
using
vacuum
method.
The
MNs
can
rapidly
release
MH
in
diffusive
manner
sustainably
OPC
response
ROS.
gel-based
extended
retention
oral
ulcers,
leading
prolonged
ROS
scavenging
effects.
Cytocompatibility
hemocompatibility
tests
showed
that
had
good
biocompatibility.
Antibacterial
experiments
demonstrated
exhibited
excellent
antibacterial
vitro
indicated
could
effectively
clear
reduce
oxidative
stress
damage,
inhibit
M1-type
macrophage
polarization,
induce
M2-type
polarization.
Furthermore,
vivo
revealed
pro-inflammatory
cytokines,
promote
neovascularization,
accelerate
epithelial
healing
significantly
rat
model
wound
infection.
summary,
hold
promise
as
therapeutic
strategy
enhancing
