Selenocysteine-Activatable Near-Infrared Fluorescent Probe for Screening of Anti-inflammatory Components in Herbs DOI
Hao Liu,

Wangning Zhang,

Sisi Wang

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 4, 2025

Inflammation, a central process in numerous diseases, plays crucial role hepatic disorders, arthritis, cardiac conditions, and neurodegenerative ailments. Given the lack of effective anti-inflammatory drugs, it is imperative to assess inflammation severity explore novel therapeutics. Selenocysteine (Sec), key mediator selenium's biological function, closely involved responses. We have synthesized near-infrared fluorescent probe, Sec-BDP, which can image Sec dynamics vivo with high selectivity sensitivity. Sec-BDP detects at concentrations as low 0.085 μM. Utilizing this we visualized levels cell, zebrafish, mouse models, enabling clear assessment severity. To screen for drug candidates, was integrated ultrahigh performance liquid chromatography quadrupole time-of-flight mass spectrometry identify potent compounds Astragalus membranaceus, such 5-O-methylvisammioside. Imaging provides insights into Sec-related diseases aids discovering new treatments. This probe advances selenium biology promises more targeted therapeutic strategies.

Language: Английский

Selenoprotein‐Regulated Hydrogel for Ultrasound‐Controlled Microenvironment Remodeling to Promote Bone Defect Repair DOI
Renhao Xu,

Yuanyuan You,

Wenyi Zheng

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(12)

Published: Jan. 14, 2024

Abstract Abnormal levels of reactive oxygen species (ROS) and the hypoxic microenvironment within bone defects are important factors that impede repair processes. Herein, an innovative ultrasound‐modulatable hydrogel platform with selenoprotein‐mediated antioxidant effects to promote injury is presented. This encapsulates oxygen‐enriched selene‐incorporated thin‐shell silicon methacrylate gelatin (O 2 ‐PSSG). The resultant construct orchestrates modulation bone‐defect microenvironment, thereby expediting course regeneration. Ultrasound (US) used regulate pore size release selenium‐containing nanoparticles in situ synthesis efficient intracellular selenoproteins hydrogen peroxide consumption. As expected, O ‐PSSG rapidly releases selenocystine ([Sec] ) under US control scavenge maintain homeostasis marrow mesenchymal stem cells (BMSCs). Over time, action system by selenoprotein increases activation Wnt/β‐catenin pathways promotes differentiation BMSCs. Consequently, potentiates proficiency BMSCs both vitro vivo, alleviates environments, osteogenic differentiation, expedites cranial rat models. In summary, this study suggests designed constructed US‐responsive a promising prospective strategy for addressing fostering

Language: Английский

Citations

19
Size effect-based improved antioxidant activity of selenium nanoparticles regulating Anti-PI3K-mTOR and Ras-MEK pathways for treating spinal cord injury to avoid hormone shock-induced immunosuppression DOI Creative Commons
Peixin Liu, Xiaodong Liu,

Zihao Wu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 16, 2025

Language: Английский

Citations

2
Unveiling Green Synthesis and Biomedical Theranostic paradigms of Selenium Nanoparticles (SeNPs) - A state-of-the-art comprehensive update DOI Creative Commons
Sagnik Nag,

Shinjini Kar,

Shatakshi Mishra

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 662, P. 124535 - 124535

Published: Aug. 1, 2024

The advancements in nanotechnology, pharmaceutical sciences, and healthcare are propelling the field of theranostics, which combines therapy diagnostics, to new heights; emphasizing emergence selenium nanoparticles (SeNPs) as versatile theranostic agents. This comprehensive update offers a holistic perspective on recent developments synthesis applications SeNPs, underscoring their growing importance nanotechnology healthcare. SeNPs have shown significant potential multiple domains, including antioxidant, anti-inflammatory, anticancer, antimicrobial, antidiabetic, wound healing, cytoprotective therapies. review highlights adaptability biocompatibility crucial for advanced disease detection, monitoring, personalized treatment. Special emphasis is placed green techniques, eco-friendly cost-effective benefits biosensing, imaging therapeutic applications. Additionally, appraisal scrutinizes progressive trends smart stimuli-responsive conferring role innovative solutions management diagnostics. Despite promising prophylactic potential, also present several challenges, particularly regarding toxicity concerns. These challenges implications clinical translation thoroughly explored, providing balanced view current state prospects

Language: Английский

Citations

15
Synergistic anti-oxidative/anti-inflammatory treatment for acute lung injury with selenium based chlorogenic acid nanoparticles through modulating Mapk8ip1/MAPK and Itga2b/PI3k-AKT axis DOI Creative Commons

Huizhen Xing,

Xueli Bai,

Xiaoying Pei

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 23, 2025

Language: Английский

Citations

1
Synthesis and Application of Selenium Nanoparticles for the Modulation of Inflammatory Diseases DOI Creative Commons
Xueli Bai, Tianfei Zhou, Xiaowen Wu

et al.

Nano Biomedicine and Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

1
Cascade Targeting Selenium Nanoparticles-Loaded Hydrogel Microspheres for Multifaceted Antioxidant Defense in Osteoarthritis DOI
Jiacheng Liu, Junyan Liu, Senrui Liu

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123195 - 123195

Published: Feb. 15, 2025

Language: Английский

Citations

1
Selenium promotes immunogenic radiotherapy against cervical cancer metastasis through evoking P53 activation DOI
Yanchao Xu, Haoqiang Lai, Shuya Pan

et al.

Biomaterials, Journal Year: 2023, Volume and Issue: 305, P. 122452 - 122452

Published: Dec. 24, 2023

Language: Английский

Citations

19
Injectable, anti-collapse, adhesive, plastic and bioactive bone graft substitute promotes bone regeneration by moderating oxidative stress in osteoporotic bone defect DOI Creative Commons
Lei Huang, Shihao Zhang, Mengxuan Bian

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 180, P. 82 - 103

Published: April 15, 2024

The treatment of osteoporotic bone defect remains a big clinical challenge because osteoporosis (OP) is associated with oxidative stress and high levels reactive oxygen species (ROS), condition detrimental for formation. Anti-oxidative nanomaterials such as selenium nanoparticles (SeNPs) have positive effect on osteogenesis owing to their pleiotropic pharmacological activity which can exert anti-oxidative functions prevent loss facilitate regeneration in OP. In the current study strategy one-pot method by introducing Poly (lactic acid-carbonate) (PDT) β-Tricalcium Phosphate (β-TCP) SeNPs, developed prepare an injectable, anti-collapse, shape-adaptive adhesive graft substitute material (PDT-TCP-SE). PDT-TCP-SE exhibits sufficient adhesion biological microenvironments osteoinductive activity, angiogenic anti-inflammatory well vitro vivo. Moreover, protect BMSCs from erastin-induced ferroptosis through Sirt1/Nrf2/GPX4 antioxidant pathway, which, together, demonstrated emerging biomaterial potential application future defects. Injectable, adhesive, plastic bioactive was successfully synthesized. Incorporation SeNPs PDT into β-TCP regenerated new in-situ moderating defects area. reduced ROS microenvironment. could also moderate inhibit via pathway vitro. alleviate inflammatory environment promote This has advantages simple synthesis, biocompatibility, regulation level, value tissue engineering.

Language: Английский

Citations

8
Translational selenium nanoparticles boost GPx1 activation to reverse HAdV-14 virus-induced oxidative damage DOI Creative Commons
Yinghua Li, Ting Liu,

Ruilin Zheng

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 38, P. 276 - 291

Published: May 7, 2024

Human adenovirus (HAdV) can cause severe respiratory infections in immunocompromised patients, but its clinical treatment is seriously limited by side effects of drugs such as poor efficacy, low bioavailability and nephrotoxicity. Trace element selenium (Se) has been found will affect the disease progression pneumonia, antivirus efficacy could be improved speciation optimization. Therefore, herein we performed anti-HAdV different Se that lentinan (LNT)-decorated nanoparticles (SeNPs) exhibited cytotoxicity excellent antiviral activity. Furthermore, SeNPs@LNT reduced HAdV infection-induced mitochondrial damage excessive production reactive oxygen species (ROS). It was also involved repair host cell DNA inhibition viral replication. inhibited HAdV-induced apoptosis mainly modulating p53/Bcl-2 signaling pathway. In vivo, replenished targeting infected site through circulatory system synthesis Glutathione peroxidase 1 (GPx1). More importantly, GPx1 played an antioxidant immunomodulatory role alleviating inflammatory cytokine storm pneumonia Se-deficient mice. Collectively, this study provides a with activity, demonstrate promising pharmaceutical candidate for HAdV.

Language: Английский

Citations

8
Selenium Attenuates Radiation Colitis by Regulating cGAS‐STING Signaling DOI Creative Commons
Xuefeng Qian, Haoqiang Lai,

Haimei Zhang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 30, 2024

Abstract Radiation colitis is one of the most common complications in patients undergoing pelvic radiotherapy and there no effective treatment clinic. Therefore, searching for agents radiation urgently needed. Herein, it found that essential element selenium (Se) protective against through inhibiting X‐ray‐induced apoptosis, cell cycle arrest, inflammation with involvement balancing generation reactive oxygen species after irradiation. Mechanistically, Se, especially nanoparticles (SeNPs), induced selenoprotein expression then functioned to effectively restrain DNA damage response, which reduced intestinal injury. Additionally, SeNPs also restrained cyclic GMP‐AMP synthas (cGAS)‐ stimulator interferon genes (STING)‐TBK1‐IRF3 signaling pathway cascade, thereby blocking transcription inflammatory cytokine gene, IL‐6 TNF‐α, thus alleviating inflammation. Moreover, inducing expression, such as GPX4, vivo can regulate microenvironment immunity gut microbiota attenuate radiation‐induced by oxidative stress maintaining homeostasis. Together, these results unravel a previously unidentified modulation role but suppressing cGAS‐STING‐TBK1‐IRF3 cascade.

Language: Английский

Citations

8